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Table 2 Criteria leading to classification as severe malaria on admission

From: Changes in the clinical presentation and outcomes of patients treated for severe malaria in a referral French university intensive care unit from 2004 to 2017

Severe malaria criteriaTotal2004–20122013-2017p value
Neurological failure: obnubilation, confusion, GCS < 11 or multiple seizures68 (36)35 (36)33 (36)0.94
 Glasgow Coma Scale < 1117 (9)12 (12)5 (5)0.13
 Multiples seizures8 (4)6 (6)2 (2)0.18
Respiratory failure11 (6)5 (5)6 (7)0.66
Cardio-circulatory failure36 (19)16 (16)20 (22)0.31
Hemorrhage3 (2)2 (2)1 (1)0.6
Clinical jaundice or bilirubin > 50 µmol/L73 (39)42 (43)31 (34)0.21
Hyperlactatemia > 2 mmol/L77 (41)42 (43)35 (38)0.54
 Lactate, median [IQR]2.1 [1.2; 3.2]2.1 [1.2; 3.5]1.8 [1.2; 2.8]0.32
Acidosis: pH < 7.3521 (11)14 (14)7 (8)0.15
 pH, median [IQR]7.4 [7.4; 7.5]7.4 [7.4; 7.5]7.4 [7.4; 7.5]0.2
Renal impairment: serum creatinine > 265 µmol/L45 (24)29 (30)16 (18)0.05
 Creatinine, median [IQR]120 [82; 247]140 [92; 280]107 [77; 197]< .01
Hyperparasitemia > 4%112 (59)59 (60)53 (58)0.78
 Parasitemia, median in % [IQR]5.3 [1.5; 9]5.3 [2, 10]5.3 [1.2; 7.7]0.3
Hypoglycemia: blood glucose < 2.2 mmol/L1 (0.5))1 (1)0 (0)
Severe anemia: hemoglobin < 7 g/dL22 (12)15 (15)7 (8)0.1
Number of severe criteria, median [IQR]2 [1, 4]2 [1, 4]2 [1, 3]0.28
  1. GCS: Glasgow Coma Scale; IQR: interquartile range