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Table 1 Main characteristics of the included sepsis hospital stays in France between 2010 and 2015 and their associated temporal trends

From: Sepsis and septic shock in France: incidences, outcomes and costs of care

Sepsis

Implicit definition ICD 10th or CCAM

All

2010

2011

2012

2013

2014

2015

Trendsa

Cases

737,147

105,733

116,139

123,792

123,950

133,651

133,882

 

Incidence per 100.000 (age-standardized)

 

206

223

234

231

246

243

Deaths per 100.000 (age-standardized)

 

70

75

79

78

84

86

Case fatality (age standardized)

 

34

33

33

34

34

35

 = 

Hospital stay characteristics

        

Services of admission

    

 Intensive care unit

388,057 (52.6)

56,314 (53.3)

60,150 (51.8)

63,662 (51.4)

64,436 (52)

70,743 (52.9)

72,752 (54.3)

 Intermediate care facilities

198,626 (26.9)

24,112 (22.8)

28,671 (24.7)

32,556 (26.3)

34,917 (28.2)

38,780 (29)

39,590 (29.6)

Characteristics of the patients

    

Baseline characteristics

    

 Age in years, median (IQR)

71 [59; 81]

70 [58; 80]

71 [58; 80]

71 [59; 81]

71 [59; 81]

71 [60; 81]

71 [60; 81]

 Gender (female)

287,652 (39)

41,353 (39.1)

45,511 (39.2)

48,465 (39.2)

48,144 (38.8)

52,033 (38.9)

52,146 (38.9)

 = 

Comorbidities

    

 Myocardial infarction

134,179 (18.2)

19,209 (18.2)

20,933 (18)

22,639 (18.3)

22,539 (18.2)

24,538 (18.4)

24,321 (18.2)

 = 

 Congestive heart failure

222,310 (30.2)

30,211 (28.6)

33,946 (29.2)

37,440 (30.2)

37,837 (30.5)

41,556 (31.1)

41,320 (30.9)

 Dementia

36,808 (5)

5209 (4.9)

5943 (5.1)

6416 (5.2)

6071 (4.9)

6722 (5)

6447 (4.8)

 Chronic pulmonary disease

135,443 (18.4)

18,608 (17.6)

20,608 (17.7)

22,724 (18.4)

22,514 (18.2)

25,356 (19)

25,633 (19.1)

 Diabetes without chronic complication

127,251 (17.3)

17,831 (16.9)

19,051 (16.4)

21,231 (17.2)

21,563 (17.4)

24,185 (18.1)

23,390 (17.5)

 Diabetes with chronic complications

73,562 (10)

11,029 (10.4)

11,591 (10)

12,682 (10.2)

11,938 (9.6)

13,432 (10.1)

12,890 (9.6)

 Renal disease

105,153 (14.3)

12,925 (12.2)

15,158 (13.1)

17,544 (14.2)

18,002 (14.5)

20,969 (15.7)

20,555 (15.4)

 Any malignancy

161,307 (21.9)

22,040 (20.8)

24,530 (21.1)

26,863 (21.7)

27,548 (22.2)

30,434 (22.8)

29,892 (22.3)

 Moderate or severe liver disease

56,528 (7.7)

8224 (7.8)

9061 (7.8)

9643 (7.8)

9735 (7.9)

10,132 (7.6)

9733 (7.3)

 Metastatic solid tumor

52,933 (7.2)

6420 (6.1)

7616 (6.6)

8558 (6.9)

9128 (7.4)

10,555 (7.9)

10,656 (8)

 Charlson score, median (IQR)

2 [1; 4]

2 [1; 4]

2 [1; 4]

2 [1; 4]

2 [1; 4]

2 [1; 5]

2 [1; 5]

Illness severity

    

 Cardio-vascular organ failure

514,797 (69.8)

70,002 (66.2)

79,693 (68.6)

85,081 (68.7)

86,258 (69.6)

95,238 (71.3)

98,525 (73.6)

 Neurological organ failure

184,188 (25)

22,442 (21.2)

26,932 (23.2)

30,623 (24.7)

31,451 (25.4)

35,160 (26.3)

37,580 (28.1)

 Renal organ failure

294,273 (39.9)

40,331 (38.1)

44,465 (38.3)

48,585 (39.2)

50,323 (40.6)

54,827 (41)

55,742 (41.6)

 Respiratory organ failure

297,664 (40.4)

42,835 (40.5)

46,876 (40.4)

49,722 (40.2)

50,134 (40.4)

53,558 (40.1)

54,539 (40.7)

 = 

 Number of organ failure, median (IQR)

3 [2; 4]

3 [2; 4]

3 [2; 4]

3 [2; 4]

3 [2; 4]

3 [2; 4]

3 [2; 4]

 SAPS II score, median (IQR) (miss = 241,497¤)

48 [35; 64]

48 [35; 64]

48 [35; 64]

48 [35; 64]

48 [35; 64]

48 [35; 64]

49 [36; 65]

Outcomes

    

 Hospital LOS(days) (median [IQR])

17 [7; 34]

17 [7; 35]

17 [7; 34]

17 [7; 34]

17 [7; 34]

17 [8; 34]

17 [7; 33]

 ICU LOS(days) (median [IQR]) (missing = 332,463)

8 [3; 17]

8 [3; 19]

8 [3; 18]

8 [3; 17]

8 [3; 17]

7 [3; 17]

7 [3; 16]

 Discharge to home

391,409 (53.1)

55,590 (52.6)

62,161 (53.5)

66,413 (53.6)

66,035 (53.3)

71,825 (53.7)

69,385 (51.8)

 Hospital mortality

254,013 (34.5)

36,206 (34.2)

39,505 (34)

42,111 (34)

42,415 (34.2)

45,797 (34.3)

47,979 (35.8)

 Cost (€), median (IQR)

11,400

[5037; 24363]

11,705.9

[5088; 25364]

10,991.2

[4778; 24209]

10,856.1

[4789; 23810]

11,314

[4938; 24378]

11,648.3

[5164; 24362]

11,847.3

[5218; 24192]

 = 

  1. aTest of trend or linear regression for values from 2010 to 2015; a significant increase is observed with a p value < 0.05; a significant decrease is observed with a p value < 0.05; ‘ = ’ no significant trend is observed; ¤ Missing values of 241,497 because SAPS II score was only recorded in case of ICU stay; SAPS II: Simplified Acute Physiology Score II; LOS: length of stay; ICU: intensive care unit