Table 2 Clinical data, arterial blood gases, and echocardiographic findings with the administration of inhaled nitric oxide (iNO) and almitrine in patients with severe acute respiratory distress syndrome secondary to coronavirus disease 2019

Clinical parameters

 Systolic arterial pressure (mmHg)

141 (122–148)

131 (115–146)

131 (117–145)

 Diastolic arterial pressure (mmHg)

58 (56–73)

60 (51–73)

57 (47–74)

 Mean arterial pressure (mmHg)

82 (66–94)

80 (70–95)

78 (73–96)

 Heart rate (rpm)

102 (86–111)

95 (86–117)

93 (87–116)

 Pulse oxygen saturation (%)

98 (95–99)

98 (97–99)

100 (98–100)^a,b

Arterial blood gas

 FiO₂

1

1

1

 pH

7.30 (7.29–7.36)

7.32 (7.30–7.37)^a

7.32 (7.30–7.39)^a

 PaO₂ (mmHg)

102 (89–134)

124 (108–146)

180 (132–206)^a,b

 PaCO₂ (mmHg)

48 (40–55)

45 (40–60)

46 (39–56)

 Bicarbonates (mmol/L)

26 (23–32)

26 (22–32)

28 (23–31)

 SaO₂ (%)

97 (94–97)

98 (96–98)

99 (98–99)^a

 Lactate (mmol/L)

1.1 (0.9–1.5)

1.0 (0.9–1.6)

1.1 (0.9–1.8)

Echocardiographic parameters

 VTI LVOT (cm)

17 (15–22)

16 (15–21)

20 (17–25)

 Cardiac index (L/min/m²)

3.2 (2.2–4.1)

2.8 (2.2–3.6)

2.9 (2.7–4.2)

 TR velocity peak (m/s)

2.8 (2.1–3.1)

2.2 (2.0–2.9)

2.7 (2.1–3.0)

 LV eccentricity index

0.95 (0.9–1.0)

0.97 (0.92–1.0)

0.97 (0.84–1.0)

 RV/LV surface ratio

0.5 (0.41–0.54)

0.44 (0.37–0.57)

0.49 (0.45–0.63)