|
General data
|
Total population
|
Non-responders
|
Responders
|
|---|
|
(n = 81)
|
(n = 40)
|
(n = 41)
|
|---|
|
Age (year)
|
64 (54; 73)
|
63 (51; 76)
|
64 (55; 72)
|
|
Sex ratio female/male
|
27/54
|
15/25
|
12/29
|
|
Height (m)
|
1.71 (1.65; 1.76)
|
1.69 (1.63; 1.75)
|
1.72 (1.65; 1.80)
|
|
Weight (kg)
|
73 (60; 89)
|
70 (60; 85)
|
77.5 (60; 90)
|
|
SAPS II
|
34 (24; 42)
|
37 (28; 48)
|
31 (22; 39)
|
|
Pre-existing conditions
|
|
Arterial hypertension
|
31 (38)
|
17 (43)
|
14 (34)
|
|
Chronic left ventricular failure
|
8 (10)
|
4 (10)
|
4 (10)
|
|
Chronic right ventricular failure
|
3 (4)
|
2 (5)
|
1 (2)
|
|
Atrial fibrillation
|
18 (22)
|
8 (20)
|
10 (24)
|
|
COPD
|
17 (21)
|
9 (23)
|
8 (20)
|
|
Chronic pulmonary hypertension
|
6 (7)
|
5 (13)
|
1 (2)
|
|
Pulmonary embolism
|
2 (3)
|
0 (0)
|
2 (5)
|
|
Arteriopathy
|
9 (11)
|
7 (18)
|
2 (5)
|
|
Sepsis
|
|
Pulmonary
|
49 (61)
|
24 (60)
|
25 (61)
|
|
Skin and soft tissue
|
13 (16)
|
7 (18)
|
6 (15)
|
|
Abdominal
|
10 (12)
|
5 (13)
|
5 (12)
|
|
Urinary
|
6 (7)
|
3 (8)
|
3 (8)
|
|
Other infections
|
3 (4)
|
1 (3)
|
2 (5)
|
|
Hemodynamic parameters
|
|
Mean arterial pressure (mm Hg)
|
68 (61; 79)
|
67(61; 77)
|
70 (61; 83)
|
|
Heart rate (beats/min)
|
107 (88; 120)
|
98 (83; 114)
|
109 (102; 126)
|
|
LVOT VTI (cm)
|
16.4 (13.2; 19.7)
|
17.4 (15.2; 21)
|
14.8 (12; 18.4)
|
|
Cardiac index (L/min/m2)
|
2.9 (2.3; 3.7)
|
2.9 (2.5; 4.1)
|
2.9 (2.2; 3.3)
|
|
Norepinephrine
|
16 (20)
|
13 (33)
|
3 (7)
|
|
Norepinephrine µg/kg/min
|
0.23 (0.17; 0.36)
|
0.25 (0.14; 0.35)
|
0.22 (0.19; 0.37)
|
|
VE in last 24 h (mL)
|
1000 (0; 2000)
|
1000 (0; 2000)
|
1000 (30; 1700)
|
|
Oliguria
|
39 (48)
|
18 (45)
|
21 (51)
|
|
Arterial hypotension
|
38 (47)
|
19 (48)
|
19 (46)
|
|
Tachycardia
|
57 (70)
|
24 (60)
|
33 (80)
|
|
Mottled skin
|
23 (28)
|
15 (38)
|
8 (20)
|
- Values are expressed as counts (%) or medians and interquartile ranges (25th; 75th centiles). COPD chronic obstructive pulmonary disease, SAPS Simplify Acute Physiology Score, LVOT VTI left ventricular outflow tract velocity time integral, VE volume expansion
