From: Transpulmonary pressures in obese and non-obese COVID-19 ARDS
VPariable | BMI group | PEEP (cm H2O) | |||||||
---|---|---|---|---|---|---|---|---|---|
6 | 8 | 10 | 12 | 14 | 16 | 18 | 20 | ||
Pplat (cm H2O) | Non-obese$ | 15 [13.6–17.7] | 16.3 [16.2–18.4] | 18 [17.7–21.1] | 21.8 [21.1–22.6] | 25.8 [23.8–25.9] | 29.9 [28.6–30.7] | 34 [32.6–35.4] | 38 [35.4–40.9] |
Obese$ | 16.5 [15.1–17.3] | 17.5 [16.5–18.5] | 20.5 [19–21] | 22.5 [21–23.3] | 24.5 [23.8–26.3] | 27 [25.8–28.5] | 29.5 [27–30.5]* | 31.5 [28.8–32.8]* | |
Total PEEP (cm H2O) | Non-obese$ | 6.8 [6.8–6.9] | 9 [8.4–9.5] | 10.9 [10.9–11] | 12.2 [12.2–13.3] | 15 [15–15] | 16.3 [16.3–16.7] | 19 [19–19] | 20.4 [20.4–21.4] |
Obese$ | 6.9 [6.7–6.9] | 8.7 [8.3–8.9] | 10.5 [10–11] | 13 [12.2–13] | 15 [14–15] | 16.7 [16–17] | 18.5 [18–19] | 20 [20–20.6] | |
∆PRS (cm H2O) | Non-obese$ | 8.2 [6.8–10.2] | 6.8 [6.8–8.9] | 7 [6.8–9.6] | 8.2 [8.2–10.5] | 10.8 [8.8–11.4] | 13.6 [11.6–14.5] | 15 [13.6–16.9] | 18 [14.3–20.2] |
Obese | 9.6 [7.6–10.5] | 8.15 [7.7–9.9] | 10 [8–11] | 9 [8–12] | 10 [8.8–12.3] | 11 [8.8–12.3] | 10.5 [8.1–12.5]* | 11.5 [8–13.3]* | |
Pes. insp (cm H2O) | Non-obese$ | 8.6 [6.9–10.2] | 9.4 [7.6–10.9] | 10 [7.6–11.6] | 10.9 [8.8–11.6] | 10.9 [8.8–12.8] | 10.9 [9.3–12.8] | 12 [9.5–12.9] | 13 [10.9–14.3] |
Obese$ | 11.5 [9.1–14.5] | 11.5 [9.5–15.3] | 11.5 [9.5–16.3] | 12 [9.5–16] | 12.5 [10.5–16.3] | 12.5 [10.6–16.5] | 13 [11.4–17.3] | 13.5 [12.8–17.5] | |
Pes. exp (cm H2O) | Non-obese$ | 7.1 [5.2–8.9] | 7.5 [5.9–8.9] | 7.8 [6.4–10.2] | 8.3 [7.1–10.2] | 9.1 [7.1–10.9] | 9.5 [7.6–11] | 10 [8.1–11.6] | 11 [8.8–12.2] |
Obese$ | 9.9 [8.1–12.3] | 10.5 [8.2–13] | 10.5 [8.5–13.3] | 11 [8.7–14] | 11 [8.7–15] | 11.5 [9.3–14.5] | 11.5 [10.3–15.3] | 12.5 [11–16] | |
PL. insp (cm H2O) | Non-obese$ | 6.8 [6.4–9.3] | 8.2 [6.8–10.3] | 9.6 [9.5–11.5] | 10.9 [10.9–15] | 14.9 [12.9–16.4] | 20.4 [17.7–20.7] | 24.5 [21.1–24.8] | 28 [23.1–28.3] |
Obese$ | 5.5 [2.8–9] | 7 [4.3–9.3] | 9 [6.5–11.3] | 10 [8.5–12.4] | 12.6 [9.5–15] | 14.8 [12.3–17] | 16.2 [13–18.5]* | 17.15 [14.8–19]* | |
PL, ER (cm H2O) | Non-obese$ | 10.8 [9.4–15.4] | 11.9 [10.6–14.3] | 15.4 [14.1–17.3] | 17.6 [15.9–19.2] | 20.5 [18.5–22.1] | 25.7 [23.3–27.7] | 31.1 [26–32.4] | 33.8 [28.6–37.4] |
Obese$ | 13 [11.8–14.2] | 13.8 [12.8–15.7] | 17.2 [14.5–19.1] | 18.4 [15.7–20.9] | 21.7 [18.3–22.8] | 24 [20.3–25.9] | 25.3 [21.3–27.4] | 27.8 [23.8–29.4] | |
PL. exp (cm H2O) | Non-obese$ | 0 [− 1.9 to 1.7] | 1.4 [− 0.2 to 3.4] | 3.2 [1.4–4.6] | 4.1 [2.7–5.4] | 5.9 [4.2–7.4] | 7.3 [5.5–8.6] | 9 [7.5–10.4] | 10 [8.9–11.5] |
Obese$ | − 3.1 [− 5.4 to − 1.3] | − 1.9 [− 4.2 to 0.5] | 0 [− 3 to 1.8] | 1 [− 1 to 3.8] | 3.9 [− 0.3 to 5.8] | 5 [1.8–7] | 7 [3.5–7.6] | 7 [4.8–9]* | |
∆PL | Non-obese$ | 5.5 [4.8–8.9] | 5.4 [4.6–6.8] | 6 [5.4–7.8] | 6.9 [6.2–8.8] | 9.1 [6.8–9.4] | 12 [9.5–13] | 13.7 [10.9–15.5] | 16 [11.5–18.5] |
Obese | 7.6 [5.9–8.7] | 6.7 [5.9–8.2] | 8 [6.5–10] | 7.5 [5.8–10.3] | 9 [6.8–10.4] | 9.4 [7.5–11.3] | 9 [6.6–11.3] | 10.5 [6.8–11.3]* | |
ELRS (cm H2O.L−1) | Non-obese$ | 20 [17.4–23.8] | 18.3 [15.6–23.2] | 18.3 [17–23.3] | 24.1 [18.4–26.4] | 24 [22.7–28.9] | 33.3 [27.4–38.3] | 39.3 [32–43] | 47.1 [33.5–54.1] |
Obese | 27.3 [18.5–38.1] | 26.3 [18–38.3] | 25.1 [17.6–53.7] | 26.7 [18–49.1] | 30.1 [18.6–48.5] | 31.4 [19.9–53.4] | 29.2 [23.3–45.9] | 31.4 [22.9–45.9] | |
ELCW (cm H2O.L−1) | Non-obese | 4.6 [3.8–5.7] | 5.8 [4.7–6.2] | 3.2 [3.1–5.2] | 5.2 [3.5–6.3] | 5.2 [3.6–6.3] | 5.2 [3.6–6.3] | 3.8 [3.2–6.2] | 6.2 [4.7–6.3] |
Obese | 4.2 [4–5.7] | 4.2 [3.5–7.1] | 4.8 [2.7–7.8] | 4.9 [2.7–8.2] | 4.8 [4.2–8.4] | 5.7 [2.7–8.2] | 4.2 [3.5–6.7] | 3.9 [2.7–6.7] | |
ELL(cm H2O.L−1) | Non-obese$ | 15.9 [11.6–20.7] | 13.1 [10.9–17.8] | 15.7 [13.7–19.6] | 20.3 [13.8–22.2] | 20.9 [17.7–24.6] | 30.2 [22.5–33.8] | 36.4 [25.7–39.8] | 41.9 [27.2–48.7] |
Obese | 23.3 [14.6–32.4] | 22.3 [15.3–30.7] | 22.6 [14.9–42] | 23.2 [12.8–39.8] | 26.4 [14.2–42.5] | 28.9 [16.1–43.6] | 25.2 [19.9–36.6] | 28.9 [20.3–38.8] | |
EL ratio | Non-obese$ | 0.79 [0.67–0.87] | 0.75 [0.66–0.80] | 0.8 [0.79–0.84] | 0.81 [0.74–0.84] | 0.83 [0.74–0.85] | 0.86 [0.8–0.9] | 0.9 [0.79–0.92] | 0.89 [0.81–0.9] |
Obese$ | 0.8 [0.77–0.85] | 0.80 [0.78– 0.85] | 0.84 [0.74–0.89] | 0.82 [0.72–0.89] | 0.85 [0.77–0.86] | 0.87 [0.79–0.9] | 0.85 [0.8–0.9] | 0.88 [0.79–0.91] |