Table 1 Population characteristics
All patients (n = 158) | Without MAKE-360 (n = 21) | With MAKE-360 (n = 120) | |
|---|---|---|---|
Women/men | 24.1/75.9 | 2/19 | 33/87 |
Weight (kg) | 77 [65; 90] | 74 [65; 85] | 78 [66; 90] |
Height (cm) | 170 [165; 178] | 178 [169; 180.5] | 170 [165; 177] |
Body mass index (kg/m2) | 26.2 [22.9; 30] | 24.4 [20.6; 26.4] | 26.8 [23.8; 30.5] |
Age (years) | 59 [47; 66] | 49 [39; 56] | 60 [49.5; 66.5] |
Length of ICU stay (days) | 20.5 [12; 39] | 19 [14; 39] | 21 [12; 38.5] |
SAPS-II at ICU admission | 54.5 [39; 66] | 39 [21; 60] | 55.5 [40.5; 68] |
SOFA at ICU admission | 9 [7; 12] | 8 [5; 10] | 9.5 [7; 12] |
Respiratory item | 1 [0; 2] | 1 [0; 2] | 2 [1; 3] |
Neurologic item | 0 [0; 1] | 0 [0; 2] | 0 [0; 1] |
Hemodynamic item | 4 [3; 4] | 4 [2; 4] | 4 [3; 4] |
Liver item | 1 [0; 2] | 1 [0; 2] | 1 [0; 2] |
Kidney item | 1 [0; 2] | 0 [0; 1] | 1 [0; 2] |
Coagulating item | 1 [0; 2] | 0 [0; 2] | 1 [0; 2] |
Known comorbidities | |||
Previous myocardial infarction | 45 (28.5) | 2 (9.5) | 37 (30.8) |
Chronic cardiac failure | 93 (58.9) | 7 (33.3) | 77 (64.2) |
Peripheral vascular disease | 19 (12) | 1 (4.8) | 16 (13.3) |
Dementia | 1 (0.6) | 0 (0) | 1 (0.8) |
Cerebrovascular disease | 20 (12.7) | 1 (4.8) | 18 (15) |
Chronic respiratory disease | 29 (18.4) | 2 (9.5) | 24 (20) |
Connectivitis | 6 (3.8) | 3 (14.3) | 2 (1.7) |
Ulcers | 11 (7) | 0 (0) | 10 (8.3) |
Chronic liver disease | 3 (1.9) | 0 (0) | 3 (2.5) |
Diabetes | 44 (27.8) | 3 (14.3) | 38 (31.7) |
Hemiplegia | 2 (1.3) | 0 (0) | 2 (1.7) |
Moderate-to-severe renal failure | 34 (21.5) | 0 (0) | 32 (26.7) |
Solid tumor | 6 (3.8) | 0 (0) | 6 (5) |
Leukemia | 1 (0.6) | 1 (4.8) | 0 (0) |
Lymphoma | 1 (0.6) | 0 (0) | 1 (0.8) |
AIDS | 0 | 0 | 0 |
Hypertension | 62 (39.2) | 3 (14.3) | 53 (44.2) |
Active smoking | 23 (14.6) | 4 (19) | 17 (14.2) |
Dyslipidemia | 50 (31.6) | 3 (14.3) | 41 (34.2) |
Alcoholism | 10 (6.3) | 3 (14.3) | 6 (5) |
Duration of CBP (min)* | 148.5 [109; 210] | 140 [89; 177] | 155 [116; 220] |
No CBP | 90 (60) | 11 (55) | 71 (62.8) |
CBP ≤ 140 min | 28 (18.7) | 4 (20) | 20 (17.7) |
CBP > 140 min | 40 (25.3) | 5 (25) | 22 (19.5) |
Duration of aortic clamping (min)* | 81.5 [56.5; 114.5] | 102.5 [55; 127] | 81 [56; 111] |
Place of cannulation | |||
In ICU | 29 (18.4) | 1 (4.8) | 22 (18.3) |
Operative bloc | 116 (73.4) | 18 (85.7) | 88 (73.3) |
Other | 13 (8.2) | 2 (9.5) | 10 (8.3) |
Cannulation site | |||
Femoro-femoral | 66 (41.8) | 10 (47.6) | 45 (37.5) |
Other | 92 (58.2) | 11 (52.4) | 75 (62.5) |
Time from ICU admission to cannulation (days) | 1 [1; 1] | 1 [1; 1] | 1 [1; 2] |
ECMO duration (days) | 7.5 [4; 12] | 6 [3; 8] | 8 [5; 13] |
Recannulation | 31 (19.6) | 3 (14.3) | 28 (23.3) |
Mechanical ventilation at cannulation | 123 (77.8) | 16 (76.2) | 92 (76.7) |
SOFA at cannulation | 9 [7; 12] | 9 [6; 10] | 9 [7; 12] |
Respiratory item | 2 [1; 3] | 2 [1; 2] | 2 [1; 3] |
Neurological item | 0 [0; 4] | 0 [0; 4] | 0 [0; 4] |
Hemodynamic item | 4 [4; 4] | 4 [4; 4] | 4 [4; 4] |
Liver item | 0 [0; 2] | 1 [0; 2] | 0 [0; 2] |
Kidney item | 1 [0; 2] | 0 [0; 1] | 1 [0; 2] |
Coagulation item | 0 [0; 1] | 0 [0; 1] | 0 [0; 1] |
SOFA without hemodynamic score | 5 [3; 8] | 5 [3; 6] | 5 [3; 8] |
Biological features at cannulation | |||
Lactate (mmol/l) | 3 [2.2; 5.4] | 3.1 [3; 6.1] | 3 [2.2; 4.5] |
AST (UI/l) | 93.5 [47; 262] | 94 [60; 437] | 93.5 [45.5; 276.5] |
ALT (UI/l) | 68 [35; 216] | 68 [36; 289] | 68 [34.5; 186] |
Platelets count (g/l) | 163 [123; 228] | 187 [104; 232] | 162 [123; 225] |
≤ 50 g/l | 7 (4.4) | 2 (9.5) | 5 (4.2) |
> 50 g/l | 61 (38.6) | 6 (28.6) | 48 (40) |
> 150 g/l | 90 (57) | 13 (61.9) | 67 (55.8) |
Hemoglobin (g/dl) | 10 [7.9; 12.3] | 9.8 [7.2; 10.4] | 10 [8; 12.6] |
≤ 10 g/dl | 81 (51.3) | 11 (52.4) | 61 (50.8) |
> 10 g/dl | 77 (48.7) | 10 (47.6) | 59 (49.2) |
Leukocytes (g/l) | 10.9 [6.9; 16.4] | 11.5 [8; 14.6] | 10.5 [6.8; 16.3] |
PT (%) | 58 [41; 75] | 60 [49; 74] | 58 [40; 74] |
aPTT ratio | 1..4 [1.2; 1.7] | 1.2 [1.1; 1.4] | 1.4 [1.2; 1.8] |
Hemorrhagic shock | 79 (50) | 8 (38.1) | 64 (53.3) |
Other than hemopericardium | 43 (27.2) | 5 (23.8) | 35 (29.2) |
Early hemopericardium | 24 (15.2) | 1 (4.8) | 21 (17.5) |
Late hemopericardium | 12 (7.6) | 2 (9.5) | 8 (6.7) |
Number of RBC | 9 [5; 19] | 5 [4; 10] | 12 [6; 22] |
ECMO duration (days) | 7.5 [4; 12] | 6 [3; 8] | 8 [5; 13] |
Outcomes | |||
Bridge to VAD | 10 (6.3) | 2 (9.5) | 8 (6.7) |
Bridge to heart transplantation | 19 (12) | 2 (9.5) | 17 (14.2) |
ECMO weaning | 80 (50.6) | 17 (81) | 46 (38.3) |
No weaning | 49 (31) | 0 (0) | 49 (40.8) |