Recruitability and effect of PEEP in SARS-Cov-2-associated acute respiratory distress syndrome

Annals of Intensive Care

Table 2 Respiratory parameters at inclusion

	All patients, n = 25	Highly recruitable, n = 16	Poorly recruitable, n = 9	p value
VT (ml/kg PBW)	6.0 [5.9–6.1]	6.1 [5.9–6.1]	6 [6–6.3]	0.59
RR/min	28 [26–30]	27.5 [25–30]	30 [28–31]	0.1
VE, L/min	12.3 [9.2–13]	11.9 [9.6–13.6]	12.6 [10.5–14.1]	0.85
FiO₂, %	60 [40–65]	55 [40–70]	60 [45–65]	0.47
PEEP, cmH₂O	12 [10–15]	13 [12–15]	10 [10–12]	0.02
Pplat, cmH₂O	23 [21–24]	23 [20–24]	23 [21–27]	0.32
PaO₂, mmHg	75 [65–94]	77 [68–90]	73 [62–99]	0.9
PaO₂/FiO₂, mmHg	135 [119–195]	140 [123–196]	121 [106–155]	0.43
PaCO₂, mmHg	41 [38–44]	41 [38–42]	40 [36–45]	0.97
Patients with airway closure > 5 cmH₂O, n (%)	6 (24)	4 (25)	2 (22)	1
AOP in patients with airway closure > 5 cmH₂O, cmH₂O	8 [7–10]	8 [7–10]	8 [6–10]	1

Data are presented as median [interquartile range] or number (percentage)
VT tidal volume, PBW predicted body weight, RR respiratory rate, VE minute ventilation, FiO₂ fraction of inspired oxygen, PEEP set positive end-expiratory pressure, Pplat plateau pressure, C_RS compliance of the respiratory system, PaO₂ partial pressure of arterial oxygen, PaCO₂ partial pressure of arterial carbon dioxide, AOP airway opening pressure, R/I ratio recruitment-to-inflation ratio
p-values refer to the comparison between the highly and poorly recruitable patients groups