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Table 2 Baseline characteristics

From: Pharmacokinetics of tigecycline in critically ill patients with liver failure defined by maximal liver function capacity test (LiMAx)

 

Total

Group A

Group B

Group C

pa,b,c

Patients (n)

33

5

21

7

 

Age (year)

63 (54–73)

59 (54–77)

65 (55–73)

59 (54–68)

0.456a

Gender (m/f)

20/13

3/2

14/7

¾

0.812c

BMI (kg/m2)

26.4 (22.6–31.2)

22.5 (18.3–22.7)

27.7 (24.4–31.1)

31.3 (24.5–46.4)

0.018b

WBC (/nL)

17 (13–22)

26 (25–34)

14 (10–21)

15 (11–35)

0.190b

CRP (mmol/L)

124.2 (78.3–217.3)

88.8 (61.1–197.8)

135 (106.9–176.8)

114.3 (42.2–210.8)

0.899a

INR

1.38 (1.24–1.54)

1.28 (1.24–1.54)

1.39 (1.28–1.56)

1.34 (1.19–1.98)

0.584a

Lactate (mg/dL)

15 (12–27)

30 (21–55)

15 (11–21)

15 (13–26)

0.114b

Platelets count (/nL)

182 (104–374)

136 (68–287)

171 (88–310)

335 (187–444)

0.127a

Albumin (g/L)

22.6 (19.6–25.03)

22.9 (16.8–29.2)

22.7 (18–25.4)

24 (16.8–25.2)

0.766a

Creatinine clearance (mL/min)

32 (20–64)

29 (0–75)

32 (21–57)

32 (25–89)

0.606a

SOFA score

9 (5–11)

12 (11–16)

9 (5–11)

8 (4–10)

0.017a

SAPSII score

55 (41–72)

57 (51–65)

59 (39–71)

55 (35–68)

0.547a

APACHE II score

23 (18–30)

27 (21–34)

25 (15–28)

28 (19–30)

0.698a

Duration of therapy (days)

8 (6–12)

7 (4–9)

9 (7–14)

6 (5–12)

0.857b

  1. Data are presented as median and interquartile range (25th to 75th percentile) or frequencies
  2. BMI: body mass index; WBC: white blood cell count; CRP: C-reactive protein; INR: international normalized ratio; SOFA: Sequential Organ Failure Assessment; SAPS: Simplified Acute Physiology Score; APACHE II: Acute Physiology and Chronic Health Evaluation; p value: comparison between group A and D: aIndependent t test, bMann–Whitney U test, cFisher’s exact test