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Annals of Intensive Care
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Table 2 Univariate and multivariable analyses of factors associated with hospital mortality in patients with influenza-associated ARDS

From: Impact of corticosteroid treatment on clinical outcomes of influenza-associated ARDS: a nationwide multicenter study

VariablesUnivariate analysisaMultivariable analysis†
OR (95% CI)p valueAdjusted OR (95% CI)p value
APACHE II score1.11 (1.07–1.16)< 0.0011.12 (1.07–1.17) < 0.001
PaO2/FiO2 ratio0.99 (0.99–1.00)0.007  
WBC1.00 (1.00–1.00)0.015  
Albumin, g/dL0.55 (0.31–0.97)0.039  
Malignancy2.80 (1.27–6.18)0.0112.71 (1.06–6.90)0.037
Influenza type A0.50 (0.27–0.93)0.0280.38 (0.18–0.82)0.013
ECMO4.53 (2.25–9.14)< 0.0018.51 (3.52–20.55) < 0.001
Vasopressor infusion2.89 (1.59–5.25)0.001  
Hemodialysis2.54 (1.26–5.12)0.009  
Early CS treatment3.24 (1.80–5.81)< 0.0015.02 (2.39–10.54) < 0.001
  1. APACHE II Acute Physiology and Chronic Health Evaluation II, ARDS acute respiratory distress syndrome, BMI body mass index, CI confidence interval, CS corticosteroid, ECMO extracorporeal membrane oxygenation, FiO2 fraction of inspired oxygen, PaO2 partial pressure of arterial oxygen, OR odds ratio, WBC white blood cell
  2. aThe variable representing early CS treatment, basic demographic variables, and all clinical variables possibly associated with hospital mortality were analyzed in univariate logistic regression models
  3. †We replaced missing values (APACHE II score in 4 patients, WBC count in 2 patients, and albumin in 40 patients) by the corresponding overall median values for the multivariable regression analysis. Variables associated with hospital mortality with a p value < 0.05 in univariate models were selected into the multivariable logistic regression model, using a stepwise algorithm with criteria of p > 0.05 for eliminating variables
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