TY - JOUR AU - Nierhaus, Axel AU - Berlot, Giorgio AU - Kindgen-Milles, Detlef AU - Müller, Eckhard AU - Girardis, Massimo PY - 2020 DA - 2020/10/07 TI - Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis JO - Annals of Intensive Care SP - 132 VL - 10 IS - 1 AB - Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Despite treatment being in line with current guidelines, mortality remains high in those with septic shock. Intravenous immunoglobulins represent a promising therapy to modulate both the pro- and anti-inflammatory processes and can contribute to the elimination of pathogens. In this context, there is evidence of the benefits of immunoglobulin M (IgM)- and immunoglobulin A (IgA)-enriched immunoglobulin therapy for sepsis. This manuscript aims to summarize current relevant data to provide expert opinions on best practice for the use of an IgM- and IgA-enriched immunoglobulin (Pentaglobin) in adult patients with sepsis. SN - 2110-5820 UR - https://doi.org/10.1186/s13613-020-00740-1 DO - 10.1186/s13613-020-00740-1 ID - Nierhaus2020 ER -