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Table 2 Characteristics of antimicrobial therapy: main molecule used and duration

From: Impact of prior antibiotics on infected pancreatic necrosis microbiology in ICU patients: a retrospective cohort study

  Total patients n = 56 Exposed groupan = 33 Unexposed group n = 23 P value
First line antimicrobial therapy, n (%)
 Penicillin (amoxicillin and Peni M) 6 (11) 2 (6) 4 (17) 0.4
 Amoxicillin–clavulanic acid 10 (18) 4 (12) 6 (26) 0.3
 Piperacillin–tazobactam 16 (29) 9 (27) 7 (30) 1
 Carbapenem 11 (19) 10 (30) 1 (4) 0.08
 Cephalosporin 11 (19) 7 (21) 4 (17) 1
 Fluoroquinolone 1 (2) 1 (3) 0 1
 Cotrimoxazole 1 (2) 0 1 (4) 0.42
 Metronidazole 33 (59) 17 (52) 16 (70) 0.51
 Aminoglycoside 11 (19) 7 (21) 4 (17) 1
 Anti-fungal 6 (11) 4 (12) 2 (9) 1
Time of overall antimicrobial therapy in ICU (median in days [IQR]) 47 [28–77] 50 [28–88] 38.5 [26–61] 0.18
Number of overall different antimicrobial agents in ICU (median [IQR]) 4 [2–6] 5 [4–8] 3 [2–5] 0.002
  1. Italic value indicates significance of P value (P < 0.05)
  2. aExposure was defined as patients who were started on antibiotics more than 24 h before the first pancreatic sample was collected