Table 3 Time course of echocardiographic parameters during the study protocol
Parameter | ECCO2R | Analysis of variance p | ||||
|---|---|---|---|---|---|---|
VT 6 mL/kg (n = 18) | VT 6 mL/kg (n = 18) | VT 4 mL/kg (n = 18) | VT 4 mL/kg (n = 16) | VT 6 mL/kg (n = 17) | ||
Day 0 | Day 1 | |||||
Left ventricular function | ||||||
LVEF at baseline | 57.5 (50–60.8) | |||||
VTIAo (cm) | 18.3 (15.7–22.1) | 20.3 (16.6–22.9) | 21.9 (16.2–24) | 22.1 (19–25.4)* | 20.8 (16.5–24.9) | 0.03 |
LV end-diastolic diameter (cm) | 4.8 (3.8–5.9) | 4.7 (4–5.4) | 4.8 (4–5.9) | 4.4 (4–4.7) | 4.5 (4–5.6) | 0.6 |
LV end-systolic diameter(cm) | 3.3 (2.9–4.2) | 3.2 (2.8–4.3) | 3.7 (2.9–4.2) | 2.9 (2.8–3.5) | 3.5 (2.8–4.1) | 0.6 |
Left ventricular filling pressures estimation | ||||||
E velocity (m/s) | 77.6 (61.4–91.5) | 73.7 (64.9–101.3) | 79.7 (69.8–100.8) | 78.6 (66.9–95.4) | 78 (63.6–96.6) | 0.9 |
E/A ratio | 1.02 (0.95–1.24) | 1.04 (0.89–1.24) | 1.11 (0.94–1.43) | 1 (0.89–1.18) | 0.98 (0.86–1.25) | 0.7 |
E’ velocity (m/s) | 8.43 (7.92–9.86) | 10 (7.67–12.3) | 9.72 (8.04–11.7) | 9.63 (6.91–11.2) | 9.32 (7.47–10.7) | 0.9 |
E/E’ ratio | 8.47 (7.28–11.05) | 8.51 (7.28–11.3) | 8.58 (6.74–11.12) | 7.49 (7.15–9.47) | 8.19 (7.13–9.88) | 0.9 |
Right ventricular function | ||||||
S’ velocity (cm/s) | 13.8 (12.5–15.3) | 13.1 (12–14.2) | 14.8 (12–15.9) | 15.1 (14.3–17.2)* | 14.7 (11.5–16.6) | 0.1 |
TAPSE (mm) | 22.9 (19.2–24.3) | 25 (19.8–27) | 25.4 (21.4–27.9)* | 24.1 (21.4–26.9) | 23.8 (20.8–26) | 0.02 |
Paradoxical septal motion (n) | 0 | 0 | 0 | 0 | 0 | – |
Tricuspid regurgitation gradient (mmHg) | 27 (24–34) | 29 (24–33) | 33 (28–37) | 30 (27–40) | 29 (24–37) | 0.7 |
sPAP estimation (mmHg) | 44 (40–52) | 43 (38–49) | 42 (38–51) | 46 (40–56) | 44 (42–53) | 0.7 |
Right ventricular preload | ||||||
RV/LV ratio | 0.74 (0.57–0.79) | 0.71 (0.61–0.77) | 0.68 (0.62–0.74) | 0.64 (0.59–0.81) | 0.73 (0.61–0.79) | 0.8 |
RA pressure estimation (mmHg) | 15 (15–19) | 15 (10–19) | 15 (10–15) | 15 (14–15) | 15 (15–20) | 0.2 |
Distensibility index | 11.2 (5.2–20.8) | 12.4 (5.4–25.1) | 10.7 (6.8–22.3) | 10.6 (6.5–16.9) | 9.5 (6.1–14) | 0.6 |