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Table 1 Baseline, intraoperative and postoperative variables among the treatment groups

From: Impact of the perioperative inotropic support in grown-up congenital heart patients undergoing cardiac surgery: a propensity score adjusted analysis

Variables Levosimendan (n = 94) Milrinone (n = 118) P value
Baseline
 Age (years) 27.49 ± 15.00 32.76 ± 14.89 0.01
 Weight (kg) 60.21 ± 15.26 66.93 ± 17.34 0.003
 Redo-surgery 60 (0.64) 61 (0.52) 0.09
 Euroscore II 4.76 ± 8 76 2.13 ± 1 73 0.005
 NYHA 2.66 ± 0.78 2.3 ± 0.78 < 0.001
 LV ejection fraction (%) 60.47 ± 14.71 64.58 ± 8.66 0.02
 LV hypertrophy 28 (0.30) 13 (0.11) < 0.001
 LV dilatation 9 (0.10) 15 (0.13) 0.52
 RV function altered 22 (0.23) 26 (0.22) 0.007
 RV hypoplastic 7 (0.07) 0 0.29
 RV hypertrophy 5 (0.05) 12 (0.10) 0.05
 RV dilatation 36 (0.42) 67 (0.57) 0.81
 Pulmonary hypertension 8 (0.09) 9 (0.08) 0.06
Year of operation: 2013 11 (0.12) 33 (0.28)  
 2014 20 (0.21) 21 (0.18)  
 2015 20 (0.23) 16 (0.14)  
 2016 27 (0.28) 30 (0.25)  
 2017 16 (0.16) 18 (0.15)  
Intraoperative
 CPB duration (min) 187 ± 87 115 ± 51 < 0.001
 Cross-clamping duration (min) 79 ± 60 54 ± 42 < 0.001
Postoperative
 Number of days on epinephrine 1 [0–2.75] 0 [0–1] 0.03
 VIS on postoperative day 1 10.21 ± 10.52 10.06 ± 11.51 0.92
 VIS on postoperative day 2 6.31 ± 8.48 6.25 ± 9.78 0.96
 VIS on postoperative day 3 3.9 ± 6.87 3.14 ± 9.1 0.50
 VIS on postoperative day 4 2.25 ± 5.38 2.16 ± 9.37 0.93
 CPIS within 48 h of admission 1.64 ± 2.19 1.50 ± 1.83 0.70
 Duration of mechanical ventilation (h) 12 [5.25–34.50] 4 [2–8] < 0.001
 Requiring renal replacement therapy 8 (0.09) 3 (0.03) 0.06
 IABP or ECMO 8 (0.09) 1 (0.01) 0.05
 Duration of intensive care unit stay (days) 4 [3–8] 3 [2–4] < 0.001
 Duration of hospital stay (days) 13 [9–21] 10 [8–13] < 0.001
  1. Data are shown as means ± standard deviations, or as numbers and proportions. All P values were estimated using the Student’s t test, the χ2 or the Fisher test. Statistically significant results are shown in italics
  2. CPB cardiopulmonary bypass, CPIS Clinical Pulmonary Infection Score, ECMO extracorporeal membrane oxygenation, IABP intra-aortic balloon pump therapy, LV left ventricle, NYHA New York Heart Association, RV right ventricle, VIS vasoactive inotropic score