Table 2 Hemodynamics, respiratory mechanics, blood gases analysis, \(V_{{{\text{CO}}_{2} }}\), VD/VT and microcirculatory parameters at baseline and 24 h after
Baseline | 24 h | p | |
|---|---|---|---|
Hemodynamics | |||
HR, bpm | 104 (94–121) | 100 (89–115) | 0.43 |
MAP, mmHg | 74 (69–87) | 75 (67–92) | 0.35 |
CVP, mmHg, n | 12 (8–14) | 12 (7–14) | 0.96 |
PAOP, mmHg, n | 14 (12–16), 22 | 19 (16–22), 24 | 0.03 |
PAPm, mmHg, n | 36 (42–46), 22 | 30 (26–41), 24 | 0.13 |
PVR, dyn.s/cm5, n | 298 (250–440), 22 | 299 (211–360), 24 | 0.86 |
Cardiac index, (l/min/m2), n | 4.2 (3.4–4.5), 22 | 3.9 (3.5–4.4), 24 | 0.30 |
Norepinephrine, (ugr/kg/min), n | 0.10 (0.05–0.27), 18 | 0.05 (0.03–0.34), 18 | 0.09 |
Respiratory mechanics and blood gases | |||
VT, ml | 369 (325–415) | 363 (312–404) | 0.56 |
VT, ml/kg | 6.5 (6.1–6.9) | 6.6 (6.4–6.9) | 0.56 |
RR | 24 (20–26) | 25 (22–27) | 0.17 |
PEEP | 12 (10–15) | 12 (10–14) | 0.07 |
PPeak | 30 (27–33) | 29 (26–34) | 0.57 |
Pmaw | 19 (14–21) | 18 (15–20) | 0.36 |
VT/CRS | 17 (14–19) | 16 (14–18) | 0.42 |
pH | 7.28 (7.21–7.32) | 7.35 (7.26–7.39) | < 0.001 |
PaO2, mmHg | 79.1 (69.7–95.5) | 86.6 (72.6–109.2) | 0.06 |
PaCO2, mmHg | 46.6 (39.9–56.3) | 42.3 (34.6–47.6) | 0.003 |
HCO3, mmol/L | 20.9 (19.1–24.2) | 20.7 (17.8–26.5) | 0.78 |
BE, mmol/L | − 6.4 (− 8.8 to − 2.3) | − 5.9 (− 8.4 to − 0.05) | 0.03 |
PaO2/FiO2 | 119 (93–148) | 173 (124–222) | < 0.001 |
PvO2, mmHg | 48.7 (42.3–54.1) | 40.8 (36.9–47.6) | 0.004 |
PvCO2, mmHg | 48.2 (41.6–59.3) | 44.6 (36.1–53.6) | 0.003 |
ScvO2, % | 78.0 (70.9–80.9) | 75.2 (62.3–81.7) | 0.17 |
Capnography/expired CO2 | |||
\(P_{{{\text{ECO}}_{2} }}\), mmHg (BTPS) | 21.2 (18.4–24.6) | 19.3 (14.8–21.6) | 0.01 |
\(F_{{{\text{ECO}}_{2} }}\) | 0.034 (0.029–0.039) | 0.030 (0.023–0.034) | 0.01 |
\(V_{{{\text{CO}}_{2} }}\), ml/min (STPD) | 320 (250–405) | 259 (201–380) | 0.28 |
VTE, ml | 372 (325–415) | 302 (240–440) | 0.39 |
VD/VT | 54 (45–61) | 51 (47–61) | 0.44 |
Microcirculatory blood flow parameters | |||
PPV, % | 69.6 (57.8–79.2) | 75.7 (62.8–81.5) | 0.01 |
LVP, % | 90.9 (82.3–96.5) | 90.3 (85.3–96.8) | 0.52 |
FCD, n vessels/mm2 | 6.6 (5.1–7.5) | 6.9 (5.5–8.2) | 0.03 |
TCD, n vessels/mm2 | 11.6 (10.8–12.6) | 12.3 (11.0–13.3) | 0.08 |
MFI | 2.35 (2.08–2.50) | 2.35 (2.20–2.60) | 0.06 |
Heterogeneity index | 0.38 (0.27–0.65) | 0.28 (0.19–0.45) | 0.08 |