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Table 3 28-day mortality prediction in patients enrolled following either surgical or medical complaints

From: Biomarkers and clinical scores to aid the identification of disease severity and intensive care requirement following activation of an in-hospital sepsis code

 Biomarker or clinical scorePatients (N)Events (N)AUROCUnivariateBivariate
LR χ2HR IQR [95% CI]LR χ2HR IQR [95% CI]
SurgicalMR-proADM47100.80 [0.66–0.94]9.036.53 [1.65–25.88]10.406.34 [1.84–41.04]
PCT47100.47 [0.26–0.68]0.341.39 [0.46–4.21]0.681.56 [0.48–5.10]
CRP47100.59 [0.38–0.79]0.371.24 [0.60–2.58]0.551.26 [0.60–2.63]
Lactate4480.73 [0.49–0.97]3.972.72 [1.00–7.39]4.062.65 [0.98–7.20]
APACHE II2970.53 [0.29–0.77]0.011.05 [0.39–2.80]0.780.86 [0.29–2.53]
SOFA47100.74 [0.56–0.92]10.865.05 [1.82–14.02]11.125.55 [1.87–16.46]
MedicalMR-proADM83180.72 [0.57–0.87]15.053.84 [1.96–7.54]16.323.87 [1.90–7.86]
PCT80180.55 [0.40–0.71]0.100.89 [0.44–1.79[2.890.90 [0.45–1.80]
CRP82180.46 [0.30–0.61]0.631.23 [0.71–2.15]3.491.27 [0.70–2.29]
Lactate72180.66 [0.51–0.82]6.432.06 [1.21–3.51]7.841.99 [1.14–3.46]
APACHE II3570.59 [0.34–0.82]0.201.28 [0.44–1.79]0.431.17 [0.38–3.59]
SOFA83180.71 [0.57–0.86]16.323.87 [1.90–7.86]13.332.50 [1.43–4.36]
  1. APACHE II Acute Physiological and Chronic Health Evaluation II score, AUROC area under the receiver operating characteristic curve, CI confidence interval, CRP C-reactive protein, HR hazard ratio, IQR interquartile range, LR likelihood ratio of the χ2 test, MR-proADM mid-regional proadrenomedullin, N number, PCT procalcitonin, SOFA Sequential Organ Failure Assessment score