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Table 1 Characteristics of patients at study inclusion

From: High-dose methotrexate in ICU patients: a retrospective study

N (%) or median (IQR)Survivors
n = 23
Non survivors
n = 10
P value
Demographics
 Age (years)38 [31–51]63.5 [51–69]0.013
 Male gender14 (61%)10 (100%)0.058
Comorbidities
 HIV infection9 (39%)3 (12%)0.914
 Hypertension2 (8.7%)2 (20%)0.74
 Diabetes1 (4.3%)01
Hematological malignancy  0.52
 B cell lymphoma21 (91%)10 (100%) 
  Burkitt lymphoma104 
  Diffuse large B cell lymphoma54 
  Primary CNS lymphoma41 
  Primary effusion lymphoma20 
  Intravascular lymphoma01 
  T cell lymphoma2 (8.7%)0 
Reason for ICU admission  0.575
 Neurological disorders10 (43.5%)4 (40%) 
 Acute kidney injury6 (26%)2 (20%) 
 Acute respiratory distress3 (13%)2 (20%) 
 Cardiovascular failure01 (10%) 
 Other4 (17%)1 (10%) 
Biological tests
 Creatinine (µmol/L)55 [39–72]56 [47–86]0.26
 Albumin (g/L)36 [31–38]27.5 [24–31.8]0.045
 Bilirubin (µmol/L)7.8 [6–13.2]12 [6.9–13.4]0.329
 Leukocytes (G/L)7.7 [5.1–8.9]7.1 [1.5–10.0]0.78
 Hemoglobin (g/dL)9.7 [8.3–12.5]9.0 [8.1–10.3]0.32
 Platelets (G/L)195 [150–255]166 [111–272]0.49
SOFA score2 [1–5]6 [4–9.5]0.022
Treatments in the ICU
 Mechanical ventilation10 (43.5%)9 (90%)0.036
 Vasopressors3 (13%)7 (70%)0.004
 Renal replacement therapy03 (30%)0.036
  1. HIV human immunodeficiency virus, SOFA score Sepsis-related Organ Failure Assessment, ICU intensive care unit