Biomarkers and clinical scores to aid the identification of disease severity and intensive care requirement following activation of an in-hospital sepsis code

Annals of Intensive Care

Table 3 28-day mortality prediction in patients enrolled following either surgical or medical complaints

	Biomarker or clinical score	Patients (N)	Events (N)	AUROC	Univariate		Bivariate
	Biomarker or clinical score	Patients (N)	Events (N)	AUROC	LR χ²	HR IQR [95% CI]	LR χ²	HR IQR [95% CI]
Surgical	MR-proADM	47	10	0.80 [0.66–0.94]	9.03	6.53 [1.65–25.88]	10.40	6.34 [1.84–41.04]
	PCT	47	10	0.47 [0.26–0.68]	0.34	1.39 [0.46–4.21]	0.68	1.56 [0.48–5.10]
	CRP	47	10	0.59 [0.38–0.79]	0.37	1.24 [0.60–2.58]	0.55	1.26 [0.60–2.63]
	Lactate	44	8	0.73 [0.49–0.97]	3.97	2.72 [1.00–7.39]	4.06	2.65 [0.98–7.20]
	APACHE II	29	7	0.53 [0.29–0.77]	0.01	1.05 [0.39–2.80]	0.78	0.86 [0.29–2.53]
	SOFA	47	10	0.74 [0.56–0.92]	10.86	5.05 [1.82–14.02]	11.12	5.55 [1.87–16.46]
Medical	MR-proADM	83	18	0.72 [0.57–0.87]	15.05	3.84 [1.96–7.54]	16.32	3.87 [1.90–7.86]
	PCT	80	18	0.55 [0.40–0.71]	0.10	0.89 [0.44–1.79[	2.89	0.90 [0.45–1.80]
	CRP	82	18	0.46 [0.30–0.61]	0.63	1.23 [0.71–2.15]	3.49	1.27 [0.70–2.29]
	Lactate	72	18	0.66 [0.51–0.82]	6.43	2.06 [1.21–3.51]	7.84	1.99 [1.14–3.46]
	APACHE II	35	7	0.59 [0.34–0.82]	0.20	1.28 [0.44–1.79]	0.43	1.17 [0.38–3.59]
	SOFA	83	18	0.71 [0.57–0.86]	16.32	3.87 [1.90–7.86]	13.33	2.50 [1.43–4.36]

APACHE II Acute Physiological and Chronic Health Evaluation II score, AUROC area under the receiver operating characteristic curve, CI confidence interval, CRP C-reactive protein, HR hazard ratio, IQR interquartile range, LR likelihood ratio of the χ² test, MR-proADM mid-regional proadrenomedullin, N number, PCT procalcitonin, SOFA Sequential Organ Failure Assessment score