Table 2 Criteria leading to classification as severe malaria on admission

Neurological failure: obnubilation, confusion, GCS < 11 or multiple seizures

68 (36)

35 (36)

33 (36)

0.94

 Glasgow Coma Scale < 11

17 (9)

12 (12)

5 (5)

0.13

 Multiples seizures

8 (4)

6 (6)

2 (2)

0.18

Respiratory failure

11 (6)

5 (5)

6 (7)

0.66

Cardio-circulatory failure

36 (19)

16 (16)

20 (22)

0.31

Hemorrhage

3 (2)

2 (2)

1 (1)

0.6

Clinical jaundice or bilirubin > 50 µmol/L

73 (39)

42 (43)

31 (34)

0.21

Hyperlactatemia > 2 mmol/L

77 (41)

42 (43)

35 (38)

0.54

 Lactate, median [IQR]

2.1 [1.2; 3.2]

2.1 [1.2; 3.5]

1.8 [1.2; 2.8]

0.32

Acidosis: pH < 7.35

21 (11)

14 (14)

7 (8)

0.15

 pH, median [IQR]

7.4 [7.4; 7.5]

7.4 [7.4; 7.5]

7.4 [7.4; 7.5]

0.2

Renal impairment: serum creatinine > 265 µmol/L

45 (24)

29 (30)

16 (18)

0.05

 Creatinine, median [IQR]

120 [82; 247]

140 [92; 280]

107 [77; 197]

< .01

Hyperparasitemia > 4%

112 (59)

59 (60)

53 (58)

0.78

 Parasitemia, median in % [IQR]

5.3 [1.5; 9]

5.3 [2, 10]

5.3 [1.2; 7.7]

0.3

Hypoglycemia: blood glucose < 2.2 mmol/L

1 (0.5))

1 (1)

0 (0)

–

Severe anemia: hemoglobin < 7 g/dL

22 (12)

15 (15)

7 (8)

0.1

Number of severe criteria, median [IQR]

2 [1, 4]

2 [1, 4]

2 [1, 3]

0.28