All | Low GV | High CV | p value | |
---|---|---|---|---|
(MAGE ≦ 65) | (MAGE > 65) | |||
(N = 452) | (N = 256) | (N = 196) | ||
Basic and glycemia data | ||||
Age (years) | 71.4 ± 14.7 | 71.7 ± 15.3 | 71.2 ± 13.9 | 0.72 |
Male % | 346 (76.7%) | 206 (80.8%) | 140 (71.4%) | 0.03 |
BMI (kg) | 23.7 ± 8.8 | 24 ± 11 | 23.3 ± 4.5 | 0.36 |
HbA1c (%) | 6.3 ± 1.4 | 5.9 ± 0.9 | 6.7 ± 1.8 | < 0.01 |
Day 1 glucose metrics | ||||
Mean glucose (mg/dL) | 164.1 ± 41.7 | 148.7 ± 31.0 | 184.2 ± 45.1 | < 0.01 |
Peak glucose (mg/Dl) | 239.9 ± 81.6 | 194.7 ± 50.3 | 298.9 ± 76.9 | < 0.01 |
Hypoglycemia (< 40 mg/dL) | 2 (0.4%) | 0 (0%) | 2 (1.0%) | 0.18 |
Glycemic variation | ||||
MAGE | 67 ± 51.1 | 33.7 ± 18.6 | 110.5 ± 47.2 | < 0.01 |
CoV | 23.5 ± 11.2 | 17.2 ± 7.1 | 31.8 ± 10.1 | < 0.01 |
Comorbidities | ||||
Diabetes mellitus | 158 (35%) | 60 (23.4%) | 98 (50.0%) | < 0.01 |
Congestive heart failure | 143 (31.6%) | 74 (28.9%) | 69 (35.2%) | 0.19 |
Cerebrovascular disease | 50 (11.1%) | 27 (10.5%) | 23 (11.7%) | 0.80 |
Chronic airway disease | 127 (28.1%) | 70 (27.3%) | 57 (29.1%) | 0.76 |
Chronic renal disease | 53 (11.7%) | 26 (10.2%) | 27 (13.8%) | 0.30 |
Malignancy | 108 (23.9%) | 64 (25.0%) | 44 22.4(%) | 0.60 |
Severity-associated variables | ||||
APACHE II score | 27.4 ± 6.6 | 27.3 ± 6.6 | 27.5 ± 6.6 | 0.70 |
Lactate level, 0 h (mg/dl) | 26.5 ± 23.6 | 24.5 ± 20.1 | 29.1 ± 27.4 | 0.05 |
Lactate level, 24 h (mg/dl) | 21.7 ± 19.6 | 19.9 ± 15.9 | 24.2 ± 23.6 | 0.10 |
ScvO2, 0 h (%) | 74.7 ± 11.4 | 74.4 ± 11.3 | 75.2 ± 11.7 | 0.45 |
ScvO2, 6 h (%) | 74.6 ± 10.5 | 74.8 ± 10.5 | 74.3 ± 10.4 | 0.61 |
Laboratory data | ||||
Albumin (mg/dL) | 2.8 ± 0.6 | 2.9 ± 0.6 | 2.8 ± 0.6 | 0.21 |
Hemoglobin (g/dL) | 10.2 ± 2.3 | 10.3 ± 2.3 | 10.1 ± 2.4 | 0.29 |
Creatinine (mg/dL) | 2.1 ± 2.2 | 1.9 ± 1.8 | 2.3 ± 2.6 | 0.07 |
C-reactive protein (mg/dL) | 13.8 ± 10.6 | 14 ± 10.2 | 13.7 ± 11.1 | 0.80 |
Procalcitonin (ng/mL) | 17.4 ± 34.9 | 17 ± 34.5 | 17.8 ± 35.5 | 0.82 |
Outcomes | ||||
30-day mortality | 140 (31%) | 68 (26.6%) | 72 (36.7%) | 0.03 |