Ocular microvascular changes in patients with sepsis: a prospective observational study

Annals of Intensive Care

Table 3 Differences in microcirculation parameters between survivors and non-survivors

Microcirculation parameter	ICU survivors			p	ICU non-survivors			p
Microcirculation parameter	Baseline (n = 19)	6 h (n = 19)	24 h (n = 19)	p	Baseline (n = 29)	6 h (n = 25)	24 h (n = 18)	p
Conjunctival
Conjunctival TVD (small), mm/mm²	11.3 [9.2–15.2]	10.6 [9.7–13.6]	11.7 [10.7–13.4]	0.481	12.7 [8.9–14.1]	10.1 [7.5–12.6]	9.7 [7.1–15.0]	0.794
PVD (small), mm/mm²	10.0 [8.5–13.7]	10.2 [8.9–12.2]	10.9 [9.6–11.8]	0.257	8.5 [7.0–10.9]	7.6 [5.7–10.3]*	8.3 [5.6–11.4]*	0.735
De Backer score (small), n/mm	7.4 [5.8–9.4]	6.7 [5.6–7.9]	7.0 [6.2–8.2]	0.526	7.0 [5.7–8.9]	6.5 [4.5–7.9]	5.9 [4.1–8.8]	0.500
PPV (small), %	91.5 [88.5–93.2]	92.5 [88.4–95.3]	94.4 [88.9–97.5]	0.191	80.6 [70.8–87.3]*	80.8 [70.2–89.3]*	84.1 [72.0–90.1]*	0.735
MFI (small), AU	2.58[ 2.46–2.83]	2.87 [2.64–2.93]^a	2.92 [2.65–3.00]^a	0.004	2.25 [1.75–2.50]*	2.25 [1.98–2.59]*	2.50 [2.05–2.59]*	0.640
Retinal
CRAE, μm	164 [151–189]	166 [152–194]	162 [148–182]	0.344	170 [154–188]	162 [146–175]	175 [147–195]	0.420
CRVE, µm	267 [240–302]	288 [254–306]	266 [236–281]	0.627	245 [223–281]	250 [236–282]*	262 [222–287]	0.627
Vascular length density, %	0.52 [0.43–0.63]	0.55 [0.49–0.60]	0.50 [0.42–0.59]	0.766	0.50 [0.44–0.56]	0.43 [0.40–0.56]*^a	0.46 [0.39–0.55]^a	0.188

Data are presented as median [IQR]
TVD total vascular density, PVD perfused vascular density, PPV proportion of perfused vessels, MFI microcirculatory flow index, CRAE central retinal arteriolar equivalent, CRVE central retinal venular equivalent
*p < 0.05 between survivors and non-survivors; ^ap < 0.05 in comparison with baseline