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Table 2 Characteristics and outcomes based on ROX index over or under 4.88

From: Performance of the ROX index to predict intubation in immunocompromised patients receiving high-flow nasal cannula for acute respiratory failure

Variables Patients with ROX index H6 > 4.88 (n = 184) Patients with ROX index H6 ≤ 4.88 (n = 118) p
Age (year) median, (IQR) 63.5 (55–71) 63 (54–69) 0.57
Gender, male (n, %) 130 (71) 78 (66) 0.48
Comorbidities (n, %)
 Cardiovascular 93 (58) 58 (56) 0.8
 Pulmonary 61 (38) 43 (41) 0.69
 Renal 28 (18) 21 (20) 0.72
Charlson Index median, (IQR) missing data = 36 5 (4–7) 5 (3–6) 0.42
Underlying disease (n, %)
 Haematological malignancy, n (%) 139 (75) 86 (73) 0.36
Allogeneic stem cell transplant, n (%) 19 (11) 9 (8) 0.56
Performance status > 2 (n, %) 63 (34) 42 (36) 0.13
Number of quadrant involved = 3 or 4 (n,%) missing data = 56 68 (45) 54 (57) 0.09
Aetiology of ARF (n, %)    0.84
 Bacterial or viral pneumonia 92 (50) 58 (49)  
 Opportunistic infection 29 (16) 25 (21)  
 Lung involvement by the underlying disease Drug-related pulmonary toxicity 16 (9) 10 (8)  
 Other identified causes 33 (18) 19 (16)  
 No identified cause 12 (6) 5 (4)  
Neutropenia recovery at admission (n,%) 18 (10) 7 (6) 0.33
SOFA day 1 missing data = 25 4 (2–7) 4.5 (2–7) 0.94
RR 30 min after randomization median, (IQR) missing data = 14 25 (21–30) 31 (25–35)  < 0.001
Oxygen flow > 9 L/min at randomization, n (%) 94 (51) 72 (13) 0.49
NIV group 30 (16) 15 (13) 0.45
Glasgow score at 15 at Day 1 (n, %) 160 (87) 97 (82) 0.52
Outcomes
 Intubated during ICU (n, %) 55 (30) 60 (51)  < 0.001
 Length between ICU admission and intubation 3 (1–4.5) 2 (1–2.5) 0.005
 Vasopressor during ICU stay, n (%) 71 (39) 62 (52) 0.03
Renal Replacement Therapy during ICU stay, n (%) 30 (16) 19 (16) 0.32
 End of life decision during ICU stay, n (%) 47 (26) 47 (36) 0.02
 Day 28 mortality (n,%) 39 (21) 44 (37) 0.003
Length of ICU stay, median (IQR) survival patient (n = 219) 8 (5–13) 10 (6–17.7) 0.02
Length of hospital stay median, (IQR) (n = 302 24 (15–38) 22 (12–40) 0.52