Skip to main content

Table 2 Cox proportional hazard regression analysis for 30-day mortality

From: Higher glycemic variability within the first day of ICU admission is associated with increased 30-day mortality in ICU patients with sepsis

Characteristics

Univariate

Multivariate

HR (95% CI)

p value

HR (95% CI)

p value

Age, per 1 year increment

1.003 (0.991–1.014)

0.63

1.005 (0.993–1.018)

0.41

Sex

 Female

1 [Reference]

 

1 [Reference]

 

 Male

1.113 (0.743–1.667)

0.60

1.292 (0.822–2.031)

0.27

HbA1c, per 1 increment

1.045 (0.935–1.167)

0.44

0.919 (0.803–1.051)

0.92

Cerebrovascular disease

 No

1 [Reference]

 

1 [Reference]

 

 Yes

0.602 (0.317–1.146)

0.12

0.502 (0.255–0.986)

0.05

Chronic pulmonary disease

 No

1 [Reference]

 

1 [Reference]

 

 Yes

0.506 (0.328–0.779)

< 0.01

0.483 (0.305–0.764)

< 0.01

APACHE II, per 1 increment

1.056 (1.027–1.086)

< 0.01

1.045 (1.013–1.078)

< 0.01

Lactate 0-h, per 1 mg/dL increment

1.010 (1.005–1.014)

< 0.01

1.009 (1.003–1.014)

< 0.01

Hemoglobin, per 1 g/dL increment

0.967 (0.818–2.672)

0.40

1.002 (09.25–1.085)

0.97

Creatinine, per 1 mg/dL increment

1.048 (0.993–1.105)

0.09

1.031 (0.954–1.115)

0.44

Hypoglycemia episode (< 40 mg/dL)

 No

1 [Reference]

 

1 [Reference]

 

 Yes

2.098 (0.293–15.009)

0.46

1.947 (0.245–15.47)

0.53

Mean day 1 glucose, per 1 mg/dL increment

1.004 (1.000–1.008)

0.04

1.008 (1.000–1.016)

0.04

Peak day 1 glucose, per 1 mg/dL increment

1.002 (1.000–1.004)

0.08

0.997 (0.992–1.001)

0.18

MAGE, cut-off point 65 mg/dL

 Low

1 [Reference]

 

1 [Reference]

 

 High

1.488 (1.068–2.072)

0.02

1.607 (1.008–2.563)

0.04

  1. HR hazard ratio, CI confidence interval, HbA1c hemoglobin A1c, APACHE II acute physiology and chronic health evaluation II, MAGE mean amplitude of glycemic excursions