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Table 2 Characteristics of sepsis patients categorized by overlap of Sepsis-3 and eSOFA criteria (Adult Sepsis Event)

From: External validity of Adult Sepsis Event’s simplified eSOFA criteria: a retrospective analysis of patients with confirmed infection in China

CharacteristicSepsis-3 (−)
eSOFA (−)
n = 683
Sepsis-3 (+)
eSOFA (−)
n = 460
Sepsis-3 (−)
eSOFA (+)
n = 98
Sepsis-3 (+)
eSOFA (+)
n = 475
Median age (IQR)77 (56–84)81 (73–85)**81 (73–86)**82 (75–87)**
Gender, n (%)    
 Male359 (52.6)283 (61.5)**43 (43.9)291 (61.3)**
BMI, kg/m2, median (IQR)24 (21–26)23 (20–26)*24 (20–25)23 (20–26)*
Bedridden, n (%)336 (49.2)242 (52.6)**52 (53.1)260 (54.7)**
Type of hospital admission, n (%)    
 Medical610 (89.3)437 (95.0)**81 (82.7)425 (89.5)
 Elective surgery66 (9.7)19 (4.1)**9 (9.2)34 (7.2)
 Emergency surgery7 (1.0)4 (0.9)8 (8.2)**16 (3.4)**
McCabe and Jackson classification, n (%)    
 Nonfatal464 (67.9)350 (76.1)**60 (61.2)334 (70.3)
 Ultimately fatal90 (13.2)79 (17.2)22 (22.4)*98 (20.6)**
 Rapidly fatal14 (2.0)7 (1.5)8 (8.2)**16 (3.4)
Charlson Comorbidity Index, median (IQR)1 (0–3)2 (1–3)**2 (1–3)**2 (1–3)**
Comorbidities (Charlson), n (%)    
 Cancera103 (15.1)71 (15.4)30 (30.6)**101 (21.3)**
 Congestive heart failure5 (0.7)7 (1.5)4 (4.1)**24 (5.1)**
 Chronic pulmonary disease121 (17.7)116 (25.2)**29 (29.6)**119 (25.1)**
 Diabetes181 (26.5)147 (32.0)*25 (25.5)101 (21.3)*
 Liver disease9 (1.3)6 (1.3)4 (4.1)*13 (2.7)
 Renal disease7 (1.0)39 (8.5)**3 (3.1)28 (5.9)**
Chronic organ dysfunction (APACHE II), n (%)    
 Cardiovascular4 (0.6)7 (1.5)4 (4.1)**22 (4.6)**
 Respiratory16 (2.3)21 (4.6)*26 (26.5)**44 (9.3)**
 Liver9 (1.3)6 (1.3)4 (4.1)*13 (2.7)
 Renal6 (0.9)28 (6.1)**4 (4.1)**17 (3.6)**
 Immunosuppression56 (8.2)38 (8.3)6 (6.1)51 (10.7)
Site of infection, n (%)    
 Pneumonia369 (54.0)291 (63.3)**63 (64.3)311 (65.5)**
 Urogenital tract infection65 (9.5)25 (5.4)*3 (3.1)*8 (1.7)**
 Intra-abdominal infection72 (10.5)33 (7.2)9 (9.2)63 (13.3)
 Skin/soft tissue infection22 (3.2)3 (0.7)**2 (2.0)†1 (0.2)**
 Septicemia/bacteremia15 (2.2)3 (0.7)*3 (3.1)10 (2.1)
 Two or more infections41 (6.0)20 (4.3)14 (14.3)**52 (10.9)**
Outcomes    
 Median hospital LOS (IQR)17 (9–28)17 (10–33)23 (11–38)*23 (11–41)**
 Required ICU admission, n (%)7 (1.0)26 (5.7)**9 (9.2)**207 (43.6)**
 Death, n (%)38 (5.6)48 (10.4)**16 (16.3)**251 (52.8)**
  1. IQR interquartile range, BMI body mass index, LOS length of stay
  2. *p < 0.05, **p < 0.01, compared with eSOFA(−)Sepsis(−); p < 0.05, p < 0.01, compared with eSOFA(+)Sepsis(+)
  3. aCancer includes solid tumor with or without metastases, leukemia, and lymphoma