Biomarkers and clinical scores to aid the identification of disease severity and intensive care requirement following activation of an in-hospital sepsis code

Annals of Intensive Care

Table 2 28-day mortality prediction in patients with either community or hospital-acquired infections

	Biomarker or clinical score	Patients (N)	Events (N)	AUROC	Univariate		Bivariate
	Biomarker or clinical score	Patients (N)	Events (N)	AUROC	LR χ²	HR IQR [95% CI]	LR χ²	HR IQR [95% CI]
Community	MR-proADM	67	15	0.76 [0.64–0.89]	13.08	4.60 [1.95–10.83]	14.52	4.88 [1.96–12.14]
	PCT	65	15	0.54 [0.36–0.71]	0.09	0.89 [0.43–1.85]	1.64	0.89 [0.43–1.85]
	CRP	66	15	0.57 [0.40–0.74]	0.48	1.28 [0.62–2.63]	2.30	1.32 [0.62–2.80]
	Lactate	60	14	0.71 [0.53–0.89]	10.03	3.44 [1.59–7.45]	10.61	3.09 [1.40–6.83]
	APACHE II	33	8	0.70 [0.50–0.90]	2.10	2.07 [0.77–5.55]	2.79	2.14 [0.76–6.03]
	SOFA	67	15	0.73 [0.57–0.88]	8.93	2.85 [1.39–5.85]	11.16	3.01 [1.44–6.28]
Hospital	MR-proADM	48	11	0.66 [0.45–0.88]	5.59	3.15 [1.19–8.37]	5.70	3.32 [1.19–9.25]
	PCT	48	11	0.46 [0.27–0.65]	0.03	0.91 [0.30–2.77]	0.19	0.88 [0.29–2.70]
	CRP	48	11	0.53 [0.32–0.73]	0.52	1.20 [0.70–2.07]	0.61	1.19 [0.69–2.06]
	Lactate	43	10	0.58 [0.35–0.81]	0.87	1.40 [0.70–2.77]	0.87	1.40 [0.70–2.77]
	APACHE II	25	6	0.63 [0.37–0.89]	0.85	0.61 [0.21–1.74]	1.18	0.58 [0.19–1.75]
	SOFA	48	11	0.78 [0.61–0.95]	12.12	3.60 [1.70–7.59]	12.18	3.58 [1.70–7.55]

APACHE II Acute Physiological and Chronic Health Evaluation II score, AUROC area under the receiver operating characteristic curve, CI confidence interval, CRP C-reactive protein, HR hazard ratio, IQR interquartile range, LR likelihood ratio of the χ² test, MR-proADM mid-regional proadrenomedullin, N number, PCT procalcitonin, SOFA Sequential Organ Failure Assessment score