From: Sepsis and septic shock in France: incidences, outcomes and costs of care
Sepsis Implicit definition ICD 10th or CCAM | All | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | Trendsa |
---|---|---|---|---|---|---|---|---|
Cases | 737,147 | 105,733 | 116,139 | 123,792 | 123,950 | 133,651 | 133,882 | |
Incidence per 100.000 (age-standardized) | 206 | 223 | 234 | 231 | 246 | 243 | ↗ | |
Deaths per 100.000 (age-standardized) | 70 | 75 | 79 | 78 | 84 | 86 | ↗ | |
Case fatality (age standardized) | 34 | 33 | 33 | 34 | 34 | 35 | = | |
Hospital stay characteristics | ||||||||
Services of admission | ||||||||
Intensive care unit | 388,057 (52.6) | 56,314 (53.3) | 60,150 (51.8) | 63,662 (51.4) | 64,436 (52) | 70,743 (52.9) | 72,752 (54.3) | ↗ |
Intermediate care facilities | 198,626 (26.9) | 24,112 (22.8) | 28,671 (24.7) | 32,556 (26.3) | 34,917 (28.2) | 38,780 (29) | 39,590 (29.6) | ↗ |
Characteristics of the patients | ||||||||
Baseline characteristics | ||||||||
Age in years, median (IQR) | 71 [59; 81] | 70 [58; 80] | 71 [58; 80] | 71 [59; 81] | 71 [59; 81] | 71 [60; 81] | 71 [60; 81] | ↗ |
Gender (female) | 287,652 (39) | 41,353 (39.1) | 45,511 (39.2) | 48,465 (39.2) | 48,144 (38.8) | 52,033 (38.9) | 52,146 (38.9) | = |
Comorbidities | ||||||||
Myocardial infarction | 134,179 (18.2) | 19,209 (18.2) | 20,933 (18) | 22,639 (18.3) | 22,539 (18.2) | 24,538 (18.4) | 24,321 (18.2) | = |
Congestive heart failure | 222,310 (30.2) | 30,211 (28.6) | 33,946 (29.2) | 37,440 (30.2) | 37,837 (30.5) | 41,556 (31.1) | 41,320 (30.9) | ↗ |
Dementia | 36,808 (5) | 5209 (4.9) | 5943 (5.1) | 6416 (5.2) | 6071 (4.9) | 6722 (5) | 6447 (4.8) | ↘ |
Chronic pulmonary disease | 135,443 (18.4) | 18,608 (17.6) | 20,608 (17.7) | 22,724 (18.4) | 22,514 (18.2) | 25,356 (19) | 25,633 (19.1) | ↗ |
Diabetes without chronic complication | 127,251 (17.3) | 17,831 (16.9) | 19,051 (16.4) | 21,231 (17.2) | 21,563 (17.4) | 24,185 (18.1) | 23,390 (17.5) | ↗ |
Diabetes with chronic complications | 73,562 (10) | 11,029 (10.4) | 11,591 (10) | 12,682 (10.2) | 11,938 (9.6) | 13,432 (10.1) | 12,890 (9.6) | ↘ |
Renal disease | 105,153 (14.3) | 12,925 (12.2) | 15,158 (13.1) | 17,544 (14.2) | 18,002 (14.5) | 20,969 (15.7) | 20,555 (15.4) | ↗ |
Any malignancy | 161,307 (21.9) | 22,040 (20.8) | 24,530 (21.1) | 26,863 (21.7) | 27,548 (22.2) | 30,434 (22.8) | 29,892 (22.3) | ↗ |
Moderate or severe liver disease | 56,528 (7.7) | 8224 (7.8) | 9061 (7.8) | 9643 (7.8) | 9735 (7.9) | 10,132 (7.6) | 9733 (7.3) | ↘ |
Metastatic solid tumor | 52,933 (7.2) | 6420 (6.1) | 7616 (6.6) | 8558 (6.9) | 9128 (7.4) | 10,555 (7.9) | 10,656 (8) | ↗ |
Charlson score, median (IQR) | 2 [1; 4] | 2 [1; 4] | 2 [1; 4] | 2 [1; 4] | 2 [1; 4] | 2 [1; 5] | 2 [1; 5] | ↗ |
Illness severity | ||||||||
Cardio-vascular organ failure | 514,797 (69.8) | 70,002 (66.2) | 79,693 (68.6) | 85,081 (68.7) | 86,258 (69.6) | 95,238 (71.3) | 98,525 (73.6) | ↗ |
Neurological organ failure | 184,188 (25) | 22,442 (21.2) | 26,932 (23.2) | 30,623 (24.7) | 31,451 (25.4) | 35,160 (26.3) | 37,580 (28.1) | ↗ |
Renal organ failure | 294,273 (39.9) | 40,331 (38.1) | 44,465 (38.3) | 48,585 (39.2) | 50,323 (40.6) | 54,827 (41) | 55,742 (41.6) | ↗ |
Respiratory organ failure | 297,664 (40.4) | 42,835 (40.5) | 46,876 (40.4) | 49,722 (40.2) | 50,134 (40.4) | 53,558 (40.1) | 54,539 (40.7) | = |
Number of organ failure, median (IQR) | 3 [2; 4] | 3 [2; 4] | 3 [2; 4] | 3 [2; 4] | 3 [2; 4] | 3 [2; 4] | 3 [2; 4] | ↗ |
SAPS II score, median (IQR) (miss = 241,497¤) | 48 [35; 64] | 48 [35; 64] | 48 [35; 64] | 48 [35; 64] | 48 [35; 64] | 48 [35; 64] | 49 [36; 65] | ↗ |
Outcomes | ||||||||
Hospital LOS(days) (median [IQR]) | 17 [7; 34] | 17 [7; 35] | 17 [7; 34] | 17 [7; 34] | 17 [7; 34] | 17 [8; 34] | 17 [7; 33] | ↘ |
ICU LOS(days) (median [IQR]) (missing = 332,463) | 8 [3; 17] | 8 [3; 19] | 8 [3; 18] | 8 [3; 17] | 8 [3; 17] | 7 [3; 17] | 7 [3; 16] | ↘ |
Discharge to home | 391,409 (53.1) | 55,590 (52.6) | 62,161 (53.5) | 66,413 (53.6) | 66,035 (53.3) | 71,825 (53.7) | 69,385 (51.8) | ↘ |
Hospital mortality | 254,013 (34.5) | 36,206 (34.2) | 39,505 (34) | 42,111 (34) | 42,415 (34.2) | 45,797 (34.3) | 47,979 (35.8) | ↗ |
Cost (€), median (IQR) | 11,400 [5037; 24363] | 11,705.9 [5088; 25364] | 10,991.2 [4778; 24209] | 10,856.1 [4789; 23810] | 11,314 [4938; 24378] | 11,648.3 [5164; 24362] | 11,847.3 [5218; 24192] | = |