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Table 2 Factors predictive of early deterioration using univariate and multivariate analyses in the entire cohort (n = 462) at inclusion (T0)

From: Prognostic performance of endothelial biomarkers to early predict clinical deterioration of patients with suspected bacterial infection and sepsis admitted to the emergency department

Variable Univariate analysis Multivariate analysis Predictive performance
p value IQR OR [95% CI] p value IQR OR [CI] AUC [CI] sp NPV PPV
Lactates ns ns 0.50 [0.43–0.57] 0.12 0.76 0.29
CRP ns ns 0.55 [0.49–0.61] 0.16 0.81 0.28
qSOFA score 7.89E−03 1.73 [1.16–2.61] ns 0.57 [0.52–0.62] 0.14 0.79 0.28
Lymphocytes 3.00E−03 1.45 [1.19–2.17] ns 0.59 [0.54–0.66] 0.18 0.86 0.28
SOFA score 2.27E−04 1.29 [1.13–1.49] ns 0.61 [0.55–0.66] 0.18 0.83 0.29
Age 9.55E−05 1.25 [1.12–1.40] ns 0.62 [0.57–0.68] 0.21 0.85 0.29
Charlson score 2.43E−05 1.19 [1.10–1.29] ns 0.64 [0.59–0.69] 0.23 0.86 0.3
PCT 1.35E−04 1.11 [1.05–1.17] 1.90E−03 1.10 [1.04–1.17] 0.62 [0.56–0.68] 0.16 0.82 0.28
suPAR 2.28E−08 1.92 [1.53–2.42] 3.16E−03 1.57 [1.21–2.07] 0.66 [0.60–0.72] 0.20 0.84 0.29
sVEGFR2 7.19E−06 2.11 [1.53–2.94] 6.59E−04 1.53 [1.07–2.23] 0.65 [0.60–0.71] 0.25 0.87 0.31
suPAR–sVEGFR2 Combination 1.32E−09 2.14 [1.69–2.76] 4.38E−04 1.78 [1.30–2.47] 0.70 [0.65–0.75] 0.33 0.90 0.33
  1. CRP C-reactive protein, SOFA Sequential Organ Failure Assessment, qSOFA quick SOFA, PCT procalcitonin, IQR interquartile, OR odds ratio, CI confidence interval, Sp specificity calculated for a sensitivity higher than 0.90, NPV negative predictive value, PPV positive predictive value