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Table 1 Characteristics and outcomes based on the need for intubation

From: Performance of the ROX index to predict intubation in immunocompromised patients receiving high-flow nasal cannula for acute respiratory failure

Variables Patients who need intubation (n = 115) Patients who were not intubated (n = 187) p
Age (year) median, (IQR) 63 (53–69) 63 (56–71) 0.25
Gender, male (n, %) 81 (70) 127 (68) 0.74
Comorbidities (n, %)
 Cardiovascular 59 (58) 92 (56) 0.85
 Pulmonary 41 (40.6) 63 (38.7) 0.85
 Kidney 15 (15) 34 (21) 0.31
Charlson Index median, (IQR) missing data = 36 4 (3–6) 5 (4–7) 0.006
Underlying disease (n, %)
 Haematological malignancy, n (%) 90 (78) 135 (72) 0.12
Allogeneic stem cell transplant, n (%) 15 (14.7) 13 (9.3) 0.27
Performance status < 2 (n, %) 68 (59) 111 (59) 0.99
Number of quadrant involved = 3 or 4 (n, %) missing data = 56 56/96 (44) 66/150 (31) 0.04
Aetiology of ARF (n, %)    0.07
 Bacterial or viral pneumonia 58 (50) 92 (49.5)  
 Opportunistic infection 27 (23.5) 27 (14.4)  
 Lung involvement by the underlying disease drug-related pulmonary toxicity 7 (6) 19 (10)  
 Other identified causes 13 (11) 39 (21)  
 No identified cause 9 (7.8) 8 (4.3)  
Neutropenia recovery at admission (n, %) 15 (13) 13 (7) 0.12
SOFA day 1 missing data = 25 6 [3–9] 4 [2–6]  < 0.001
RR 30 min after randomization median, (IQR) missing data = 14 29 (22.5–35) 26 (22–32) 0.02
Oxygen flow > 9 L/min at randomization, n (%) 66 (57.4) 100 (53.5) 0.02
ROX index at H6 4.79 [3.69–7.01] 6.10 [4.48–8.68]  < 0.001
NIV group 20 (17.4) 25 (13.3) 0.43
Glasgow score at 15 at Day 1 (n,%) 97 (84) 160 (86) 0.86
Length between ICU admission and intubation 2 (1–3) NA NA
Outcomes
 Vasopressor during ICU stay, n (%) 99 (86) 34 (18)  < 0.001
 Renal replacement therapy during ICU stay, n (%) 38 (33) 11 (6)  < 0.001
 End of life decision during ICU stay, n (%) 31 (29) 10 (5.4)  < 0.001
 ICU mortality (n,%) 64 (55.7) 19 (10.2)  < 0.001
Length of ICU stay for survival patient (n = 219) 17 (12.5–27) 7 (5–11)  < 0.001
Length of hospital stay median, (IQR) (n = 302) 32 (15–60) 21 (13–32) 0.001
  1. ARF: acute respiratory failure, NIV: non-invasive ventilation, RR: respiratory rate