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Table 3 Pharmacokinetic parameters after 3-h extended infusion (EI) of 1000 mg meropenem 8 h for first and third days

From: Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria

Pharmacokinetic parameters Day 1 (first dose) (n = 24a) Day 3 (seventh dose) (n = 23b) Changec from day 1 to day 3 (%) Pd
Cmax (μg/mL) 15.36 ± 1.11 14.14 ± 2.02 − 7.1 NS
AUC (μg h/mL) 57.92 ± 5.98 43.82 ± 7.33 − 24.3 NS
T1/2 (h) 1.31 ± 0.24 0.6 ± 0.23 − 54.2 0.04
Ke (1/h) 0.53 ± 0.10 1.15 ± 0.44 + 116.1 NS
Vd (L) 32.61 ± 4.3 19.83 ± 6.13 − 39.2 NS
Cl (L/h) 17.26 ± 1.78 22.86 ± 3.82 + 32.4 NS
  1. All values shown as mean ± SE
  2. Cmax maximum plasma concentration, NS not significant, AUC area under concentration–time curve, T1/2 half-life, Ke elimination rate constant, Vd apparent volume of distribution, Cl total body clearance
  3. P < 0.05 statistically significant
  4. aOne patient was withdrawn from the analysis as the blood samples were hemolyzed
  5. bOne patient expired before collection of day three samples
  6. c(+) indicates increase and (−) indicates decrease from day 1 to day 3
  7. dPaired data of 23 patients between day 1 and day 3 compared using paired t-test