Skip to main content

Table 4 Characteristics of the 41 zygomycosis in patients with hematological malignancy

From: Mucormycosis in intensive care unit: surgery is a major prognostic factor in patients with hematological malignancy

 Patients with hematological malignancies (n = 41)Patients who survived (n = 7)Patients who did not survived (n = 34)P-value
Age, mean (SD)a48.4 (15.0)34.7 (16.3)51.3 (13.3)0.04
Sex-ratio2.41.32.80.40
Malnutrition, n (%)14 (34.1)1 (14.3)13 (38.2)0.39
Diabetes, n (%)7 (17.1)0 (0)7 (20.6)0.32
Graft-versus-host disease, n (%)12 (29.3)1 (14.3)11 (32.4)0.65
Previous antifungal therapy, n (%)24 (58.5)0 (0)24 (70.6)< 0.001
Site of infection  
 Lungs, n (%)19 (48.8)4 (57.1)16 (47.1)0.70
 Skin, n (%)3 (7.3)1 (14.3)2 (5.9)0.44
 Sinus and ENT infection, n (%)1 (2.4)1 (14.3)0 (0)0.17
 Abdomen, n (%)1 (2.4)0 (0)1 (2.9)1
 Bones, n (%)0 (0)0 (0)0 (0)1
 Contiguous infection of > 1 organ, n (%)6 (14.6)1 (14.3)5 (14.7)1
Disseminated infection, n (%)10 (24.4)0 (0)10 (29.4)0.16
Isolated fungi0.19
 Rhizopus sp., n (%)15 (36.6)1 (14.3)14 (41.2) 
 Mucor sp., n (%)2 (4.9)0 (0)2 (5.9) 
 Rhizomucor sp., n (%)11 (26.8)2 (28.6)9 (26.5) 
 Lichtheimia sp., n (%)7 (17.1)1 (14.3)6 (17.6) 
 Cunninghamella sp., n (%)1 (2.4)0 (0)1 (2.9) 
 Not identified zygomycetes, n (%)5 (12.2)3 (42.9)2 (5.9) 
Severity of infection
 SAPS2, mean (SD)a55.3 (21.0)31.4 (22.4)60.3 (21.0)< 0.001
 SOFA, mean (SD)a9.2 (4.2)4.0 (4.5)10.1 (4.3)0.002
 Respiratory2.0 (1.1)0.9 (0.9)2.3 (1.0)0.005
 Cardiovascular1.3 (1.8)0.2 (0.4)1.5 (1.8)< 0.001
 Renal0.9 (1.1)0.7 (1.0)0.9 (1.1)0.61
 Hematological2.8 (1.2)1.5 (1.6)3.1 (1.0)0.07
 Neurological1.0 (1.4)0.1 (0.4)1.2 (1.5)0.001
 Liver1.0 (0.9)0.7 (0.8)1.1 (1.0)0.29
Biological abnormalities 
 TP < 50%, n (%)7 (17.1)0 (0)7 (20.6)0.32
 Thrombocytes < 50G/L, n (%)24 (58.5)2 (28.6)22 (64.7)0.11
 Leucocytes < 1G/L, n (%)21 (51.2%)1 (14.3)20 (58.8)0.04
Interventions
 Surgical intervention, n (%)12 (29.3)6 (85.7)6 (17.6)0.001
 Cutaneous resection2 (4.9)02 (5.9)1
 Lung resection5 (12.2)5 (71.4)0< 0.001
ENT resection3 (7.3)1 (14.3)2 (5.9)0.44
 Abdominal resection2 (4.9)02 (5.9)1
 Vasopressors, n (%)27 (65.9)0 (0)27 (79.4)< 0.001
 Mechanical ventilation, n (%)35 (85.4)1 (14.3)34 (100)<0.001
 Renal replacement, n (%)therapy12 (29.3)0 (0)12 (35.3)0.08
  1. Italic values indicate significance of P-value (P < 0.05)
  2. ENT ear-nose-throat, SAPS2 simplified Acute Physiological Score 2, SOFA sequential organ failure assessment
  3. aResults are expressed as mean (SD) and compared with Student’s t test