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Table 3 Multimodal perfusion comparison between both study groups at 6 h

From: Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial

 

CRT-targeted group

Lactate targeted group

P

MAP (mmHg)

70 [65–65]

73 [64–81]

0.6

CVP (mmHg)

9 [7–12]

10 [8–13]

0.54

Cardiac Index (l/m/m2)

2.7 [2.2–4]

3.1 [2.5–3.9]

0.4

Norepinephrine dose (mcg/kg/min)

0.33 [0.11–0.46]

0.21 [0.12–0.35]

0.26

Lactate (mmol/L)

2.3 [1.8–4]

3.5 [1.8–7.3]

0.37

CRT (s)

3 [2–5]

3 [2–5]

0.82

ScvO2 (%)

68 [66–76]

73 [61–82]

0.38

Delta pCO2(v-a)

5 [4–8]

5 [4–8]

0.89

P(cv-a)CO2/Da-vO2 ratio

1.58 [1.1–2]

1.8 [1–2.7]

0.6

L/P ratio

12 [6.1–22.2]

8.7 [4.5–12.4]

0.22

StO2 (%)

75 [70–85]

80 [68–85]

0.6

PDR-ICGa (%)

15.6 [12–24]

13 [6–14]

0.1

MFIa

2.5 [1.5–3]

3 [2.7–3]

0.09

  1. Data are presented as percentage (absolute number) or median [interquartile range]
  2. CRT Capillary refill time, MAP mean arterial pressure, CVP Central venous pressure, ScvO2 central venous oxygen saturation, Delta pCO2(v-a) Difference between central venous carbon dioxide pressure and arterial carbon dioxide pressure, P(cv-a)CO2/Da-vO2 ratio central venous-arterial pCO2 gradient/ arterial-venous O2 content difference ratio, L/P ratio lactate-piruvate ratio, StO2 Thenar muscle saturation, PDR-ICG Indocianine greeen plasma disappearance rate, MFI microcirculatory flow index
  3. aAssessed only at Hospital Clínico UC CHRISTUS