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Table 1 Characteristics of the 452 patients with sepsis categorized by glycemia variability

From: Higher glycemic variability within the first day of ICU admission is associated with increased 30-day mortality in ICU patients with sepsis

 AllLow GVHigh CVp value
(MAGE  65)(MAGE > 65)
(N = 452)(N = 256)(N = 196)
Basic and glycemia data
 Age (years)71.4 ± 14.771.7 ± 15.371.2 ± 13.90.72
 Male  %346 (76.7%)206 (80.8%)140 (71.4%)0.03
 BMI (kg)23.7 ± 8.824 ± 1123.3 ± 4.50.36
 HbA1c (%)6.3 ± 1.45.9 ± 0.96.7 ± 1.8< 0.01
Day 1 glucose metrics
 Mean glucose (mg/dL)164.1 ± 41.7148.7 ± 31.0184.2 ± 45.1< 0.01
 Peak glucose (mg/Dl)239.9 ± 81.6194.7 ± 50.3298.9 ± 76.9< 0.01
 Hypoglycemia (< 40 mg/dL)2 (0.4%)0 (0%)2 (1.0%)0.18
Glycemic variation
 MAGE67 ± 51.133.7 ± 18.6110.5 ± 47.2< 0.01
 CoV23.5 ± 11.217.2 ± 7.131.8 ± 10.1< 0.01
Comorbidities
 Diabetes mellitus158 (35%)60 (23.4%)98 (50.0%)< 0.01
 Congestive heart failure143 (31.6%)74 (28.9%)69 (35.2%)0.19
 Cerebrovascular disease50 (11.1%)27 (10.5%)23 (11.7%)0.80
 Chronic airway disease127 (28.1%)70 (27.3%)57 (29.1%)0.76
 Chronic renal disease53 (11.7%)26 (10.2%)27 (13.8%)0.30
 Malignancy108 (23.9%)64 (25.0%)44 22.4(%)0.60
Severity-associated variables
 APACHE II score27.4 ± 6.627.3 ± 6.627.5 ± 6.60.70
 Lactate level, 0 h (mg/dl)26.5 ± 23.624.5 ± 20.129.1 ± 27.40.05
 Lactate level, 24 h (mg/dl)21.7 ± 19.619.9 ± 15.924.2 ± 23.60.10
 ScvO2, 0 h (%)74.7 ± 11.474.4 ± 11.375.2 ± 11.70.45
 ScvO2, 6 h (%)74.6 ± 10.574.8 ± 10.574.3 ± 10.40.61
Laboratory data
 Albumin (mg/dL)2.8 ± 0.62.9 ± 0.62.8 ± 0.60.21
 Hemoglobin (g/dL)10.2 ± 2.310.3 ± 2.310.1 ± 2.40.29
 Creatinine (mg/dL)2.1 ± 2.21.9 ± 1.82.3 ± 2.60.07
 C-reactive protein (mg/dL)13.8 ± 10.614 ± 10.213.7 ± 11.10.80
 Procalcitonin (ng/mL)17.4 ± 34.917 ± 34.517.8 ± 35.50.82
Outcomes
 30-day mortality140 (31%)68 (26.6%)72 (36.7%)0.03
  1. Data are presented as mean ± SD and N (%)
  2. GV glycemic variability, MAGE mean amplitude of glycemic excursions, CoV coefficient of variation, DM diabetes mellitus, BMI body-mass index, HbA1c hemoglobin A1c, APACHE II acute physiology and chronic health evaluation II, ScvO2 central venous oxygen saturation