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Table 1 Clinical and demographic characteristics of the study population (n = 462)

From: Prognostic performance of endothelial biomarkers to early predict clinical deterioration of patients with suspected bacterial infection and sepsis admitted to the emergency department

  Deterioration (n = 124) No deterioration (n = 338) Total (n = 462) p value
Male 70 (56) 182 (54) 252 (55) 0.694a
Age (years) 73 [60–82] 63 [45–78] 66 [48–80]  < .001b
Numbers of comorbidities     0.001a
 0 46 (37) 188 (56) 234 (51)  
 1 38 (31) 84 (25) 122 (26)  
 > 1 40 (32) 66 (20) 106 (23)  
Comorbidities, n (%)
 Cardiovascular disease 31 (25) 36 (11) 67 (15)  < .001a
 Renal disease 11 (9) 9 (3) 20 (4) 0.003a
 Respiratory disease 27 (22) 45 (13) 72 (16) 0.023a
 Diabetes 33 (27) 77 (23) 110 (24) 0.39a
Charlson score 4 [2.75–5] 2 [0–5] 3 [1,2,3,4,5]  < .001b
Diagnostic category at T0     1.000a
 Sepsis 85 (69) 232 (69) 317 (69)  
 Severe sepsis 39 (31) 106 (31) 145 (31)  
SOFA category at inclusion     0.003a
 SOFA < 2 48 (39) 185 (55) 233 (50)  
 SOFA ≥ 2 76 (61) 153 (45) 229 (50)  
Lactates (mmol/L) 1.7 [1.2–2.3] 1.7 [1.2–2.5] 1.7 [1.2–2.4] 0.999b
Lymphocytes (G/L) 0.78 [0.4–1.1] 0.94 [0.6–1.4] 0.9 [0.5–1.3] 0.003b
qSOFA score     0.018c
 0 39 (31) 14 (44) 188 (41)  
 1 81 (65) 185 (55) 266 (58)  
 2 4 (3) 4 (1) 8 (2)  
Site of infection     0.049a
 Pulmonary 46 (37) 89 (26) 135 (29)  
 Urinary 25 (20) 102 (30) 127 (27)  
 Abdominopelvic 34 (27) 83 (25) 117 (25)  
 Others 19 (15) 64 (19) 83 (18)  
Hospitalization after ED discharge     < .001a
 Ward 74 (60) 209 (64) 283 (63)  
 Surgery 21 (17) 87 (27) 108 (24)  
 Stepdown unit 12 (10) 21 (6) 33 (7)  
 ICU 16 (13) 9 (3) 25 (6)  
ATB delay (hours) 3.9 [2.4–7] 4.1 [2.3–6.7] 4.1 [2.3–6.7] 0.675b
LOS (days) 8 [6,7,8,9,10,11,12,13] 5 [3,4,5,6,7] 5 [3,4,5,6,7,8,9] < .001b
D-28 mortality 6 (5) 6 (2) 12 (3) 0.132a
  1. Data are expressed either as n (%) or as median [Q1, Q3]
  2. ATB antibiotherapy, ICU intensive care unit, LOS length of stay
  3. aPearson χ2 test
  4. bWilcoxon–Mann–Whitney
  5. cFisher