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Table 3 Time course of echocardiographic parameters during the study protocol

From: Ultraprotective ventilation allowed by extracorporeal CO2 removal improves the right ventricular function in acute respiratory distress syndrome patients: a quasi-experimental pilot study

Parameter ECCO2R Analysis of variance p
VT 6 mL/kg (n = 18) VT 6 mL/kg (n = 18) VT 4 mL/kg (n = 18) VT 4 mL/kg (n = 16) VT 6 mL/kg (n = 17)
Day 0 Day 1
Left ventricular function
 LVEF at baseline 57.5 (50–60.8)      
 VTIAo (cm) 18.3 (15.7–22.1) 20.3 (16.6–22.9) 21.9 (16.2–24) 22.1 (19–25.4)* 20.8 (16.5–24.9) 0.03
 LV end-diastolic diameter (cm) 4.8 (3.8–5.9) 4.7 (4–5.4) 4.8 (4–5.9) 4.4 (4–4.7) 4.5 (4–5.6) 0.6
 LV end-systolic diameter(cm) 3.3 (2.9–4.2) 3.2 (2.8–4.3) 3.7 (2.9–4.2) 2.9 (2.8–3.5) 3.5 (2.8–4.1) 0.6
Left ventricular filling pressures estimation
 E velocity (m/s) 77.6 (61.4–91.5) 73.7 (64.9–101.3) 79.7 (69.8–100.8) 78.6 (66.9–95.4) 78 (63.6–96.6) 0.9
 E/A ratio 1.02 (0.95–1.24) 1.04 (0.89–1.24) 1.11 (0.94–1.43) 1 (0.89–1.18) 0.98 (0.86–1.25) 0.7
 E’ velocity (m/s) 8.43 (7.92–9.86) 10 (7.67–12.3) 9.72 (8.04–11.7) 9.63 (6.91–11.2) 9.32 (7.47–10.7) 0.9
 E/E’ ratio 8.47 (7.28–11.05) 8.51 (7.28–11.3) 8.58 (6.74–11.12) 7.49 (7.15–9.47) 8.19 (7.13–9.88) 0.9
Right ventricular function
 S’ velocity (cm/s) 13.8 (12.5–15.3) 13.1 (12–14.2) 14.8 (12–15.9) 15.1 (14.3–17.2)* 14.7 (11.5–16.6) 0.1
 TAPSE (mm) 22.9 (19.2–24.3) 25 (19.8–27) 25.4 (21.4–27.9)* 24.1 (21.4–26.9) 23.8 (20.8–26) 0.02
 Paradoxical septal motion (n) 0 0 0 0 0
 Tricuspid regurgitation gradient (mmHg) 27 (24–34) 29 (24–33) 33 (28–37) 30 (27–40) 29 (24–37) 0.7
 sPAP estimation (mmHg) 44 (40–52) 43 (38–49) 42 (38–51) 46 (40–56) 44 (42–53) 0.7
Right ventricular preload
 RV/LV ratio 0.74 (0.57–0.79) 0.71 (0.61–0.77) 0.68 (0.62–0.74) 0.64 (0.59–0.81) 0.73 (0.61–0.79) 0.8
 RA pressure estimation (mmHg) 15 (15–19) 15 (10–19) 15 (10–15) 15 (14–15) 15 (15–20) 0.2
 Distensibility index 11.2 (5.2–20.8) 12.4 (5.4–25.1) 10.7 (6.8–22.3) 10.6 (6.5–16.9) 9.5 (6.1–14) 0.6
  1. LVEF left ventricular ejection fraction, VTIAo aortic velocity time integral, E early diastolic mitral inflow velocity; E’ early diastolic septal mitral annular velocity, A: atrial contraction mitral inflow velocity, S’ right ventricle systolic excursion velocity, TAPSE tricuspid annular plane systolic excursion, sPAP systolic pulmonary arterial pressure, RV/LV ratio right/left ventricular end-diastolic diameter (RV/LV) ratio, RA right atrial
  2. *p < 0.05 vs baseline