Prognostic performance of endothelial biomarkers to early predict clinical deterioration of patients with suspected bacterial infection and sepsis admitted to the emergency department

Annals of Intensive Care

Table 2 Factors predictive of early deterioration using univariate and multivariate analyses in the entire cohort (n = 462) at inclusion (T0)

Variable	Univariate analysis		Multivariate analysis		Predictive performance
Variable	p value	IQR OR [95% CI]	p value	IQR OR [CI]	AUC [CI]	sp	NPV	PPV
Lactates	ns	–	ns	–	0.50 [0.43–0.57]	0.12	0.76	0.29
CRP	ns	–	ns	–	0.55 [0.49–0.61]	0.16	0.81	0.28
qSOFA score	7.89E−03	1.73 [1.16–2.61]	ns	–	0.57 [0.52–0.62]	0.14	0.79	0.28
Lymphocytes	3.00E−03	1.45 [1.19–2.17]	ns	–	0.59 [0.54–0.66]	0.18	0.86	0.28
SOFA score	2.27E−04	1.29 [1.13–1.49]	ns	–	0.61 [0.55–0.66]	0.18	0.83	0.29
Age	9.55E−05	1.25 [1.12–1.40]	ns	–	0.62 [0.57–0.68]	0.21	0.85	0.29
Charlson score	2.43E−05	1.19 [1.10–1.29]	ns	–	0.64 [0.59–0.69]	0.23	0.86	0.3
PCT	1.35E−04	1.11 [1.05–1.17]	1.90E−03	1.10 [1.04–1.17]	0.62 [0.56–0.68]	0.16	0.82	0.28
suPAR	2.28E−08	1.92 [1.53–2.42]	3.16E−03	1.57 [1.21–2.07]	0.66 [0.60–0.72]	0.20	0.84	0.29
sVEGFR2	7.19E−06	2.11 [1.53–2.94]	6.59E−04	1.53 [1.07–2.23]	0.65 [0.60–0.71]	0.25	0.87	0.31
suPAR–sVEGFR2 Combination	1.32E−09	2.14 [1.69–2.76]	4.38E−04	1.78 [1.30–2.47]	0.70 [0.65–0.75]	0.33	0.90	0.33

CRP C-reactive protein, SOFA Sequential Organ Failure Assessment, qSOFA quick SOFA, PCT procalcitonin, IQR interquartile, OR odds ratio, CI confidence interval, Sp specificity calculated for a sensitivity higher than 0.90, NPV negative predictive value, PPV positive predictive value