Table 1 General characteristics of the patients at inclusion
General data | Total population | Non-responders | Responders |
|---|---|---|---|
(n = 81) | (n = 40) | (n = 41) | |
Age (year) | 64 (54; 73) | 63 (51; 76) | 64 (55; 72) |
Sex ratio female/male | 27/54 | 15/25 | 12/29 |
Height (m) | 1.71 (1.65;Â 1.76) | 1.69 (1.63;Â 1.75) | 1.72 (1.65;Â 1.80) |
Weight (kg) | 73 (60;Â 89) | 70 (60;Â 85) | 77.5 (60;Â 90) |
SAPS II | 34 (24; 42) | 37 (28; 48) | 31 (22; 39) |
Pre-existing conditions | |||
 Arterial hypertension | 31 (38) | 17 (43) | 14 (34) |
 Chronic left ventricular failure | 8 (10) | 4 (10) | 4 (10) |
 Chronic right ventricular failure | 3 (4) | 2 (5) | 1 (2) |
 Atrial fibrillation | 18 (22) | 8 (20) | 10 (24) |
 COPD | 17 (21) | 9 (23) | 8 (20) |
 Chronic pulmonary hypertension | 6 (7) | 5 (13) | 1 (2) |
 Pulmonary embolism | 2 (3) | 0 (0) | 2 (5) |
 Arteriopathy | 9 (11) | 7 (18) | 2 (5) |
Sepsis | |||
 Pulmonary | 49 (61) | 24 (60) | 25 (61) |
 Skin and soft tissue | 13 (16) | 7 (18) | 6 (15) |
 Abdominal | 10 (12) | 5 (13) | 5 (12) |
 Urinary | 6 (7) | 3 (8) | 3 (8) |
 Other infections | 3 (4) | 1 (3) | 2 (5) |
Hemodynamic parameters | |||
 Mean arterial pressure (mm Hg) | 68 (61; 79) | 67(61; 77) | 70 (61; 83) |
 Heart rate (beats/min) | 107 (88; 120) | 98 (83; 114) | 109 (102; 126) |
 LVOT VTI (cm) | 16.4 (13.2; 19.7) | 17.4 (15.2; 21) | 14.8 (12; 18.4) |
 Cardiac index (L/min/m2) | 2.9 (2.3; 3.7) | 2.9 (2.5; 4.1) | 2.9 (2.2; 3.3) |
 Norepinephrine | 16 (20) | 13 (33) | 3 (7) |
 Norepinephrine µg/kg/min | 0.23 (0.17; 0.36) | 0.25 (0.14; 0.35) | 0.22 (0.19; 0.37) |
 VE in last 24 h (mL) | 1000 (0; 2000) | 1000 (0; 2000) | 1000 (30; 1700) |
 Oliguria | 39 (48) | 18 (45) | 21 (51) |
 Arterial hypotension | 38 (47) | 19 (48) | 19 (46) |
Tachycardia | 57 (70) | 24 (60) | 33 (80) |
 Mottled skin | 23 (28) | 15 (38) | 8 (20) |