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Table 1 Demographic characteristics, respiratory mechanics, and hemodynamic parameters, according to respiratory system elastance

From: Is hypoxemia explained by intracardiac or intrapulmonary shunt in COVID-19-related acute respiratory distress syndrome?

Characteristic

All patients

n = 60

Lower Ers

n = 30

Higher Ers

n = 30

P value

Age (y)

62 [51–72]

64 [50–73]

58 [53–69]

0.36

Male gender (%)

50 (83)

27 (90)

23 (77)

0.17

Body mass index (kg/m2)

27 [24–32]

28 [24–32]

27 [25–31]

0.76

PEEP (cmH20)

11 [9–12]

12 [9–12]

10 [8–12]

0.13

Driving pressure (cmH2O)

12 [11–15]

11 [9–12]

14 [13–16]

< 0.001

Crs (mL/cmH2O)

32 [27–40]

40 [36–45]

27 [21–30]

< 0.001

Ers (cmH2O/L)

32 [24–34]

25 [22–28]

38 [33–48]

< 0.001

PaO2/FiO2 (mmHg)

142 [107–194]

170 [131–224]

119 [72–177]

< 0.01

PaCO2 (mmHg)

42 [38–47]

42 [36–46]

44 [40–51]

0.07

LVEF (%)

60 [49–6]

60 [49–68]

60 [48–70]

0.88

Cardiac index (L/min/m2)

2.78 [2.42–3.40]

2.69 [2.39–3.23]

2.95 [2.44–3.71]

0.24

RV/LV area ratio

0.6 [0.50–0.70]

0.6 [0.50–0.73]

0.58 [0.49–0.70]

0.96

Acute cor pulmonale (%)

26 (43)

13 (43)

13 (43)

> 0.99

PFO shunt (%)

6 (10)

2 (7)

4 (13)

0.67

TPBT (%)

12 (20)

8 (27)

4 (13)

0.20

  1. Ers: respiratory system elastance; PEEP: positive end-expiratory pressure; Crs: respiratory system compliance; PaO2/FiO2: ratio of partial pressure of oxygen in arterial blood and fraction of inspired oxygen; PaCO2: partial pressure of carbon dioxide in arterial blood; LVEF: left ventricle ejection fraction; RV: right ventricle; LV: left ventricle; PFO: patent foramen ovale; TPBT: transpulmonary bubble transit
  2. Mann–Whitney test for continuous variables and Chi-square test or Fisher exact test for categorical variables