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Table 3 Toxicological assays

From: Management of pharmaceutical and recreational drug poisoning

Dosing methods Interest/limits
Immunological Plasma or serum Acetaminophen, salicylic acid (active metabolite of acetylsalicylic acid), digoxin, valproic acid Automated assays (available in less than 120 min)
Few potential interferences (kit-dependent)
Specific electrodes Plasma (without lithium heparin as anticoagulant) or serum Lithium
LC–MS/MS or GC–MS Plasma or serum Acetaminophen, salicylic acid (active metabolite of acetylsalicylic acid), digoxin, valproic acid No interference
Not automated, cannot be used in an emergency
Flame photometer Plasma or total blood (erythrocyte assay) Lithium
  1. LC–MS/MS liquid chromatography coupled with tandem mass spectrometry, GC–MS gas chromatography coupled with mass spectrometry