Table 1 Baseline characteristics and clinical outcomes of septic shock patients with normal versus abnormal capillary refill time at 2 h from inclusion
CRT normal | CRT abnormal | P | |
|---|---|---|---|
Number of patients | 184 (48.7) | 194 (51.3) | |
Age (years) | 63 [60–80] | 69 [56–77] | 0.0001 |
Sex (female) | 88 (47.8) | 93 (47.9) | 0.9 |
APACHE score | 20 [14–25] | 24 [18–29] | 0.0001 |
SOFA score | 9 [7–11] | 10 [8–13] | 0.0001 |
Charlson index | 3 [1–5] | 3 [1–5] | 0.9 |
Randomization arm | LT: 82 (45) | LT: 92 (48) | 0.5 |
CRT-T: 102 (55) | CRT-T:102 (52) | ||
Sepsis origin | Abdominal 64 (35) | Abdominal: 74 (38) | 0.3 |
Pulmonary 55 (30) | Pulmonary: 52 (27) | ||
Urinary 37 (20) | Urinary: 45 (23) | ||
Other 28 (15) | Other: 23 (12) | ||
MAP (mmHg) | 68 [64–78] | 64 [56–73] | 0.0001 |
CVP (mmHg) | 9 [5–13] | 9 [7–13] | 0.3 |
Fluids administered before ICU admission (ml) | 2000 [1350–2907] | 2000 [1200–2500] | 0.13 |
Fluid responsiveness positive state | 98 (53) | 120 (62) | 0.09 |
Fluid administered in boluses between 0 and 8 h (ml) | 1000 [0–1500] | 1500 [500–2500] | 0.001 |
Fluid balance at 8 h (ml) | 1244 [480–2136] | 1842 [977–2977] | 0.001 |
Norepinephrine dose (mcg/kg/min) | 0.17 [0.1–0.3] | 0.26 [0.14–0.43] | 0.0001 |
Lactate (mmol/L) | 3.3 [2.6–4.4] | 4 [2.9–6.5] | 0.0001 |
CRT (s) | 4 [2–5] | 6 [5–7] | 0.0001 |
ScvO2 (%) | 73 [65–80] | 72 [62–78] | 0.36 |
Delta pCO2(v-a) | 7 [4–10] | 7 [5–10] | 0.3 |
SOFA at 24 h | 7 [4–10] | 10 [6–13] | 0.0001 |
Renal replacement therapy | 27 (15) | 39 (20) | 0.16 |
Mechanical ventilation | 123 (67) | 163 (84) | 0.001 |
ICU length of stay (days) | 6 [3–11] | 6 [2–10] | 0.45 |
28-day mortality | 56 (30) | 89 (46) | 0.002 |