Table 2 Cox regression model adjusted for patient characteristics and therapeutic variables for hospital mortality

ICU management policy

 Closed

Reference

 Open

1.113

0.919–1.348

0.275

 Other

0.744

0.584–0.947

0.017

Admission route to the ICU

 Emergency department

Reference

 Another hospital

0.877

0.713–1.078

0.211

 Ward

0.981

0.812–1.187

0.847

Age (years)

1.013

1.006–1.020

< 0.001

Male sex

1.125

0.947–1.337

0.179

Body weight (kg)

0.991

0.984–0.997

0.004

Pre-existing organ insufficiency or immunosuppression based on APACHE II score

 Liver

1.278

0.952–1.716

0.102

 Respiratory

1.422

1.020–1.983

0.038

 Cardiovascular

1.354

1.024–1.790

0.034

 Renal

1.460

1.132–1.885

0.004

 Immunocompromised

1.081

0.864–1.352

0.497

Pre-existing haemostatic disorders

 Haematological malignancy

1.118

0.771–1.619

0.556

 Chemotherapy

0.982

0.710–1.360

0.915

 Warfarin intake

0.776

0.524–1.150

0.206

 Other

1.464

0.939–2.283

0.093

APACHE II score

1.035

1.023–1.047

< 0.001

SOFA score

1.088

1.054–1.123

< 0.001

SIRS score

0.953

0.869–1.047

0.316

JAAM-DIC score

1.032

0.987–1.079

0.161

Blood lactate (mmol/L)

1.083

1.066–1.100

< 0.001

Blood culture

 Not taken

Reference

 Positive

1.083

0.690–1.700

0.728

 Negative

0.885

0.573–1.365

0.581

Microorganisms

 Unknown

Reference

 Virus

0.945

0.400–2.231

0.898

 Gram-negative rod

0.791

0.612–1.023

0.074

 Gram-positive coccus

0.902

0.685–1.188

0.463

 Fungus

1.158

0.644–2.083

0.625

 Mixed infection

1.034

0.784–1.364

0.810

 Others

1.126

0.642–1.975

0.678

Primary source of infection

 Unknown

Reference

 Catheter-related bloodstream infection

0.631

0.317–1.254

0.189

 Bone or soft tissue

0.765

0.525–1.116

0.165

 Cardiovascular system

0.566

0.289–1.109

0.097

 Central nervous system

0.579

0.328–1.023

0.060

 Urinary tract

0.538

0.364–0.794

0.002

 Lung or thoracic cavity

1.084

0.803–1.464

0.598

 Abdomen

0.774

0.555–1.079

0.131

 Other

0.625

0.290–1.348

0.231

Specific treatments

 Surgical intervention

0.766

0.619–0.948

0.014

 Mechanical ventilator (days)

0.977

0.967–0.987

< 0.001

 Vasopressor

1.290

0.979–1.701

0.070

 Immunoglobulins

0.859

0.719–1.027

0.095

 Low-dose steroids

1.420

1.190–1.695

< 0.001

Therapeutic interventions for DIC

 ART-123

0.834

0.695–0.999

0.049

 Antithrombin

0.875

0.728–1.053

0.158

 Protease inhibitors

0.916

0.727–1.152

0.452

 Heparinoids

1.014

0.706–1.457

0.940

Anti-thrombotic drugs for conditions other than DIC

 Heparin

0.690

0.537–0.886

0.004

 Anti-platelet drugs

0.646

0.342–1.221

0.179

 Nafamostat mesylate for blood purifications

0.702

0.553–0.889

0.003

Blood purifications

 PMX-HP

0.897

0.720–1.118

0.333

 RRT

1.383

1.090–1.756

0.008

 RRT for non-renal indications

1.300

0.992–1.704

0.057

 Plasma exchange

1.498

0.838–2.677

0.172