Variables | Patients who need intubation (n = 115) | Patients who were not intubated (n = 187) | p |
---|---|---|---|
Age (year) median, (IQR) | 63 (53–69) | 63 (56–71) | 0.25 |
Gender, male (n, %) | 81 (70) | 127 (68) | 0.74 |
Comorbidities (n, %) | |||
Cardiovascular | 59 (58) | 92 (56) | 0.85 |
Pulmonary | 41 (40.6) | 63 (38.7) | 0.85 |
Kidney | 15 (15) | 34 (21) | 0.31 |
Charlson Index median, (IQR) missing data = 36 | 4 (3–6) | 5 (4–7) | 0.006 |
Underlying disease (n, %) | |||
Haematological malignancy, n (%) | 90 (78) | 135 (72) | 0.12 |
Allogeneic stem cell transplant, n (%) | 15 (14.7) | 13 (9.3) | 0.27 |
Performance status < 2 (n, %) | 68 (59) | 111 (59) | 0.99 |
Number of quadrant involved = 3 or 4 (n, %) missing data = 56 | 56/96 (44) | 66/150 (31) | 0.04 |
Aetiology of ARF (n, %) | 0.07 | ||
Bacterial or viral pneumonia | 58 (50) | 92 (49.5) | |
Opportunistic infection | 27 (23.5) | 27 (14.4) | |
Lung involvement by the underlying disease drug-related pulmonary toxicity | 7 (6) | 19 (10) | |
Other identified causes | 13 (11) | 39 (21) | |
No identified cause | 9 (7.8) | 8 (4.3) | |
Neutropenia recovery at admission (n, %) | 15 (13) | 13 (7) | 0.12 |
SOFA day 1 missing data = 25 | 6 [3–9] | 4 [2–6] | < 0.001 |
RR 30 min after randomization median, (IQR) missing data = 14 | 29 (22.5–35) | 26 (22–32) | 0.02 |
Oxygen flow > 9 L/min at randomization, n (%) | 66 (57.4) | 100 (53.5) | 0.02 |
ROX index at H6 | 4.79 [3.69–7.01] | 6.10 [4.48–8.68] | < 0.001 |
NIV group | 20 (17.4) | 25 (13.3) | 0.43 |
Glasgow score at 15 at Day 1 (n,%) | 97 (84) | 160 (86) | 0.86 |
Length between ICU admission and intubation | 2 (1–3) | NA | NA |
Outcomes | |||
Vasopressor during ICU stay, n (%) | 99 (86) | 34 (18) | < 0.001 |
Renal replacement therapy during ICU stay, n (%) | 38 (33) | 11 (6) | < 0.001 |
End of life decision during ICU stay, n (%) | 31 (29) | 10 (5.4) | < 0.001 |
ICU mortality (n,%) | 64 (55.7) | 19 (10.2) | < 0.001 |
Length of ICU stay for survival patient (n = 219) | 17 (12.5–27) | 7 (5–11) | < 0.001 |
Length of hospital stay median, (IQR) (n = 302) | 32 (15–60) | 21 (13–32) | 0.001 |