Table 4 Univariate and multivariate logistic regression and Cox proportional hazard regression analyses of the treatments and the REDS score of patients who had a blood pressure measured after a minimum 2000 ml of intravenous fluids
From: Treatment variables associated with outcome in emergency department patients with suspected sepsis
Treatment variable | All N = 503 median (IQR) | Survivors N = 419 median (IQR) | Non-survivors N = 84 median (IQR) | Univariate analysis | OR (95% CI) on MVLR | Significance of OR on MVLR | Cox proportional hazard ratio (95% CI) | Significance of Cox proportional hazard ratio |
|---|---|---|---|---|---|---|---|---|
Time to antibiotics (mins) | 39 (24–62) | 39 (24–62) | 38.5 (22–67.5) | p = 0.71 | 1.00 (0.99–1.01) | p = 0.25 | 1.00 (0.99–1.01) | p = 0.28 |
Volume of IVF (ml) | 2000 (2000–3000) | 2000 (2000–3000) | 2625 (2000–3000) | p = 0.0003a | 1.00 (0.99–1.00) | p = 0.77 | 1.00 (0.99–1.00) | p = 0.64 |
MAP mmHg post 2 l fluid bolus | 77 (66–90) | 78 (68–90) | 69 (60–88) | p = 0.0008a | 1.03 (1.00–1.05) | p = 0.02a | 1.03 (1.00–1.05) | p = 0.02a |
Final MAP (mmHg) | 79 (69–89) | 80 (71–89) | 70.5 (60–82.5) | p < 0.0001a | 0.99 (0.96–1.02) | p = 0.5 | 0.99 (0.97–1.02) | p = 0.5 |
Urea (mmol/l) | 7.7(4.8–13.8) | 7(4.5–11.7) | 15.5(9–26) | p < 0.0001a | 1.05 (1.03–1.08) | p < 0.0001a | 1.03 (1.01–1.04) | p = 0.003a |
REDS score | 4 (2–6) | 3 (2–5) | 6 (5–8) | p < 0.0001a | 1.63 (1.42–1.87) | p < 0.0001a | 1.43 (1.29–1.58) | p < 0.0001a |