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Table 2 28-day mortality prediction in patients with either community or hospital-acquired infections

From: Biomarkers and clinical scores to aid the identification of disease severity and intensive care requirement following activation of an in-hospital sepsis code

 Biomarker or clinical scorePatients (N)Events (N)AUROCUnivariateBivariate
LR χ2HR IQR [95% CI]LR χ2HR IQR [95% CI]
CommunityMR-proADM67150.76 [0.64–0.89]13.084.60 [1.95–10.83]14.524.88 [1.96–12.14]
PCT65150.54 [0.36–0.71]0.090.89 [0.43–1.85]1.640.89 [0.43–1.85]
CRP66150.57 [0.40–0.74]0.481.28 [0.62–2.63]2.301.32 [0.62–2.80]
Lactate60140.71 [0.53–0.89]10.033.44 [1.59–7.45]10.613.09 [1.40–6.83]
APACHE II3380.70 [0.50–0.90]2.102.07 [0.77–5.55]2.792.14 [0.76–6.03]
SOFA67150.73 [0.57–0.88]8.932.85 [1.39–5.85]11.163.01 [1.44–6.28]
HospitalMR-proADM48110.66 [0.45–0.88]5.593.15 [1.19–8.37]5.703.32 [1.19–9.25]
PCT48110.46 [0.27–0.65]0.030.91 [0.30–2.77]0.190.88 [0.29–2.70]
CRP48110.53 [0.32–0.73]0.521.20 [0.70–2.07]0.611.19 [0.69–2.06]
Lactate43100.58 [0.35–0.81]0.871.40 [0.70–2.77]0.871.40 [0.70–2.77]
APACHE II2560.63 [0.37–0.89]0.850.61 [0.21–1.74]1.180.58 [0.19–1.75]
SOFA48110.78 [0.61–0.95]12.123.60 [1.70–7.59]12.183.58 [1.70–7.55]
  1. APACHE II Acute Physiological and Chronic Health Evaluation II score, AUROC area under the receiver operating characteristic curve, CI confidence interval, CRP C-reactive protein, HR hazard ratio, IQR interquartile range, LR likelihood ratio of the χ2 test, MR-proADM mid-regional proadrenomedullin, N number, PCT procalcitonin, SOFA Sequential Organ Failure Assessment score