Table 1 Baseline, intraoperative and postoperative variables among the treatment groups
Variables | Levosimendan (n = 94) | Milrinone (n = 118) | P value |
|---|---|---|---|
Baseline | |||
Age (years) | 27.49 ± 15.00 | 32.76 ± 14.89 | 0.01 |
Weight (kg) | 60.21 ± 15.26 | 66.93 ± 17.34 | 0.003 |
Redo-surgery | 60 (0.64) | 61 (0.52) | 0.09 |
Euroscore II | 4.76 ± 8 76 | 2.13 ± 1 73 | 0.005 |
NYHA | 2.66 ± 0.78 | 2.3 ± 0.78 | < 0.001 |
LV ejection fraction (%) | 60.47 ± 14.71 | 64.58 ± 8.66 | 0.02 |
LV hypertrophy | 28 (0.30) | 13 (0.11) | < 0.001 |
LV dilatation | 9 (0.10) | 15 (0.13) | 0.52 |
RV function altered | 22 (0.23) | 26 (0.22) | 0.007 |
RV hypoplastic | 7 (0.07) | 0 | 0.29 |
RV hypertrophy | 5 (0.05) | 12 (0.10) | 0.05 |
RV dilatation | 36 (0.42) | 67 (0.57) | 0.81 |
Pulmonary hypertension | 8 (0.09) | 9 (0.08) | 0.06 |
Year of operation: 2013 | 11 (0.12) | 33 (0.28) | |
2014 | 20 (0.21) | 21 (0.18) | |
2015 | 20 (0.23) | 16 (0.14) | |
2016 | 27 (0.28) | 30 (0.25) | |
2017 | 16 (0.16) | 18 (0.15) | |
Intraoperative | |||
CPB duration (min) | 187 ± 87 | 115 ± 51 | < 0.001 |
Cross-clamping duration (min) | 79 ± 60 | 54 ± 42 | < 0.001 |
Postoperative | |||
Number of days on epinephrine | 1 [0–2.75] | 0 [0–1] | 0.03 |
VIS on postoperative day 1 | 10.21 ± 10.52 | 10.06 ± 11.51 | 0.92 |
VIS on postoperative day 2 | 6.31 ± 8.48 | 6.25 ± 9.78 | 0.96 |
VIS on postoperative day 3 | 3.9 ± 6.87 | 3.14 ± 9.1 | 0.50 |
VIS on postoperative day 4 | 2.25 ± 5.38 | 2.16 ± 9.37 | 0.93 |
CPIS within 48 h of admission | 1.64 ± 2.19 | 1.50 ± 1.83 | 0.70 |
Duration of mechanical ventilation (h) | 12 [5.25–34.50] | 4 [2–8] | < 0.001 |
Requiring renal replacement therapy | 8 (0.09) | 3 (0.03) | 0.06 |
IABP or ECMO | 8 (0.09) | 1 (0.01) | 0.05 |
Duration of intensive care unit stay (days) | 4 [3–8] | 3 [2–4] | < 0.001 |
Duration of hospital stay (days) | 13 [9–21] | 10 [8–13] | < 0.001 |