From: High-dose methotrexate in ICU patients: a retrospective study
N (%) or median (IQR) | Survivors n = 23 | Non survivors n = 10 | P value |
---|---|---|---|
Demographics | |||
Age (years) | 38 [31–51] | 63.5 [51–69] | 0.013 |
Male gender | 14 (61%) | 10 (100%) | 0.058 |
Comorbidities | |||
HIV infection | 9 (39%) | 3 (12%) | 0.914 |
Hypertension | 2 (8.7%) | 2 (20%) | 0.74 |
Diabetes | 1 (4.3%) | 0 | 1 |
Hematological malignancy | 0.52 | ||
B cell lymphoma | 21 (91%) | 10 (100%) | |
Burkitt lymphoma | 10 | 4 | |
Diffuse large B cell lymphoma | 5 | 4 | |
Primary CNS lymphoma | 4 | 1 | |
Primary effusion lymphoma | 2 | 0 | |
Intravascular lymphoma | 0 | 1 | |
T cell lymphoma | 2 (8.7%) | 0 | |
Reason for ICU admission | 0.575 | ||
Neurological disorders | 10 (43.5%) | 4 (40%) | |
Acute kidney injury | 6 (26%) | 2 (20%) | |
Acute respiratory distress | 3 (13%) | 2 (20%) | |
Cardiovascular failure | 0 | 1 (10%) | |
Other | 4 (17%) | 1 (10%) | |
Biological tests | |||
Creatinine (µmol/L) | 55 [39–72] | 56 [47–86] | 0.26 |
Albumin (g/L) | 36 [31–38] | 27.5 [24–31.8] | 0.045 |
Bilirubin (µmol/L) | 7.8 [6–13.2] | 12 [6.9–13.4] | 0.329 |
Leukocytes (G/L) | 7.7 [5.1–8.9] | 7.1 [1.5–10.0] | 0.78 |
Hemoglobin (g/dL) | 9.7 [8.3–12.5] | 9.0 [8.1–10.3] | 0.32 |
Platelets (G/L) | 195 [150–255] | 166 [111–272] | 0.49 |
SOFA score | 2 [1–5] | 6 [4–9.5] | 0.022 |
Treatments in the ICU | |||
Mechanical ventilation | 10 (43.5%) | 9 (90%) | 0.036 |
Vasopressors | 3 (13%) | 7 (70%) | 0.004 |
Renal replacement therapy | 0 | 3 (30%) | 0.036 |