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Table 1 Baseline characteristics and clinical outcomes of septic shock patients with normal versus abnormal capillary refill time at 2 h from inclusion

From: A lactate-targeted resuscitation strategy may be associated with higher mortality in patients with septic shock and normal capillary refill time: a post hoc analysis of the ANDROMEDA-SHOCK study

  CRT normal CRT abnormal P
Number of patients 184 (48.7) 194 (51.3)  
Age (years) 63 [60–80] 69 [56–77] 0.0001
Sex (female) 88 (47.8) 93 (47.9) 0.9
APACHE score 20 [14–25] 24 [18–29] 0.0001
SOFA score 9 [7–11] 10 [8–13] 0.0001
Charlson index 3 [1–5] 3 [1–5] 0.9
Randomization arm LT: 82 (45) LT: 92 (48) 0.5
CRT-T: 102 (55) CRT-T:102 (52)
Sepsis origin Abdominal 64 (35) Abdominal: 74 (38) 0.3
Pulmonary 55 (30) Pulmonary: 52 (27)
Urinary 37 (20) Urinary: 45 (23)
Other 28 (15) Other: 23 (12)
MAP (mmHg) 68 [64–78] 64 [56–73] 0.0001
CVP (mmHg) 9 [5–13] 9 [7–13] 0.3
Fluids administered before ICU admission (ml) 2000 [1350–2907] 2000 [1200–2500] 0.13
Fluid responsiveness positive state 98 (53) 120 (62) 0.09
Fluid administered in boluses between 0 and 8 h (ml) 1000 [0–1500] 1500 [500–2500] 0.001
Fluid balance at 8 h (ml) 1244 [480–2136] 1842 [977–2977] 0.001
Norepinephrine dose (mcg/kg/min) 0.17 [0.1–0.3] 0.26 [0.14–0.43] 0.0001
Lactate (mmol/L) 3.3 [2.6–4.4] 4 [2.9–6.5] 0.0001
CRT (s) 4 [2–5] 6 [5–7] 0.0001
ScvO2 (%) 73 [65–80] 72 [62–78] 0.36
Delta pCO2(v-a) 7 [4–10] 7 [5–10] 0.3
SOFA at 24 h 7 [4–10] 10 [6–13] 0.0001
Renal replacement therapy 27 (15) 39 (20) 0.16
Mechanical ventilation 123 (67) 163 (84) 0.001
ICU length of stay (days) 6 [3–11] 6 [2–10] 0.45
28-day mortality 56 (30) 89 (46) 0.002
  1. Data are presented as median [IQR 25–75] or count (percentage)
  2. Data at 8 and 24 h are reported for clarification purposes
  3. APACHE II Acute Physiology And Chronic Health Evaluation II, SOFA Sequential organ failure Assessment score, LT lactate-targeted group, CRT-T CRT targeted group, ICU intensive care unit, MAP mean arterial pressure, CVP central venous pressure, CRT capillary refill time, ScvO2 central venous oxygen saturation, Delta pCO2(v-a) difference between central venous carbon dioxide pressure and arterial carbon dioxide pressure