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Table 2 Factor associated with the use of low tidal volume

From: Organizational factors associated with adherence to low tidal volume ventilation: a secondary analysis of the CHECKLIST-ICU database

 

All patients (n = 5719)

LTVV* (n = 3340)

No LTVV* (n = 2379)

Absolute difference** (95% CI)

p value

Related to the trial

 Use of checklist

1279 (22.4)

843 (25.2)

436 (18.3)

4.41 (− 0.20 to 9.02)

0.061

Related to the hospital

 Tertiary

4605 (81.5)

2742 (83.2)

1863 (79.1)

5.04 (− 2.29 to 12.35)

0.180

 Specialty

1060 (18.8)

691 (21.0)

369 (15.7)

5.61 (− 2.89 to 14.06)

0.197

 University

2202 (39.0)

1309 (39.7)

893 (37.9)

− 2.23 (− 8.57 to 4.12)

0.493

Number of beds

 < 157

1887 (33.4)

1086 (32.9)

801 (34.0)

8.62 (2.08 to 15.17)a

0.011

 157–324

1906 (33.7)

1041 (31.6)

865 (36.7)

 > 324

1857 (32.9)

1169 (35.5)

688 (29.2)

Number of ICU beds

0.445

 < 11

2362 (41.8)

1364 (41.4)

998 (42.4)

1.85 (− 5.17 to 8.87)b

0.606

 11–21

1774 (31.4)

1028 (31.2)

746 (31.7)

 > 21

1514 (26.8)

904 (27.4)

610 (25.9)

Related to organization

 Multidisciplinary rounds

3444 (60.2)

2068 (61.9)

1376 (57.8)

− 0.15 (− 3.63 to 3.34)

0.932

 Sedation protocol

2620 (46.4)

1509 (45.8)

1111 (47.2)

− 2.02 (− 8.08 to 4.02)

0.514

 Analgesia protocol

2285 (40.4)

1342 (40.7)

943 (40.1)

2.18 (− 3.99 to 8.37)

0.490

 Weaning protocol

3644 (64.5)

2090 (63.4)

1554 (66.0)

− 1.36 (− 7.73 to 5.02)

0.677

 VAP protocol

3621 (64.1)

2046 (62.1)

1575 (66.9)

− 3.58 (− 9.89 to 2.74)

0.269

Board-certified consultant

 None

371 (6.6)

204 (6.2)

167 (7.1)

4.11 (− 1.92 to 10.15)c

0.185

 Full-time

3015 (53.4)

1821 (55.2)

1194 (50.7)

 Half-time

2264 (40.1)

1271 (38.6)

993 (42.2)

 1:10 physician

5466 (96.7)

3205 (97.2)

2261 (96.0)

6.74 (− 8.75 to 22.22)

0.395

 Board-certified RT coordinator

3920 (69.4)

2309 (70.1)

1611 (68.4)

− 2.69 (− 9.41 to 4.06)

0.436

1:10 respiratory therapist

 None

108 (1.9)

69 (2.1)

39 (1.7)

− 2.53 (− 8.59 to 3.53)c

0.415

 Full-time

2438 (43.2)

1383 (42.0)

1055 (44.8)

 Half-time

3104 (54.9)

1844 (55.9)

1260 (53.5)

 1:10 nurse

5482 (97.0)

3227 (97.9)

2255 (95.8)

20.24 (3.75 to 36.76)

0.018

  1. VAP ventilator-associated pneumonia, RT respiratory therapist
  2. * LTVV defined in tidal volume ≤ 8 ml/kg PBW in the second day of ventilation
  3. ** Calculated as the risk difference from a mixed-effect model with the phase of the study as a fixed effect and the hospital as random effect. The comparison is the difference in the use of low tidal volume ventilation among each factor
  4. aComparison of > 324 vs ≤ 324 beds
  5. bComparison of > 21 vs ≤ 21 beds
  6. cComparison of full-time vs. none/half-time