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Table 2 Baseline characteristics

From: Pharmacokinetics of tigecycline in critically ill patients with liver failure defined by maximal liver function capacity test (LiMAx)

  Total Group A Group B Group C pa,b,c
Patients (n) 33 5 21 7  
Age (year) 63 (54–73) 59 (54–77) 65 (55–73) 59 (54–68) 0.456a
Gender (m/f) 20/13 3/2 14/7 ¾ 0.812c
BMI (kg/m2) 26.4 (22.6–31.2) 22.5 (18.3–22.7) 27.7 (24.4–31.1) 31.3 (24.5–46.4) 0.018b
WBC (/nL) 17 (13–22) 26 (25–34) 14 (10–21) 15 (11–35) 0.190b
CRP (mmol/L) 124.2 (78.3–217.3) 88.8 (61.1–197.8) 135 (106.9–176.8) 114.3 (42.2–210.8) 0.899a
INR 1.38 (1.24–1.54) 1.28 (1.24–1.54) 1.39 (1.28–1.56) 1.34 (1.19–1.98) 0.584a
Lactate (mg/dL) 15 (12–27) 30 (21–55) 15 (11–21) 15 (13–26) 0.114b
Platelets count (/nL) 182 (104–374) 136 (68–287) 171 (88–310) 335 (187–444) 0.127a
Albumin (g/L) 22.6 (19.6–25.03) 22.9 (16.8–29.2) 22.7 (18–25.4) 24 (16.8–25.2) 0.766a
Creatinine clearance (mL/min) 32 (20–64) 29 (0–75) 32 (21–57) 32 (25–89) 0.606a
SOFA score 9 (5–11) 12 (11–16) 9 (5–11) 8 (4–10) 0.017a
SAPSII score 55 (41–72) 57 (51–65) 59 (39–71) 55 (35–68) 0.547a
APACHE II score 23 (18–30) 27 (21–34) 25 (15–28) 28 (19–30) 0.698a
Duration of therapy (days) 8 (6–12) 7 (4–9) 9 (7–14) 6 (5–12) 0.857b
  1. Data are presented as median and interquartile range (25th to 75th percentile) or frequencies
  2. BMI: body mass index; WBC: white blood cell count; CRP: C-reactive protein; INR: international normalized ratio; SOFA: Sequential Organ Failure Assessment; SAPS: Simplified Acute Physiology Score; APACHE II: Acute Physiology and Chronic Health Evaluation; p value: comparison between group A and D: aIndependent t test, bMann–Whitney U test, cFisher’s exact test