Factors associated with major adverse kidney events in patients who underwent veno-arterial extracorporeal membrane oxygenation

Annals of Intensive Care

Table 2 Multivariate logistic regression analysis: independent predictors of major adverse kidney events (MAKE) at day 30, at day 60, and at day 360

Variables	MAKE30^a		MAKE90^a		MAKE360^b
Variables	OR [95% CI]	p value	OR [95% CI]	p value	OR [95% CI]	p value
eGFR at baseline (by mL/min/1.73 m²)	0.99 [0.98–1.00]	0.25	0.99 [0.98–1.00]	0.04	0.98 [0.97–1.00]	0.02
KDIGO stage at cannulation		< 0.01		0.12		0.03
Stage 0	1		1		1
Stage 1	3.58 [1.28–10.00]		1.31 [0.47–3.60]		4.47 [0.99–20.20]
Stage 2	4.95 [1.28–19.12]		3.26 [0.78–13.61]		3.04 [0.51–18.14]
Stage 3	5.73 [2.12–15.50]		2.86 [1.07–7.65]		10.20 [1.77–58.87]
SOFA score without hemodynamic and renal items	1.06 [0.91–1.23]	0.43	1.06 [0.91–1.23]	0.46	0.87 [0.69–1.09]	0.23
aPTT ratio at cannulation	1.05 [0.68–1.60]	0.83	1.38 [0.86–2.20]	0.17	1.17 [0.57–2.39]	0.67
Duration of CBP		0.38		0.08		0.69
Duration of CBP ≥ 140 min	1		1		1
No CBP	1.98 [0.74–5.29]		3.01 [1.11–8.17]		1.89 [0.45–7.97]
Duration of CBP < 140 min	1.68 [0.55–5.12]		1.51 [0.49–4.62]		1.44 [0.28–7.47]
Number of RBC packs received while under ECMO	1.09 \|1.03–1.15]	< 0.01	1.08 [1.02–1.15]	< 0.01	1.14 [1.01–1.28]	0.03
ECMO duration	0.99 [0.93–1.06]	0.78	1.03 [0.95–1.10]	0.48	1.04 [0.92–1.17]	0.54

Adjustment on eGFR at baseline, KDIGO stage at cannulation, SOFA score without hemodynamic and renal items, aPTT ratio at cannulation, duration of CBP, number of RBC packs while under ECMO, ECMO duration
OR odds ratio, IC interval confidence, VA-ECMO veno-arterial extracorporeal membrane oxygenation, RRT renal replacement therapy, OR odds ratio, CI confidence interval, SOFA sepsis-related organ failure assessment score, KDIGO kidney disease: improving global outcomes, RBC red blood cells, aPTT activated partial thromboplastin time, CBP cardiopulmonary bypass, eGFR estimated glomerular filtration rate
^aDefined as one of the following criteria within day 30 or day 90: death, receipt of renal replacement therapy and serum creatinine ≥ threefold increase
^bDefined as one of the following criteria within 1 year: death and receipt of renal replacement therapy (RRT) or persistent renal dysfunction, i.e., CKD ≥ stage 3 corresponding to an eGFR by MDRD ≤ 60 ml/min/1.73 m²