Table 1 Characteristics of neutropenic vs non-neutropenic patients
Non-neutropenic (n = 1316) | Neutropenic (n = 165) | p value | |
|---|---|---|---|
Age (median [IQR]) | 65 (55–72) | 59 (45.5–67) | < 0.001 |
Female | 529 (40.5) | 56 (34.1) | 0.14 |
SOFA (median [IQR]) | 6 (4–10) | 10 (7–12) | < 0.001 |
ECOG-PS (median [IQR]) | 1 (1–2) | 1 (1–2) | 0.51 |
Organ transplantation | 125 (10.6) | 3 (1.9) | 0.001 |
Leucocytes count at ICU admission(G/L) | 13 (6–27) | 0.00 (0.00–0.00) | < 0.001 |
Neutrophils count at ICU admission(G/L) | 10(4–23) | 0.00 (0.00–0.00) | < 0.001 |
Hematopoietic cell transplant (HCT) | < 0.001 | ||
No HCT | 1139 (86.6) | 107 (64.8) | |
Autologous HCT | 68 (5.2) | 26 (15.8) | |
Allogeneic HCT | 109 (8.3) | 32 (19.4) | |
Immune defect | < 0.001 | ||
Acute leukemia | 167 (12.7) | 70 (42.4) | |
Chronic leukemia | 68 (5.2) | 6 (3.6) | |
Hodgkin disease | 28 (2.1) | 5 (3) | |
Drug-induced immunosuppression | 105 (8) | 2 (1.2) | |
Myeloma | 122 (9.3) | 13 (7.9) | |
Non-Hodgkin lymphoma | 138 (10.5) | 33 (20) | |
Other | 103 (7.8) | 16 (9.7) | |
Solid tumor | 433 (32.9) | 19 (11.5) | |
Systemic | 152 (11.6) | 1 (0.6) | |
Comorbidities | |||
Diabetes | 266 (20.8) | 17 (10.8) | 0.004 |
Kidney | 209 (16.2) | 9 (5.6) | 0.001 |
Cirrhosis | 48 (3.7) | 4 (2.5) | 0.57 |
Respiratory support | 0.02 | ||
High-flow nasal oxygen | 138 (10.5) | 27 (16.4) | |
Non-invasive ventilation | 182 (13.8) | 20 (12.1) | |
O2 | 664 (50.5) | 91 (55.2) | |
Mechanical ventilation | 332 (25.2) | 27 (16.4) | |
Vasopressors | 732 (55.6) | 117 (70.9) | < 0.001 |
Renal replacement therapy | 208 (15.8) | 43 (26.1) | 0.001 |
Acute respiratory failure diagnosis (%) | < 0.001 | ||
Bacterial | 356 (27.1) | 79 (47.9) | |
Fungal | 74 (5.6) | 17 (10.3) | |
Other | 691 (52.5) | 53 (32.1) | |
Pneumocystis | 48 (3.6) | 3 (1.8) | |
Unknown | 147 (11.2) | 13 (7.9) | |
No BAL use | 823 (62.5) | 108 (65.5) | 0.52 |
ICU mortality | 417 (31.7) | 72 (43.6) | 0.003 |
Hospital mortality | 557 (42.2) | 89 (54) | 0.006 |