Table 2 Characteristics of intermittent hemodialysis sessions
All | First | Later | P | |
|---|---|---|---|---|
Number of sessions | 211 | 72 | 139 | |
Number of days since ICU admission | 8 [3–12] | 3 [2–5] | 10 [7–15] | < 0.0001 |
SOFA score (without renal points) | 6 [2–11] | 8 [4–13] | 4 [1–9] | 0.0001 |
Organ support therapy at T0 | ||||
Invasive mechanical ventilation | 130 (62%) | 48 (67%) | 82 (59%) | 0.30 |
Vasopressors | 90 (43%) | 44 (61%) | 46 (30%) | 0.0001 |
Norepinephrine | 80 (38%) | 36 (50%) | 44 (32%) | |
Epinephrine | 10 (5%) | 8 (11%) | 2 (1%) | |
Cardiovascular SOFA score ≥ 1 at T0 | 104 (49%) | 48 (67%) | 56 (40%) | 0.0003 |
Tissue perfusion parameters at T0 | ||||
Lactate > 2 mmol/L | 49 (23%) | 33 (46%) | 16 (12%) | < 0.0001 |
Index capillary refill time ≥ 3 s | 38 (18%) | 23 (32%) | 15 (11%) | 0.0003 |
Hemodialysis settings | ||||
Duration (hours) | 4 [4–4] | 4 [4–4] | 4 [4–5] | 0.015 |
Ultrafiltration | 135 (64%) | 25 (35%) | 110 (79%) | < 0.0001 |
Volume of ultrafiltration (L) | 2.5 [2.0–3.0] | 2.0 [1.6–3.0] | 2.6 [2.0–3.1] | 0.10 |
Intradialytic hemodynamic instability | 48 (23%) | 31 (43%) | 17 (12%) | < 0.0001 |
Timing of first hemodynamic instability | 0.092 | |||
Before first hour | 35 (73%) | 24 (77%) | 4 (24%) | |
Between first and second hour | 6 (13%) | 3 (10%) | 1 (6%) | |
Between second and fourth hour | 7 (14%) | 4 (13%) | 3 (18%) | |
Therapeutic interventions (not exclusive) | ||||
Increase in vasopressors | 35 (73%) | 24 (77%) | 11 (65%) | |
Fluid administration | 15 (31%) | 13 (42%) | 2 (12%) | |
Initiation of vasopressors | 7 (15%) | 5 (16%) | 2 (12%) | |
Decrease in ultrafiltration | 3 (6%) | 0 | 3 (18%) | |
Cessation of ultrafiltration | 3 (6%) | 0 | 3 (18%) | |