Fig. 1

Relative risk of death at day-90 according to pre-vasopressor diastolic shock index (Pre-VPs/DSI) or vasopressor start (VPs/DSI) partitions in the preliminary and ANDROMEDA SHOCK populations. Diastolic shock index values obtained from just before the start of vasopressor (in preliminary cohort) and at the start vasopressor support (in ANDROMEDA-SHOCK) were partitioned into 5 quantiles (Q1 to Q5). Distribution of heart rate (HR) and diastolic pressure (DAP) (top) and their respective diastolic shock index distribution (middle) are presented through the quantile distribution. Boxplots (top and middle) delineate the interquartile range, the median is shown as a line in the middle of the box, and tails represent the 95% range. Coefficients derived from a logistical regression were used to calculate the cut-off value of the diastolic shock index (DSI) detecting the mean risk of mortality of the entire population at 28 days. This point was used as the reference to calculate the adjusted relative risks, in such a way that a relative risk of 1 represents the mean risk of the respective population (bottom). The mean risk and 95% confidence interval (error bars at the bottom) for each percentile were calculated after multivariate adjustment (Cox proportional-hazards model) for the covariables: age, gender, SOFA score day-1, initial arterial lactate and pH, and resuscitation fluids from VP to 8H. The gray zone represents the 95% confidence interval for the Cox regression (continuous line) across the complete population, assuming the diastolic shock index as a continuous variable. Note that adjusted relative risk of death increases as diastolic shock index also does through the quintile distribution