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Table 1 Baseline characteristics and their univariate association with 1-year survival tested by Cox proportional hazard model

From: One-year survival in acute stroke patients requiring mechanical ventilation: a multicenter cohort study

Variable

N (%) or median [Q1; Q3]

All

N = 419

1-year survival

Alive

N = 114

Dead

N = 305

HR (95% CI)

p

Demographics/history

 Age, years

68.2 [57.9; 76.3]

67.2 [57.4; 74.8]

69.1 [58.4; 76.9]

1.00 (0.99; 1.00)

0.35

 Male sex

251 (59.9)

66 (57.9)

185 (60.7)

1.01 (0.81; 1.27)

0.93

 Hypertension

238 (57.3)

72 (63.2)

166 (55.1)

1.20 (0.95; 1.52)

0.12

 Diabetes mellitus

81 (19.3)

21 (18.4)

60 (19.7)

1.05 (0.79; 1.39)

0.72

 Atrial fibrillation/flutter

55 (13.3)

13 (11.4)

42 (14)

0.86 (0.63; 1.19)

0.38

 BMI ≥ 30 kg/m2

62 (15.3)

15 (13.5)

47 (16)

0.91 (0.67; 1.25)

0.57

 Charlson comorbidity index ≥ 1

215 (51.3)

63 (55.3)

152 (49.8)

1.16 (0.93; 1.45)

0.20

Stroke characteristics

 Stroke type

  Ischemic

191 (45.6)

66 (57.9)

125 (41)

Ref

< .01

  Hemorrhagic

178 (42.5)

35 (30.7)

143 (46.9)

0.58 (0.45; 0.74)

.

  SAH

50 (11.9)

13 (11.4)

37 (12.1)

0.59 (0.41; 0.85)

.

  Acute-phase stroke therapy

70 (16.7)

33 (28.9)

37 (12.1)

1.96 (1.39; 2.78)

< .01

  Time from stroke to ICU admission, days

1 [1, 2]

1.5 [1, 5]

1 [1, 2]

1.05 (1.02; 1.09)

< .01

ICU admission

 Period of admission

  1996–2002

34 (8.1)

9 (7.9)

25 (8.2)

Ref

0.55

  2003–2009

228 (54.4)

64 (56.1)

164 (53.8)

0.83 (0.54; 1.25)

.

  2010–2016

157 (37.5)

41 (36)

116 (38)

0.79 (0.51; 1.2)

.

 Type of ICU admission

  Transfer from ward

150 (35.8)

56 (49.1)

94 (30.8)

Ref

< .01

  Direct (from ED or home)

269 (64.2)

58 (50.9)

211 (69.2)

0.63 (0.5; 0.81)

.

 Reason for intubation

  Elective procedure

12 (2.9)

10 (8.8)

2 (0.7)

Ref

< .01

  Altered mental status

302 (72.1)

66 (57.9)

236 (77.4)

0.12 (0.03; 0.47)

.

  Respiratory failure

52 (12.4)

19 (16.7)

33 (10.8)

0.19 (0.05; 0.79)

.

  Seizure

34 (8.1)

19 (16.7)

15 (4.9)

0.30 (0.07; 1.33)

.

  Cardiac arrest

19 (4.5)

0 (0)

19 (6.2)

0.04 (0.01; 0.17)

.

 GCS at admission

  8–15

110 (26.3)

57 (50)

53 (17.4)

Ref

< .01

  3–7

309 (73.7)

57 (50)

252 (82.6)

0.36 (0.27; 0.49)

.

  SAPS 2

58 [47; 72]

46.5 [39; 58]

62 [53; 75]

0.95 (0.95; 0.96)

< .01

  Non-neurologic SOFA

4 [1, 6]

3 [1, 6]

4 [2, 6]

1.03 (0.99; 1.07)

0.14

  1. HR, hazard ratio; CI, confidence interval; BMI, body max index; SAH, subarachnoid hemorrhage; ICU, intensive care unit; ED, emergency department; GCS, Glasgow coma scale; SAPS, simplified acute physiology score; SOFA, Sequential Organ Failure Assessment