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Table 3 Pharmacokinetic parameters after 3-h extended infusion (EI) of 1000 mg meropenem 8 h for first and third days

From: Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria

Pharmacokinetic parametersDay 1 (first dose) (n = 24a)Day 3 (seventh dose) (n = 23b)Changec from day 1 to day 3 (%)Pd
Cmax (μg/mL)15.36 ± 1.1114.14 ± 2.02− 7.1NS
AUC (μg h/mL)57.92 ± 5.9843.82 ± 7.33− 24.3NS
T1/2 (h)1.31 ± 0.240.6 ± 0.23− 54.20.04
Ke (1/h)0.53 ± 0.101.15 ± 0.44+ 116.1NS
Vd (L)32.61 ± 4.319.83 ± 6.13− 39.2NS
Cl (L/h)17.26 ± 1.7822.86 ± 3.82+ 32.4NS
  1. All values shown as mean ± SE
  2. Cmax maximum plasma concentration, NS not significant, AUC area under concentration–time curve, T1/2 half-life, Ke elimination rate constant, Vd apparent volume of distribution, Cl total body clearance
  3. P < 0.05 statistically significant
  4. aOne patient was withdrawn from the analysis as the blood samples were hemolyzed
  5. bOne patient expired before collection of day three samples
  6. c(+) indicates increase and (−) indicates decrease from day 1 to day 3
  7. dPaired data of 23 patients between day 1 and day 3 compared using paired t-test