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Table 2 Cox proportional hazard regression analysis for 30-day mortality

From: Higher glycemic variability within the first day of ICU admission is associated with increased 30-day mortality in ICU patients with sepsis

CharacteristicsUnivariateMultivariate
HR (95% CI)p valueHR (95% CI)p value
Age, per 1 year increment1.003 (0.991–1.014)0.631.005 (0.993–1.018)0.41
Sex
 Female1 [Reference] 1 [Reference] 
 Male1.113 (0.743–1.667)0.601.292 (0.822–2.031)0.27
HbA1c, per 1 increment1.045 (0.935–1.167)0.440.919 (0.803–1.051)0.92
Cerebrovascular disease
 No1 [Reference] 1 [Reference] 
 Yes0.602 (0.317–1.146)0.120.502 (0.255–0.986)0.05
Chronic pulmonary disease
 No1 [Reference] 1 [Reference] 
 Yes0.506 (0.328–0.779)< 0.010.483 (0.305–0.764)< 0.01
APACHE II, per 1 increment1.056 (1.027–1.086)< 0.011.045 (1.013–1.078)< 0.01
Lactate 0-h, per 1 mg/dL increment1.010 (1.005–1.014)< 0.011.009 (1.003–1.014)< 0.01
Hemoglobin, per 1 g/dL increment0.967 (0.818–2.672)0.401.002 (09.25–1.085)0.97
Creatinine, per 1 mg/dL increment1.048 (0.993–1.105)0.091.031 (0.954–1.115)0.44
Hypoglycemia episode (< 40 mg/dL)
 No1 [Reference] 1 [Reference] 
 Yes2.098 (0.293–15.009)0.461.947 (0.245–15.47)0.53
Mean day 1 glucose, per 1 mg/dL increment1.004 (1.000–1.008)0.041.008 (1.000–1.016)0.04
Peak day 1 glucose, per 1 mg/dL increment1.002 (1.000–1.004)0.080.997 (0.992–1.001)0.18
MAGE, cut-off point 65 mg/dL
 Low1 [Reference] 1 [Reference] 
 High1.488 (1.068–2.072)0.021.607 (1.008–2.563)0.04
  1. HR hazard ratio, CI confidence interval, HbA1c hemoglobin A1c, APACHE II acute physiology and chronic health evaluation II, MAGE mean amplitude of glycemic excursions