Parameters | ARDS cohort (n = 48) | D28 ARDS survivors (n = 36) | D28 ARDS non-survivors (n = 12) | Comparison survivors vs non-survivors |
---|---|---|---|---|
Sex (M, %) | 27 (56%) | 22 (61.1%) | 5 (41.7%) | 0.24 (Chi2) |
Age (years) | 61 ± 17 | 58 ± 17 | 68 ± 14 | 0.25 |
SOFA | 8 [7;11] | 8 [7;11] | 10 [8;14] | 0.09 (MW) |
SAPS II | 57 ± 15 | 56 ± 16 | 60 ± 14 | 0.49 |
Weight (kg) | 75.7 ± 20.3 | 79.5 ± 21.2 | 64.4 ± 12.1 | 0.02 |
Circulatory parameters | ||||
SAP/MAP/DAP mmHg | 114 ± 19/77 ± 10/57 ± 9 | 114 ± 16/78 ± 10/59 ± 9 | 114 ± 28/72 ± 11/51 ± 8 | 0.99/0.10/0.01 |
Heart rate bpm | 95 ± 22 | 95 ± 23 | 95 ± 19 | 0.97 |
Sinus rhythm | 42 (87.5%) | 31 (86.1%) | 11 (91.7%) | 0.61 (Chi2) |
Ventilator settings | ||||
Tidal volume, ml/kg of IBW | 6.9 ± 1.1 | 6.9 ± 1.2 | 6.8 ± 0.8 | 0.74 |
PEEP cmH2O | 10.6 ± 2.9 | 9.8 ± 2.6 | 10.2 ± 2.9 | 0.65 |
Autopeep cmH2O | 0.8 ± 1.2 | 0.9 ± 1.3 | 0.5 ± 0.7 | 0.31 |
Plateau pressure cmH2O | 23.2 ± 4.4 | 22.6 ± 4.3 | 24.3 ± 4.5 | 0.25 |
Driving pressurecmH2O | 12.4 ± 4.1 | 11.8 ± 4.1 | 13.7 ± 3.9 | 0.19 |
Respiratory rate/min | 24.0 ± 3.5 | 23.3 ± 3.4 | 25.5 ± 3.8 | 0.01 |
Arterial blood gases | ||||
FiO2 (%) | 70 ± 21 | 67 ± 19 | 79 ± 25 | 0.10 |
pH | 7.31 ± 0.14 | 7.34 ± 0.13 | 7.23 ± 0.16 | 0.01 |
pCO2 mmHg | 45.6 ± 11.1 | 45.6 ± 12.1 | 45.7 ± 7.4 | 0.96 |
pO2 mmHg | 83.6 ± 32.8 | 81.1 ± 24.1 | 91.3 ± 51.7 | 0.36 |
HCO3-mmol | 22.1 ± 6.1 | 23.1 ± 5.9 | 19.1 ± 5.8 | 0.05 |
SaO2% | 93.5 ± 5.0 | 94.0 ± 2.8 | 91.9 ± 8.9 | 0.20 |
Lactate mmol | 2.1 ± 2.4 | 1.4 ± 0.9 | 3.9 ± 4.0 | 0.002 |
PaO2:FiO2 ratio | 126 ± 48 | 127 ± 46 | 123 ± 55 | 0.77 |
Treatments in ICU | ||||
Vasopressor support | 32 (66.7%) | 21 (58.3%) | 11 (91.7%) | 0.03 (Chi2) |
Inotropic support | 6 (12.5%) | 2 (5.6%) | 4 (33.3%) | 0.01 (Chi2) |
Neuromuscular blockade > 24 h | 30 (62.5%) | 25 (69.4%) | 9 (75%) | 0.71 (Chi2) |
Prone positioning | 18 (37.5%) | 15 (41.7%) | 3 (25%) | 0.30 (Chi2) |
Inhaled NO | 6 (12.5%) | 3 (8.3%) | 3 (25%) | 0.13 (Chi2) |
VV ECMO | 2 (4.2%) | 1 (2.8%) | 1 (8.3%) | 0.10 (Chi2) |
Renal replacement therapy | 12 (25%) | 9 (25%) | 3 (25%) | 1.00 (Chi2) |
Outcome | ||||
Mortality D28 n (%) | 12 (25%) | – | – | |
Mortality D90 n (%) | 14 (29.2%) | – | – | |
D28 ventilator-free days | 20.0 [1.3; 23.0] | 20.5 [14.3; 23.8] | 0 [0; 5.25] | 0.003 (MW) |