Table 4 Cox regression model adjusted for patient characteristics and therapeutic variables to assess hospital mortality in patients who received vasopressors

ICU management policy

 Closed

Reference

 Open

1.076

0.876–1.320

0.486

 Other

0.746

0.579–0.962

0.024

Admission route to the ICU

 Emergency department

Reference

 Another hospital

0.858

0.689–1.069

0.172

 Ward

0.965

0.791–1.178

0.727

Age (years)

1.014

1.007–1.022

< 0.001

Male sex

1.219

1.015–1.464

0.034

Body weight (kg)

0.992

0.986–0.999

0.027

Pre-existing organ insufficiency or immunosuppression based on APACHE II score

 Liver

1.210

0.888–1.649

0.228

 Respiratory

1.412

0.997–1.998

0.052

 Cardiovascular

1.413

1.061–1.883

0.018

 Renal

1.467

1.120–1.922

0.005

 Immunocompromised

1.088

0.861–1.376

0.479

Pre-existing haemostatic disorders

 Haematological malignancy

1.070

0.720–1.591

0.737

 Chemotherapy

0.981

0.699–1.377

0.912

 Warfarin intake

0.807

0.540–1.207

0.296

 Other

1.202

0.716–2.019

0.486

APACHE II score

1.037

1.025–1.051

< 0.001

SOFA score

1.078

1.043–1.115

< 0.001

SIRS score

0.958

0.868–1.058

0.400

JAAM-DIC score

1.029

0.982–1.079

0.226

Blood lactate (mmol/L)

1.083

1.065–1.101

< 0.001

Blood culture

 Not taken

Reference

 Positive

1.022

0.623–1.678

0.930

 Negative

0.813

0.504–1.313

0.398

Microorganisms

 Unknown

Reference

 Virus

0.692

0.245–1.956

0.488

 Gram-negative rod

0.800

0.607–1.052

0.111

 Gram-positive coccus

0.939

0.699–1.262

0.678

 Fungus

1.245

0.683–2.269

0.474

 Mixed infection

1.031

0.764–1.390

0.843

 Others

1.061

0.566–1.990

0.853

Primary source of infection

 Unknown

Reference

 Catheter-related bloodstream infection

0.653

0.325–1.312

0.232

 Bone or soft tissue

0.816

0.547–1.218

0.320

 Cardiovascular system

0.577

0.284–1.171

0.128

 Central nervous system

0.708

0.379–1.323

0.279

 Urinary tract

0.544

0.357–0.830

0.005

 Lung or thoracic cavity

1.114

0.807–1.537

0.512

 Abdomen

0.784

0.551–1.116

0.176

 Other

0.632

0.277–1.439

0.274

Specific treatments

 Surgical intervention

0.767

0.614–0.958

0.019

 Mechanical ventilator (days)

0.974

0.964–0.985

< 0.001

 Immunoglobulins

0.885

0.735–1.066

0.198

 Low-dose steroids

1.387

1.154–1.666

< 0.001

Therapeutic interventions for DIC

 ART-123

0.849

0.704–1.025

0.089

 Antithrombin

0.885

0.730–1.072

0.210

 Protease inhibitors

0.893

0.702–1.137

0.358

 Heparinoids

1.045

0.709–1.542

0.823

Anti-thrombotic drugs for conditions other than DIC

 Heparin

0.696

0.536–0.904

0.007

 Anti-platelet drugs

0.706

0.361–1.382

0.310

 Nafamostat mesylate for blood purifications

0.699

0.547–0.893

0.004

Blood purifications

 PMX-HP

0.915

0.731–1.146

0.440

 RRT

1.398

1.092–1.789

0.008

 RRT for non-renal indications

1.323

1.005–1.740

0.046

 Plasma exchange

1.632

0.864–3.083

0.131