Skip to main content
Annals of Intensive Care

Table 2 Antifungal treatment in critically ill patients with laboratory-confirmed bloodstream infection with Candida spp. Continuous variables are given as median (1st to 3rd quantile), categorical variables are given as n (%)

From: Epidemiology, clinical characteristics, and outcome of candidemia in critically ill patients in Germany: a single-center retrospective 10-year analysis

 

Study participants n = 391

Non-survivors n = 234

Survivors n = 157

Descriptive p-value (unadjusted)a

Antifungal strategy

   

0.128

 Targeted b

174 (44.5%)

96 (41.0%)

78 (49.7%)

 

 Empirical c

88 (22.5%)

53 (22.6%)

35 (22.3%)

 

 Resistant d

8 (2.0%)

3 (1.3%)

5 (3.2%)

 

 Delayed e

14 (3.6%)

8 (3.4%)

6 (3.8%)

 

 None

107 (27.4%)

74 (31.6%)

33 (21.0%)

 

Treatment with echinocandin

187 (47.8%)

108 (46.2%)

79 (50.3%)

0.419

Empirical therapy c

   

0.435

 Echinocandin

41 (10.5%)

24 (10.3%)

17 (10.8%)

 

 Azoles

48 (12.3%)

32 (13.7%)

16 (10.2%)

 

 Amphotericin B

6 (1.5%)

2 (0.9%)

4 (2.5%)

 

Duration of antifungal treatment (days)

8 (0–17)

5 (0–15)

11 (3–19)

 < 0.001

Antifungals f

 Fluconazole

159 (40.7)

83 (35.5)

76 (48.4)

 

 Anidulafungin

129 (33.0)

75 (32.1)

54 (34.4)

 

 Caspofungin

66 (16.9)

37 (15.8)

29 (18.5)

 

 Voriconazole

22 (5.6)

18 (7.7)

4 (2.5)

 

 Amphotericin B

16 (4.1)

8 (3.4)

8 (5.1)

 

 Posaconazole

1 (0.3)

1 (0.4)

0 (0)

 

 Itraconazole

1 (0.3)

1 (0.4)

0 (0)

 
  1. aWilcoxon–Mann–Whitney U test was performed for continuous variables and Fisher’s exact test for categorical variables. bTargeted treatment was initiated within 24 h of culture positivity. cEmpirical treatment was administered in patients with risk factors for candidemia and persistent fever despite antibacterial medication or positive culture from non-sterile sites. Empirical treatment refers to antifungal medication that was effective according to antifungal susceptibility testing. dResistant: antifungal treatment that was not effective against the detected Candida species. eDelayed: antifungal treatment was started more than 24 h after culture positivity. fAntifungal substances used throughout the study period between 2008 and 2017. The total number does not add up to 284 because of escalation/de-escalation of antifungal treatment
Back to article page