Table 2 Main characteristics of the included septic shock hospital stays in France between 2010 and 2015 and their associated temporal trends

Cases

492,902

69,466

76,350

81,107

81,886

89,934

94,159

Incidence per 100.000 (age-standardized)

135

146

153

152

165

171

↗

Deaths per 100.000 (age-standardized)

62

67

69

69

73

75

↗

Case fatality (age standardized)

46

45

45

45

44

44

↘

Hospital stay characteristics

Services of admission

 Intensive care unit

353,190 (71.7)

50,369 (72.5)

54,181 (71)

57,553 (71)

58,678 (71.7)

64,696 (71.9)

67,713 (71.9)

 = 

 Intermediate care facilities

151,357 (30.7)

17,917 (25.8)

21,415 (28)

24,475 (30.2)

26,486 (32.3)

29,721 (33)

31,343 (33.3)

↗

Characteristics of the patients

Baseline characteristics

 Age in years, median (IQR)

70 [59; 80]

70 [58; 79]

70 [58; 80]

70 [59; 80]

70 [59; 80]

70 [59; 80]

70 [60; 80]

↗

 Gender (female)

190,941 (38.7)

27,069 (39)

29,513 (38.7)

31,535 (38.9)

31,811 (38.8)

34,677 (38.6)

36,336 (38.6)

 = 

Comorbidities

 Myocardial infarction

90,838 (18.4)

12,922 (18.6)

13,913 (18.2)

15,084 (18.6)

15,111 (18.5)

16,656 (18.5)

17,152 (18.2)

 = 

 Congestive heart failure

147,098 (29.8)

19,920 (28.7)

22,285 (29.2)

24,281 (29.9)

24,767 (30.2)

27,548 (30.6)

28,297 (30.1)

↗

 Dementia

21,630 (4.4)

3090 (4.4)

3466 (4.5)

3631 (4.5)

3541 (4.3)

3911 (4.3)

3991 (4.2)

 = 

 Chronic pulmonary disease

80,759 (16.4)

10,835 (15.6)

12,109 (15.9)

13,237 (16.3)

13,073 (16)

15,206 (16.9)

16,299 (17.3)

↗

 Diabetes without chronic complication

81,220 (16.5)

11,171 (16.1)

11,832 (15.5)

13,319 (16.4)

13,739 (16.8)

15,467 (17.2)

15,692 (16.7)

↗

 Diabetes with chronic complications

46,219 (9.4)

6735 (9.7)

7175 (9.4)

7762 (9.6)

7490 (9.1)

8519 (9.5)

8538 (9.1)

↘

 Renal disease

61,383 (12.5)

7610 (11)

8875 (11.6)

10,003 (12.3)

10,266 (12.5)

12,231 (13.6)

12,398 (13.2)

↗

 Any malignancy

111,501 (22.6)

15,377 (22.1)

17,038 (22.3)

18,309 (22.6)

18,709 (22.8)

20,778 (23.1)

21,290 (22.6)

↗

 Moderate or severe liver disease

36,692 (7.4)

5306 (7.6)

5706 (7.5)

6115 (7.5)

6187 (7.6)

6559 (7.3)

6819 (7.2)

↘

 Metastatic solid tumor

37,339 (7.6)

4734 (6.8)

5516 (7.2)

6033 (7.4)

6311 (7.7)

7271 (8.1)

7474 (7.9)

↗

 Charlson score, median (IQR)

2 [1; 4]

2 [1; 4]

2 [1; 4]

2 [1; 4]

2 [1; 4]

2 [1; 4]

2 [1; 4]

↗

Illness severity

 Neurological organ failure

132,587 (26.9)

16,159 (23.3)

19,360 (25.4)

21,817 (26.9)

22,332 (27.3)

25,054 (27.9)

27,865 (29.6)

↗

 Renal organ failure

214,785 (43.6)

29,032 (41.8)

32,334 (42.3)

34,910 (43)

36,481 (44.6)

39,981 (44.5)

42,047 (44.7)

↗

 Respiratory organ failure

227,706 (46.2)

32,439 (46.7)

35,664 (46.7)

37,638 (46.4)

38,094 (46.5)

40,982 (45.6)

42,889 (45.5)

↘

 Number of organ failure, median (IQR)

4 [3; 5]

4 [3; 5]

4 [3; 5]

4 [3; 5]

4 [3; 5]

4 [3; 5]

4 [3; 5]

 = 

 SAPS II score, median (IQR) (miss = 83,156)

51 [38; 67]

51 [38; 67]

51 [38; 67]

51 [38; 67]

51 [38; 67]

51 [38; 67]

51 [38; 68]

↗

Outcomes

 Hospital LOS (days) (median [IQR])

20 [8; 39]

20 [8; 40]

20 [8; 39]

20 [8; 39]

20 [8; 39]

19 [8; 38]

19 [8; 37]

↘

 ICU LOS (days) (median [IQR]) (missing = 133,828)

8 [3; 18]

9 [3; 20]

9 [3; 19]

8 [3; 19]

8 [3; 18]

8 [3; 18]

8 [3; 17]

↘

 Discharge to home

199,613 (40.5)

27,067 (39)

30,521 (40)

32,755 (40.4)

32,810 (40.1)

37,433 (41.6)

39,027 (41.4)

↗

 Hospital mortality

222,709 (45.2)

32,091 (46.2)

34,967 (45.8)

37,007 (45.6)

37,146 (45.4)

39,872 (44.3)

41,626 (44.2)

↘

 Cost (€), median (IQR)

16,449

[7336; 29360]

17,261.7

[7604; 30765]

16,129.2

[6918; 29647]

15,886

[6889; 29107]

16,538.6

[7387; 29489]

16,640.1

[7560; 29172]

16,364.6

[7509; 28504]

↘