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Table 1 Characteristics of patients at study inclusion

From: High-dose methotrexate in ICU patients: a retrospective study

N (%) or median (IQR)

Survivors

n = 23

Non survivors

n = 10

P value

Demographics

 Age (years)

38 [31–51]

63.5 [51–69]

0.013

 Male gender

14 (61%)

10 (100%)

0.058

Comorbidities

 HIV infection

9 (39%)

3 (12%)

0.914

 Hypertension

2 (8.7%)

2 (20%)

0.74

 Diabetes

1 (4.3%)

0

1

Hematological malignancy

  

0.52

 B cell lymphoma

21 (91%)

10 (100%)

 

  Burkitt lymphoma

10

4

 

  Diffuse large B cell lymphoma

5

4

 

  Primary CNS lymphoma

4

1

 

  Primary effusion lymphoma

2

0

 

  Intravascular lymphoma

0

1

 

  T cell lymphoma

2 (8.7%)

0

 

Reason for ICU admission

  

0.575

 Neurological disorders

10 (43.5%)

4 (40%)

 

 Acute kidney injury

6 (26%)

2 (20%)

 

 Acute respiratory distress

3 (13%)

2 (20%)

 

 Cardiovascular failure

0

1 (10%)

 

 Other

4 (17%)

1 (10%)

 

Biological tests

 Creatinine (µmol/L)

55 [39–72]

56 [47–86]

0.26

 Albumin (g/L)

36 [31–38]

27.5 [24–31.8]

0.045

 Bilirubin (µmol/L)

7.8 [6–13.2]

12 [6.9–13.4]

0.329

 Leukocytes (G/L)

7.7 [5.1–8.9]

7.1 [1.5–10.0]

0.78

 Hemoglobin (g/dL)

9.7 [8.3–12.5]

9.0 [8.1–10.3]

0.32

 Platelets (G/L)

195 [150–255]

166 [111–272]

0.49

SOFA score

2 [1–5]

6 [4–9.5]

0.022

Treatments in the ICU

 Mechanical ventilation

10 (43.5%)

9 (90%)

0.036

 Vasopressors

3 (13%)

7 (70%)

0.004

 Renal replacement therapy

0

3 (30%)

0.036

  1. HIV human immunodeficiency virus, SOFA score Sepsis-related Organ Failure Assessment, ICU intensive care unit