Impact of systematic screening for AmpC-hyperproducing Enterobacterales intestinal carriage in intensive care unit patients

Annals of Intensive Care

Table 3 Performance of screening for ESBL-E, HLAC-E and 3GCR-E (ESBL-E and/or HLAC-E) intestinal carriage as predictor of their absence/presence in respiratory samples

	Intestinal carriage screening ESBL-E (+)	Intestinal carriage screening HLAC-E (+)	Intestinal carriage screening 3GCR-E (+)
Sensitivity (%) [95% CI]	79.4% [76.5–82.3%]	50.0% [46.5–53.5%]	69.5% [66.2–72.8]
Specificity (%) [95% CI]	78.8% [75.9–81.7%]	92.5% [87.7–97.4%]	71.4% [68.1–74.7]
PPV (%) [95% CI]	14.8% [14.1–15.6%]	20.3% [19.3–21.3%]	16.9% [15.6–18.2]
NPV (%) [95% CI]	98.8% [98–99.6%]	98.0% [97.0–99.0%]	96.6% [95.3–97.8]
Positive LR [95% CI]	3.7 [2.4–5.1]	6.7 [4.9-8.5]	2.4 [1.3–3.5]
Negative LR [95% CI]	0.3 [0.0–0.6]	0.5 [0.0–1.1]	0.4 [0–0.9]

LR: likelihood ratio. Sensitivity, specificity, positive predictive value, negative predictive values are expressed as percentage [95% CI]. Likelihood ratios are expressed as absolute value [95% CI]. ESBL-E, Extended-spectrum beta-lactamase producing Enterobacterales; HLAC-E, high-level expressed AmpC cephalosporinase-producing Enterobacterales; 3GCR-E, 3rd generation cephalosporins resistant Enterobacterales