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Table 1 Characteristics of the 452 patients with sepsis categorized by glycemia variability

From: Higher glycemic variability within the first day of ICU admission is associated with increased 30-day mortality in ICU patients with sepsis

 

All

Low GV

High CV

p value

(MAGE  65)

(MAGE > 65)

(N = 452)

(N = 256)

(N = 196)

Basic and glycemia data

 Age (years)

71.4 ± 14.7

71.7 ± 15.3

71.2 ± 13.9

0.72

 Male  %

346 (76.7%)

206 (80.8%)

140 (71.4%)

0.03

 BMI (kg)

23.7 ± 8.8

24 ± 11

23.3 ± 4.5

0.36

 HbA1c (%)

6.3 ± 1.4

5.9 ± 0.9

6.7 ± 1.8

< 0.01

Day 1 glucose metrics

 Mean glucose (mg/dL)

164.1 ± 41.7

148.7 ± 31.0

184.2 ± 45.1

< 0.01

 Peak glucose (mg/Dl)

239.9 ± 81.6

194.7 ± 50.3

298.9 ± 76.9

< 0.01

 Hypoglycemia (< 40 mg/dL)

2 (0.4%)

0 (0%)

2 (1.0%)

0.18

Glycemic variation

 MAGE

67 ± 51.1

33.7 ± 18.6

110.5 ± 47.2

< 0.01

 CoV

23.5 ± 11.2

17.2 ± 7.1

31.8 ± 10.1

< 0.01

Comorbidities

 Diabetes mellitus

158 (35%)

60 (23.4%)

98 (50.0%)

< 0.01

 Congestive heart failure

143 (31.6%)

74 (28.9%)

69 (35.2%)

0.19

 Cerebrovascular disease

50 (11.1%)

27 (10.5%)

23 (11.7%)

0.80

 Chronic airway disease

127 (28.1%)

70 (27.3%)

57 (29.1%)

0.76

 Chronic renal disease

53 (11.7%)

26 (10.2%)

27 (13.8%)

0.30

 Malignancy

108 (23.9%)

64 (25.0%)

44 22.4(%)

0.60

Severity-associated variables

 APACHE II score

27.4 ± 6.6

27.3 ± 6.6

27.5 ± 6.6

0.70

 Lactate level, 0 h (mg/dl)

26.5 ± 23.6

24.5 ± 20.1

29.1 ± 27.4

0.05

 Lactate level, 24 h (mg/dl)

21.7 ± 19.6

19.9 ± 15.9

24.2 ± 23.6

0.10

 ScvO2, 0 h (%)

74.7 ± 11.4

74.4 ± 11.3

75.2 ± 11.7

0.45

 ScvO2, 6 h (%)

74.6 ± 10.5

74.8 ± 10.5

74.3 ± 10.4

0.61

Laboratory data

 Albumin (mg/dL)

2.8 ± 0.6

2.9 ± 0.6

2.8 ± 0.6

0.21

 Hemoglobin (g/dL)

10.2 ± 2.3

10.3 ± 2.3

10.1 ± 2.4

0.29

 Creatinine (mg/dL)

2.1 ± 2.2

1.9 ± 1.8

2.3 ± 2.6

0.07

 C-reactive protein (mg/dL)

13.8 ± 10.6

14 ± 10.2

13.7 ± 11.1

0.80

 Procalcitonin (ng/mL)

17.4 ± 34.9

17 ± 34.5

17.8 ± 35.5

0.82

Outcomes

 30-day mortality

140 (31%)

68 (26.6%)

72 (36.7%)

0.03

  1. Data are presented as mean ± SD and N (%)
  2. GV glycemic variability, MAGE mean amplitude of glycemic excursions, CoV coefficient of variation, DM diabetes mellitus, BMI body-mass index, HbA1c hemoglobin A1c, APACHE II acute physiology and chronic health evaluation II, ScvO2 central venous oxygen saturation