COVID-19-associated invasive pulmonary aspergillosis

Annals of Intensive Care

Table 1 Patients with suspected IPA

Patient ID	Sex (M/F)	Age	Medical history	Time between COVID-19 symptoms and ICU admission (days)	Time between COVID-19 symptoms and intubation (days)	Time between intubation and first finding of IPA (days)	First BAL galactomannan index	Peak BAL galactomannan index	First serum galactomannan index	Peak serum galactomannan index
1	M	86	Hyperchol	7	7	9	N/A	N/A	0.10	0.10
2	M	38	Obesity, hyperchol	9	9	6	2.40	> 2.80	0.30	0.30
3	M	62	DM	7	7	16	0.72	2.00	0.20	0.20
4	M	73	DM, obesity, AHT, hyperchol	9	10	5	2.65	> 2.80	0.10	0.10
5	M	77	DM, CKD, AHT, pemphigus foliaceus	9	10	2	2.79	2.79	0.10	0.10
6	M	55	HIV, AHT, hyperchol	8	9	13	0.69	0.69	0.18	0.80
7	M	75	AML, IPA (2012)	3	3	8	2.63	2.63	N/A	N/A

Patient ID	Sex (M/F)	Age	Medical history	First positive culture	CT scan	Histological examination^a	IPA diagnosis	AspICU algorithm	Antifungal therapy	Outcome
1	M	86	Hyperchol	A. flavus (ETA)	No scan available	N/A	–	–	None	Died, ICU day 10
2	M	38	Obesity, hyperchol	A. fumigatus (BAL)	+	Positive	Proven	Absolute	Voriconazole, isavuconazole	Alive on MV, ICU day 28^b
3	M	62	DM	A. fumigatus (BAL)	No scan available	Positive	Proven	Absolute	Voriconazole	Died, ICU day 20
4	M	73	DM, obesity, AHT, hyperchol	A. fumigatus (BAL)	No scan available	Positive	Proven	Absolute	Voriconazole	Alive on MV, ICU day 24^b
5	M	77	DM, CKD, AHT, pemphigus foliaceus	A. fumigatus (BAL)	No scan available	Positive	Proven	Absolute	Voriconazole	Alive on MV, ICU day 21^b
6	M	55	HIV, AHT, hyperchol	Negative	No scan available	Negative		–	Voriconazole, isavuconazole	Died, ICU day 27
7	M	75	AML, IPA (2012)	A. fumigatus (BAL)	No scan available	N/A		–	Voriconazole	Died, ICU day 8

CKD chronic kidney disease, AML acute myeloid leukaemia, IPA invasive pulmonary aspergillosis. N/A no sample available, Hyperchol hypercholesterolaemia, AHT arterial hypertension, DM diabetes mellitus, BAL bronchoalveolar lavage, ETA endotracheal aspirate, MV mechanical ventilation arterial hypertension
^aAnatomopathological examination of tissue samples obtained via bronchoscopy
^bAt the time of writing