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Table 2 Factor associated with the use of low tidal volume

From: Organizational factors associated with adherence to low tidal volume ventilation: a secondary analysis of the CHECKLIST-ICU database

 All patients (n = 5719)LTVV* (n = 3340)No LTVV* (n = 2379)Absolute difference** (95% CI)p value
Related to the trial
 Use of checklist1279 (22.4)843 (25.2)436 (18.3)4.41 (− 0.20 to 9.02)0.061
Related to the hospital
 Tertiary4605 (81.5)2742 (83.2)1863 (79.1)5.04 (− 2.29 to 12.35)0.180
 Specialty1060 (18.8)691 (21.0)369 (15.7)5.61 (− 2.89 to 14.06)0.197
 University2202 (39.0)1309 (39.7)893 (37.9)− 2.23 (− 8.57 to 4.12)0.493
Number of beds
 < 1571887 (33.4)1086 (32.9)801 (34.0)8.62 (2.08 to 15.17)a0.011
 157–3241906 (33.7)1041 (31.6)865 (36.7)
 > 3241857 (32.9)1169 (35.5)688 (29.2)
Number of ICU beds0.445
 < 112362 (41.8)1364 (41.4)998 (42.4)1.85 (− 5.17 to 8.87)b0.606
 11–211774 (31.4)1028 (31.2)746 (31.7)
 > 211514 (26.8)904 (27.4)610 (25.9)
Related to organization
 Multidisciplinary rounds3444 (60.2)2068 (61.9)1376 (57.8)− 0.15 (− 3.63 to 3.34)0.932
 Sedation protocol2620 (46.4)1509 (45.8)1111 (47.2)− 2.02 (− 8.08 to 4.02)0.514
 Analgesia protocol2285 (40.4)1342 (40.7)943 (40.1)2.18 (− 3.99 to 8.37)0.490
 Weaning protocol3644 (64.5)2090 (63.4)1554 (66.0)− 1.36 (− 7.73 to 5.02)0.677
 VAP protocol3621 (64.1)2046 (62.1)1575 (66.9)− 3.58 (− 9.89 to 2.74)0.269
Board-certified consultant
 None371 (6.6)204 (6.2)167 (7.1)4.11 (− 1.92 to 10.15)c0.185
 Full-time3015 (53.4)1821 (55.2)1194 (50.7)
 Half-time2264 (40.1)1271 (38.6)993 (42.2)
 1:10 physician5466 (96.7)3205 (97.2)2261 (96.0)6.74 (− 8.75 to 22.22)0.395
 Board-certified RT coordinator3920 (69.4)2309 (70.1)1611 (68.4)− 2.69 (− 9.41 to 4.06)0.436
1:10 respiratory therapist
 None108 (1.9)69 (2.1)39 (1.7)− 2.53 (− 8.59 to 3.53)c0.415
 Full-time2438 (43.2)1383 (42.0)1055 (44.8)
 Half-time3104 (54.9)1844 (55.9)1260 (53.5)
 1:10 nurse5482 (97.0)3227 (97.9)2255 (95.8)20.24 (3.75 to 36.76)0.018
  1. VAP ventilator-associated pneumonia, RT respiratory therapist
  2. * LTVV defined in tidal volume ≤ 8 ml/kg PBW in the second day of ventilation
  3. ** Calculated as the risk difference from a mixed-effect model with the phase of the study as a fixed effect and the hospital as random effect. The comparison is the difference in the use of low tidal volume ventilation among each factor
  4. aComparison of > 324 vs ≤ 324 beds
  5. bComparison of > 21 vs ≤ 21 beds
  6. cComparison of full-time vs. none/half-time