|
Number of patients
|
184 (48.7)
|
194 (51.3)
| |
|
Age (years)
|
63 [60–80]
|
69 [56–77]
|
0.0001
|
|
Sex (female)
|
88 (47.8)
|
93 (47.9)
|
0.9
|
|
APACHE score
|
20 [14–25]
|
24 [18–29]
|
0.0001
|
|
SOFA score
|
9 [7–11]
|
10 [8–13]
|
0.0001
|
|
Charlson index
|
3 [1–5]
|
3 [1–5]
|
0.9
|
|
Randomization arm
|
LT: 82 (45)
|
LT: 92 (48)
|
0.5
|
|
CRT-T: 102 (55)
|
CRT-T:102 (52)
|
|
Sepsis origin
|
Abdominal 64 (35)
|
Abdominal: 74 (38)
|
0.3
|
|
Pulmonary 55 (30)
|
Pulmonary: 52 (27)
|
|
Urinary 37 (20)
|
Urinary: 45 (23)
|
|
Other 28 (15)
|
Other: 23 (12)
|
|
MAP (mmHg)
|
68 [64–78]
|
64 [56–73]
|
0.0001
|
|
CVP (mmHg)
|
9 [5–13]
|
9 [7–13]
|
0.3
|
|
Fluids administered before ICU admission (ml)
|
2000 [1350–2907]
|
2000 [1200–2500]
|
0.13
|
|
Fluid responsiveness positive state
|
98 (53)
|
120 (62)
|
0.09
|
|
Fluid administered in boluses between 0 and 8 h (ml)
|
1000 [0–1500]
|
1500 [500–2500]
|
0.001
|
|
Fluid balance at 8 h (ml)
|
1244 [480–2136]
|
1842 [977–2977]
|
0.001
|
|
Norepinephrine dose (mcg/kg/min)
|
0.17 [0.1–0.3]
|
0.26 [0.14–0.43]
|
0.0001
|
|
Lactate (mmol/L)
|
3.3 [2.6–4.4]
|
4 [2.9–6.5]
|
0.0001
|
|
CRT (s)
|
4 [2–5]
|
6 [5–7]
|
0.0001
|
|
ScvO2 (%)
|
73 [65–80]
|
72 [62–78]
|
0.36
|
|
Delta pCO2(v-a)
|
7 [4–10]
|
7 [5–10]
|
0.3
|
|
SOFA at 24 h
|
7 [4–10]
|
10 [6–13]
|
0.0001
|
|
Renal replacement therapy
|
27 (15)
|
39 (20)
|
0.16
|
|
Mechanical ventilation
|
123 (67)
|
163 (84)
|
0.001
|
|
ICU length of stay (days)
|
6 [3–11]
|
6 [2–10]
|
0.45
|
|
28-day mortality
|
56 (30)
|
89 (46)
|
0.002
|
