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Annals of Intensive Care

Table 4 Characteristics of the 41 zygomycosis in patients with hematological malignancy

From: Mucormycosis in intensive care unit: surgery is a major prognostic factor in patients with hematological malignancy

 

Patients with hematological malignancies (n = 41)

Patients who survived (n = 7)

Patients who did not survived (n = 34)

P-value

Age, mean (SD)a

48.4 (15.0)

34.7 (16.3)

51.3 (13.3)

0.04

Sex-ratio

2.4

1.3

2.8

0.40

Malnutrition, n (%)

14 (34.1)

1 (14.3)

13 (38.2)

0.39

Diabetes, n (%)

7 (17.1)

0 (0)

7 (20.6)

0.32

Graft-versus-host disease, n (%)

12 (29.3)

1 (14.3)

11 (32.4)

0.65

Previous antifungal therapy, n (%)

24 (58.5)

0 (0)

24 (70.6)

< 0.001

Site of infection

  

 Lungs, n (%)

19 (48.8)

4 (57.1)

16 (47.1)

0.70

 Skin, n (%)

3 (7.3)

1 (14.3)

2 (5.9)

0.44

 Sinus and ENT infection, n (%)

1 (2.4)

1 (14.3)

0 (0)

0.17

 Abdomen, n (%)

1 (2.4)

0 (0)

1 (2.9)

1

 Bones, n (%)

0 (0)

0 (0)

0 (0)

1

 Contiguous infection of > 1 organ, n (%)

6 (14.6)

1 (14.3)

5 (14.7)

1

Disseminated infection, n (%)

10 (24.4)

0 (0)

10 (29.4)

0.16

Isolated fungi

0.19

 Rhizopus sp., n (%)

15 (36.6)

1 (14.3)

14 (41.2)

 

 Mucor sp., n (%)

2 (4.9)

0 (0)

2 (5.9)

 

 Rhizomucor sp., n (%)

11 (26.8)

2 (28.6)

9 (26.5)

 

 Lichtheimia sp., n (%)

7 (17.1)

1 (14.3)

6 (17.6)

 

 Cunninghamella sp., n (%)

1 (2.4)

0 (0)

1 (2.9)

 

 Not identified zygomycetes, n (%)

5 (12.2)

3 (42.9)

2 (5.9)

 

Severity of infection

 SAPS2, mean (SD)a

55.3 (21.0)

31.4 (22.4)

60.3 (21.0)

< 0.001

 SOFA, mean (SD)a

9.2 (4.2)

4.0 (4.5)

10.1 (4.3)

0.002

 Respiratory

2.0 (1.1)

0.9 (0.9)

2.3 (1.0)

0.005

 Cardiovascular

1.3 (1.8)

0.2 (0.4)

1.5 (1.8)

< 0.001

 Renal

0.9 (1.1)

0.7 (1.0)

0.9 (1.1)

0.61

 Hematological

2.8 (1.2)

1.5 (1.6)

3.1 (1.0)

0.07

 Neurological

1.0 (1.4)

0.1 (0.4)

1.2 (1.5)

0.001

 Liver

1.0 (0.9)

0.7 (0.8)

1.1 (1.0)

0.29

Biological abnormalities

 

 TP < 50%, n (%)

7 (17.1)

0 (0)

7 (20.6)

0.32

 Thrombocytes < 50G/L, n (%)

24 (58.5)

2 (28.6)

22 (64.7)

0.11

 Leucocytes < 1G/L, n (%)

21 (51.2%)

1 (14.3)

20 (58.8)

0.04

Interventions

 Surgical intervention, n (%)

12 (29.3)

6 (85.7)

6 (17.6)

0.001

 Cutaneous resection

2 (4.9)

0

2 (5.9)

1

 Lung resection

5 (12.2)

5 (71.4)

0

< 0.001

ENT resection

3 (7.3)

1 (14.3)

2 (5.9)

0.44

 Abdominal resection

2 (4.9)

0

2 (5.9)

1

 Vasopressors, n (%)

27 (65.9)

0 (0)

27 (79.4)

< 0.001

 Mechanical ventilation, n (%)

35 (85.4)

1 (14.3)

34 (100)

<0.001

 Renal replacement, n (%)therapy

12 (29.3)

0 (0)

12 (35.3)

0.08

  1. Italic values indicate significance of P-value (P < 0.05)
  2. ENT ear-nose-throat, SAPS2 simplified Acute Physiological Score 2, SOFA sequential organ failure assessment
  3. aResults are expressed as mean (SD) and compared with Student’s t test
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