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Table 4 Cox regression model adjusted for patient characteristics and therapeutic variables to assess hospital mortality in patients who received vasopressors

From: Beneficial effect modification on survival outcome of sepsis between ART-123 and polymyxin B‑immobilised haemoperfusion: a nationwide Japanese registry study

 Adjusted hazard ratio95% confidence intervalP value
ICU management policy
 ClosedReference
 Open1.0760.876–1.3200.486
 Other0.7460.579–0.9620.024
Admission route to the ICU
 Emergency departmentReference
 Another hospital0.8580.689–1.0690.172
 Ward0.9650.791–1.1780.727
Age (years)1.0141.007–1.022< 0.001
Male sex1.2191.015–1.4640.034
Body weight (kg)0.9920.986–0.9990.027
Pre-existing organ insufficiency or immunosuppression based on APACHE II score
 Liver1.2100.888–1.6490.228
 Respiratory1.4120.997–1.9980.052
 Cardiovascular1.4131.061–1.8830.018
 Renal1.4671.120–1.9220.005
 Immunocompromised1.0880.861–1.3760.479
Pre-existing haemostatic disorders
 Haematological malignancy1.0700.720–1.5910.737
 Chemotherapy0.9810.699–1.3770.912
 Warfarin intake0.8070.540–1.2070.296
 Other1.2020.716–2.0190.486
APACHE II score1.0371.025–1.051< 0.001
SOFA score1.0781.043–1.115< 0.001
SIRS score0.9580.868–1.0580.400
JAAM-DIC score1.0290.982–1.0790.226
Blood lactate (mmol/L)1.0831.065–1.101< 0.001
Blood culture
 Not takenReference
 Positive1.0220.623–1.6780.930
 Negative0.8130.504–1.3130.398
Microorganisms
 UnknownReference
 Virus0.6920.245–1.9560.488
 Gram-negative rod0.8000.607–1.0520.111
 Gram-positive coccus0.9390.699–1.2620.678
 Fungus1.2450.683–2.2690.474
 Mixed infection1.0310.764–1.3900.843
 Others1.0610.566–1.9900.853
Primary source of infection
 UnknownReference
 Catheter-related bloodstream infection0.6530.325–1.3120.232
 Bone or soft tissue0.8160.547–1.2180.320
 Cardiovascular system0.5770.284–1.1710.128
 Central nervous system0.7080.379–1.3230.279
 Urinary tract0.5440.357–0.8300.005
 Lung or thoracic cavity1.1140.807–1.5370.512
 Abdomen0.7840.551–1.1160.176
 Other0.6320.277–1.4390.274
Specific treatments
 Surgical intervention0.7670.614–0.9580.019
 Mechanical ventilator (days)0.9740.964–0.985< 0.001
 Immunoglobulins0.8850.735–1.0660.198
 Low-dose steroids1.3871.154–1.666< 0.001
Therapeutic interventions for DIC
 ART-1230.8490.704–1.0250.089
 Antithrombin0.8850.730–1.0720.210
 Protease inhibitors0.8930.702–1.1370.358
 Heparinoids1.0450.709–1.5420.823
Anti-thrombotic drugs for conditions other than DIC
 Heparin0.6960.536–0.9040.007
 Anti-platelet drugs0.7060.361–1.3820.310
 Nafamostat mesylate for blood purifications0.6990.547–0.8930.004
Blood purifications
 PMX-HP0.9150.731–1.1460.440
 RRT1.3981.092–1.7890.008
 RRT for non-renal indications1.3231.005–1.7400.046
 Plasma exchange1.6320.864–3.0830.131
  1. APACHE acute physiology and chronic health evaluation, DIC disseminated intravascular coagulation, ECMO extracorporeal membrane oxygenation, ICU intensive care unit, JAAM Japanese Association for Acute Medicine, PMX-HP polymyxin B‑immobilised haemoperfusion, RRT renal replacement therapy, SIRS systemic inflammatory response syndrome, SOFA sequential organ failure assessment