Changes in the clinical presentation and outcomes of patients treated for severe malaria in a referral French university intensive care unit from 2004 to 2017

Annals of Intensive Care

Table 5 Independent predictors of poor outcome at ICU admission, multivariate analysis

Patients characteristics	Estimate	Std error	adjOR	95% CI	p value
Ethnic group					0.31
Caucasian and others	Ref		1
African	− 0.53	0.53	0.59	[0.21; 1.65]
Treatment administered					0.21
Artesunate	Ref		1
Intravenous quinine	1.23	0.99	3.43	[0.49; 23.9]
Severity criteria on admission
Neurological failure	1.17	0.58	3.23	[1.03; 10.08]	0.04
Cardio-circulatory failure	2.3	0.74	9.92	[2.34; 42]	< .01
Serum creatinine > 265 µmol/L	2.38	0.62	10.76	[3.17; 36.56]	< .01

Std error: standard error; adjOR: adjusted odds ratio; 95% CI: 95% confidence interval
NB: variables entered in the stepwise logistic regression model at the first step were: ethnic group; parasitemia greater than 4%, neurological failure; shock; lactate level greater than 1_8 mmol/L; pH < 7.35; serum creatinine > 265 µmol/L; bilirubin level > 50 IU; clinical history of prior malaria; cause of travel