Protracted viral shedding and viral load are associated with ICU mortality in Covid-19 patients with acute respiratory failure

Annals of Intensive Care

Table 2 Fine and gray competing risk regression of the probability of SARS-CoV-2 RT-PCR negativation

Variable	Univariate SHR [CI_95 %]	Univariate p value	Multivariate SHR [CI_95 %]	Multivariate p value
Vital status at ICU discharge * (ref = alive)	0.13 [0.07–0.25]	< 0.0001	0.15 [0.08–0.28]	< 0.0001
Age (per 1-year increment)	0.96 [0.94–0.98]	< 0.001	0.98 [0.96–0.99]	< 0.01
Antiviral treatment (ref = no)	2.19 [1.20–4.01]	< 0.05	2.38 [1.34–4.25]	< 0.01
Immunodeficiency (ref = no)	0.24 [0.06–0.96]	< 0.05	–	NS
SOFA at ICU admission (per 1-point increment)	0.95 [0.88–1.02]	0.16	–	NS
Sex (ref = male)	0.78 [0.49–1.22]	0.28	–	NS
Center (ref = center#1)	2.22 [1.45–3.40]	< 0.001	–	NS

CI_95 % 95% confidence interval, ICU intensive care unit, NS non-significant, ref reference, RT-PCR real-time reverse transcriptase polymerase chain reaction, SHR subdistribution hazard ratio