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Annals of Intensive Care
Fig. 3 | Annals of Intensive Care

Fig. 3

From: Acute-on-chronic liver failure alters meropenem pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study

Fig. 3

Deterministic simulations of meropenem. a 1 g quid 8 h (30 min); b 2 g loading dose (30 min) followed by 1 g prolonged infusion (over 4 h) quid 8 h; c 2 g quid 8 h (30 min); d 2 g loading dose (30 min) followed by continuous infusion of 3 g/day. Solid lines: typical patient without liver failure; dashed line: typical acute-on-chronic liver failure patient; dotted horizontal line depict typical target concentrations as 4x European Committee on Antimicrobial Susceptibility Testing epidemiological cut-off values (ECOFF) for Pseudomonas spp. (4× ECOFF 2.0 mg/L = 8 mg/L)

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