TY - JOUR AU - Valade, Sandrine AU - Mariotte, Eric AU - Azoulay, Elie AU - Darmon, Michael PY - 2020 DA - 2020/06/13 TI - High-dose methotrexate in ICU patients: a retrospective study JO - Annals of Intensive Care SP - 81 VL - 10 IS - 1 AB - High-dose methotrexate (HD-MTX) is commonly used in the treatment of solid tumors and hematological malignancies. Severe toxicities are frequent, leading to organ dysfunction and death. Risk–benefit ratio of using HD-MTX in critically ill patients is unknown. This study aims to describe MTX-induced toxicities and to assess outcome in ICU patients. We conducted a retrospective single-center study conducted in a university hospital ICU between January 2002 and December 2018. Consecutive patients treated by HD-MTX were included. SN - 2110-5820 UR - https://doi.org/10.1186/s13613-020-00693-5 DO - 10.1186/s13613-020-00693-5 ID - Valade2020 ER -