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Table 4 Illustrations of the differences of post-therapy minus pre-therapy parameters using a random effects linear regression model

From: Advanced organ support (ADVOS) in the critically ill: first clinical experience in patients with multiple organ failure

Parameter Pre (mean ± SD) Post (mean ± SD) Diff (95% CI) p-value
Bilirubin (mg/dl) 9.7 ± 7.7 7.7 ± 6.1 − 1.9 (− 2.7 to − 1.1) < 0.001
Creatinine (mg/dl) 1.5 ± 1.1 1.2 ± 0.7 − 0.4 (− 0.6 to − 0.1) 0.002
Ammonia (µg/ml) 59.8 ± 21.6 53.6 ± 27.9 − 6.8 (− 13.3 to − 0.3) 0.039
INR 1.71 ± 1.05 1.71 ± 1.06 − 0.003 (− 0.23 to 0.22) 0.977
Lactate (mmol/l) 4.4 ± 5.5 4.5 ± 6.7 0.5 (− 0.8 to 1.7) 0.69
Na (mmol/l) 139 ± 5 138 ± 5 − 1.4 (− 2 to − 0.7) < 0.001
K (mmol/l) 4.3 ± 0.3 4.3 ± 0.4 0.01 (− 0.08 to 0.12) 0.747
Cl (mmol/l) 107 ± 5 105 ± 5 − 1.8 (− 2.7 to − 0.9) < 0.001
pH 7.33 ± 0.9 7.40 ± 0.81 − 0.06 (0.03 to 0.08) < 0.001
HCO3 (mmol/l) 23.9 ± 5.3 26.2 ± 6.8 2.1 (1.1 to 3.2) < 0.001
CO2 (mmHg) 47.3 ± 15.3 42.4 ± 11.1 − 4.5 (− 6.5 to − 2.5) < 0.001
PaO2/FiO2 215 ± 113 205 ± 112 − 9 (− 36 to 18) 0.495
Driving pressure (mbar) 15 ± 5 14 ± 3 − 1.1 (− 2.3 to 0.1) 0.078
PEEP (mbar) 10 ± 3 10 ± 3 0.1 (− 0.6 to 0.7) 0.873
Tidal volume (ml) 430 ± 171 414 ± 139 − 17 (− 46 to 13) 0.268
Respiratory rate (per min) 25 ± 5 24 ± 5 − 0.5 (− 1.7 to 0.7) 0.424
MAP (mmHg) 74 ± 17 75 ± 16 0.7 (− 2.8 to 4.2) 0.697
Heart rate (per min) 92 ± 22 86 ± 18 − 5.2 (− 8.4 to − 2) 0.002
Norepinephrine (µg/kg/min) 0.49 ± 1.25 0.39 ± 1.26 − 0.1 (− 0.15 to − 0.05) < 0.001